Distribution and genetic diversity of multi-drug-resistant Klebsiella pneumoniae at the human–animal–environment interface in Pakistan
Klebsiella pneumoniae is ubiquitous and known to be a notorious pathogen of humans, animals, and plant-based foods. K. pneumoniae is a recognized trafficker of antibiotic resistance genes (ARGs) between and from different ecological niches. A total of 775 samples ( n = 775) were collected from Septe...
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| Published in | Frontiers in microbiology Vol. 13; p. 898248 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Frontiers Media S.A
06.09.2022
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| Abstract | Klebsiella pneumoniae is ubiquitous and known to be a notorious pathogen of humans, animals, and plant-based foods.
K. pneumoniae
is a recognized trafficker of antibiotic resistance genes (ARGs) between and from different ecological niches. A total of 775 samples (
n
= 775) were collected from September 2017 to August 2019 from humans, animals, and environmental sources by applying the random convenient sampling technique. A total of 120 (15.7%) samples were confirmed as
K. pneumoniae
. The distribution of
K. pneumoniae
among humans, the environment, and animals was 17.1, 12.38, and 10%, respectively. Isolates have shown significant resistance against all the subjected antibiotics agents except colistin. ARGs profiling revealed that the highest percentage prevalence (67.5%) of
bla
CTX
–
M
was estimated in the isolates, and various carbapenem resistance genes that were found in the study were
bla
NDM
–1
(43.3%),
bla
OXA
–48
(38%), and (1.67%)
bla
KPC
–2
. Overall, 21 distinct sequence types (ST) and 13 clonal complexes (CCs) were found through the multi-locus sequence typing (MLST) analysis. Taking together, the distribution of multi-drug resistance (MDR)
K. pneumoniae
clones in the community and associated environment is alarming for the health care system of the country. Health policymakers should consider the role of all the integral parts of humans, animals, and the associated environment intently to cope with this serious public and animal health concern. |
|---|---|
| AbstractList | Klebsiella pneumoniae is ubiquitous and known to be a notorious pathogen of humans, animals, and plant-based foods.
K. pneumoniae
is a recognized trafficker of antibiotic resistance genes (ARGs) between and from different ecological niches. A total of 775 samples (
n
= 775) were collected from September 2017 to August 2019 from humans, animals, and environmental sources by applying the random convenient sampling technique. A total of 120 (15.7%) samples were confirmed as
K. pneumoniae
. The distribution of
K. pneumoniae
among humans, the environment, and animals was 17.1, 12.38, and 10%, respectively. Isolates have shown significant resistance against all the subjected antibiotics agents except colistin. ARGs profiling revealed that the highest percentage prevalence (67.5%) of
bla
CTX
–
M
was estimated in the isolates, and various carbapenem resistance genes that were found in the study were
bla
NDM
–1
(43.3%),
bla
OXA
–48
(38%), and (1.67%)
bla
KPC
–2
. Overall, 21 distinct sequence types (ST) and 13 clonal complexes (CCs) were found through the multi-locus sequence typing (MLST) analysis. Taking together, the distribution of multi-drug resistance (MDR)
K. pneumoniae
clones in the community and associated environment is alarming for the health care system of the country. Health policymakers should consider the role of all the integral parts of humans, animals, and the associated environment intently to cope with this serious public and animal health concern. Klebsiella pneumoniae is ubiquitous and known to be a notorious pathogen of humans, animals, and plant-based foods. K. pneumoniae is a recognized trafficker of antibiotic resistance genes (ARGs) between and from different ecological niches. A total of 775 samples (n = 775) were collected from September 2017 to August 2019 from humans, animals, and environmental sources by applying the random convenient sampling technique. A total of 120 (15.7%) samples were confirmed as K. pneumoniae. The distribution of K. pneumoniae among humans, the environment, and animals was 17.1, 12.38, and 10%, respectively. Isolates have shown significant resistance against all the subjected antibiotics agents except colistin. ARGs profiling revealed that the highest percentage prevalence (67.5%) of blaCTX–M was estimated in the isolates, and various carbapenem resistance genes that were found in the study were blaNDM–1 (43.3%), blaOXA–48 (38%), and (1.67%) blaKPC–2. Overall, 21 distinct sequence types (ST) and 13 clonal complexes (CCs) were found through the multi-locus sequence typing (MLST) analysis. Taking together, the distribution of multi-drug resistance (MDR) K. pneumoniae clones in the community and associated environment is alarming for the health care system of the country. Health policymakers should consider the role of all the integral parts of humans, animals, and the associated environment intently to cope with this serious public and animal health concern. |
| Author | Chaudhry, Tamoor Hamid Amir, Afreenish Siddique, Abu Baker Khurshid, Mohsin Yasmeen, Nafeesa Salman, Muhammad Muzammil, Saima Aslam, Bilal Arshad, Muhammad Imran Baloch, Zulqarnain Rasool, Muhammad Hidayat Xia, Xueshan |
| AuthorAffiliation | 4 National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University , Guangzhou , China 3 Institute of Microbiology, University of Agriculture Faisalabad , Faisalabad , Pakistan 2 National Institute of Health , Islamabad , Pakistan 5 Faculty of Life Science and Technology, Kunming University of Science and Technology , Kunming , China 1 Department of Microbiology, Government College University Faisalabad , Faisalabad , Pakistan |
| AuthorAffiliation_xml | – name: 4 National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University , Guangzhou , China – name: 5 Faculty of Life Science and Technology, Kunming University of Science and Technology , Kunming , China – name: 1 Department of Microbiology, Government College University Faisalabad , Faisalabad , Pakistan – name: 3 Institute of Microbiology, University of Agriculture Faisalabad , Faisalabad , Pakistan – name: 2 National Institute of Health , Islamabad , Pakistan |
| Author_xml | – sequence: 1 givenname: Bilal surname: Aslam fullname: Aslam, Bilal – sequence: 2 givenname: Tamoor Hamid surname: Chaudhry fullname: Chaudhry, Tamoor Hamid – sequence: 3 givenname: Muhammad Imran surname: Arshad fullname: Arshad, Muhammad Imran – sequence: 4 givenname: Saima surname: Muzammil fullname: Muzammil, Saima – sequence: 5 givenname: Abu Baker surname: Siddique fullname: Siddique, Abu Baker – sequence: 6 givenname: Nafeesa surname: Yasmeen fullname: Yasmeen, Nafeesa – sequence: 7 givenname: Mohsin surname: Khurshid fullname: Khurshid, Mohsin – sequence: 8 givenname: Afreenish surname: Amir fullname: Amir, Afreenish – sequence: 9 givenname: Muhammad surname: Salman fullname: Salman, Muhammad – sequence: 10 givenname: Muhammad Hidayat surname: Rasool fullname: Rasool, Muhammad Hidayat – sequence: 11 givenname: Xueshan surname: Xia fullname: Xia, Xueshan – sequence: 12 givenname: Zulqarnain surname: Baloch fullname: Baloch, Zulqarnain |
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| CitedBy_id | crossref_primary_10_1093_jacamr_dlad076 crossref_primary_10_3390_antibiotics12030525 crossref_primary_10_1016_j_scitotenv_2023_168453 crossref_primary_10_3390_antibiotics12050812 crossref_primary_10_1016_j_heliyon_2024_e28052 crossref_primary_10_3390_antibiotics12030539 |
| Cites_doi | 10.1089/mdr.2019.0420 10.1016/j.tim.2014.09.003 10.3389/fmicb.2020.612020 10.1002/ijc.29973 10.1186/s13073-019-0706-y 10.5005/jp-journals-10071-23118 10.1016/j.rvsc.2013.10.009 10.3855/jidc.674 10.1098/rstb.2014.0083 10.1016/j.vetmic.2016.08.010 10.3389/fmicb.2017.02476 10.2217/fmb-2017-0119 10.1007/s40572-016-0089-9 10.29261/pakvetj/2019.037 10.1089/fpd.2014.1895 10.1128/JCM.43.8.4178-4182.2005 10.14202/IJOH.2016.69-74 10.1016/j.meegid.2014.11.003 10.1371/journal.pone.0062712 10.1016/S1473-3099(13)70190-7 10.1016/j.tim.2016.09.007 10.1093/cid/cit070 10.3855/jidc.599 10.1371/journal.pone.0189438 10.5897/AJMR11.1457 10.12669/pjms.293.3576 10.2174/1874285801105010091 10.2147/IDR.S173867 10.1128/AAC.01019-15 10.1080/22221751.2020.1799721 10.1371/journal.pone.0221771 10.2147/IDR.S176759 10.2147/IDR.S248091 |
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| Copyright | Copyright © 2022 Aslam, Chaudhry, Arshad, Muzammil, Siddique, Yasmeen, Khurshid, Amir, Salman, Rasool, Xia and Baloch. 2022 Aslam, Chaudhry, Arshad, Muzammil, Siddique, Yasmeen, Khurshid, Amir, Salman, Rasool, Xia and Baloch |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Ziad Daoud, Central Michigan University, United States These authors have contributed equally to this work Reviewed by: Ruichao Li, Yangzhou University, China; Vijayalakshmi Selvakumar, Kangwon National University, South Korea This article was submitted to Antimicrobials, Resistance and Chemotherapy, a section of the journal Frontiers in Microbiology |
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| Snippet | Klebsiella pneumoniae is ubiquitous and known to be a notorious pathogen of humans, animals, and plant-based foods.
K. pneumoniae
is a recognized trafficker of... Klebsiella pneumoniae is ubiquitous and known to be a notorious pathogen of humans, animals, and plant-based foods. K. pneumoniae is a recognized trafficker of... |
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| StartPage | 898248 |
| SubjectTerms | antimicrobial resistance human-animal-environment Microbiology MLST analysis Pakistan transmission |
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| Title | Distribution and genetic diversity of multi-drug-resistant Klebsiella pneumoniae at the human–animal–environment interface in Pakistan |
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