Nonpathogenic Simian Immunodeficiency Virus Infection of Sooty Mangabeys Is Not Associated with High Levels of Autologous Neutralizing Antibodies

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Published inJournal of Virology Vol. 84; no. 12; pp. 6248 - 6253
Main Authors Li, Bing, Stefano-Cole, Kelly, Kuhrt, David M., Gordon, Shari N., Else, James G., Mulenga, Joseph, Allen, Susan, Sodora, Donald L., Silvestri, Guido, Derdeyn, Cynthia A.
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.06.2010
American Society for Microbiology (ASM)
Subjects
Animals
Antibodies, Neutralizing - immunology
Antibodies, Viral - immunology
Cercocebus atys - immunology
Cercocebus atys - virology
HIV Infections - immunology
HIV Infections - virology
HIV-1 - immunology
HIV-1 - pathogenicity
HIV-1 - physiology
Host-Pathogen Interactions
Human immunodeficiency virus 1
Humans
Pathogenesis and Immunity
Primates
Simian Acquired Immunodeficiency Syndrome - immunology
Simian Acquired Immunodeficiency Syndrome - virology
Simian immunodeficiency virus
Simian Immunodeficiency Virus - immunology
Simian Immunodeficiency Virus - pathogenicity
Simian Immunodeficiency Virus - physiology
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Abstract Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
AbstractList Simian immunodeficiency virus (SIV) infection of natural-host species, such as sooty mangabeys (SMs), is characterized by a high level of viral replication and a low level of generalized immune activation, despite evidence of an adaptive immune response. Here the ability of SIV-infected SMs to mount neutralizing antibodies (Nab) against autologous virus was compared to that of human immunodeficiency virus type 1 (HIV-1) subtype C-infected subjects. While high levels of Nab were observed in HIV-1 infection, samples obtained at comparable time points from SM exhibited relatively low titers of autologous Nab. Nevertheless, SM plasma with higher Nab titers also contained elevated peripheral CD4+ T-cell levels, suggesting a potential immunologic benefit for SMs. These data indicate that AIDS resistance in these primates is not due to high Nab titers and raise the possibility that low levels of Nab might be an inherent feature of natural-host SIV infections.
Simian immunodeficiency virus (SIV) infection of natural-host species, such as sooty mangabeys (SMs), is characterized by a high level of viral replication and a low level of generalized immune activation, despite evidence of an adaptive immune response. Here the ability of SIV-infected SMs to mount neutralizing antibodies (Nab) against autologous virus was compared to that of human immunodeficiency virus type 1 (HIV-1) subtype C-infected subjects. While high levels of Nab were observed in HIV-1 infection, samples obtained at comparable time points from SM exhibited relatively low titers of autologous Nab. Nevertheless, SM plasma with higher Nab titers also contained elevated peripheral CD4(+) T-cell levels, suggesting a potential immunologic benefit for SMs. These data indicate that AIDS resistance in these primates is not due to high Nab titers and raise the possibility that low levels of Nab might be an inherent feature of natural-host SIV infections.Simian immunodeficiency virus (SIV) infection of natural-host species, such as sooty mangabeys (SMs), is characterized by a high level of viral replication and a low level of generalized immune activation, despite evidence of an adaptive immune response. Here the ability of SIV-infected SMs to mount neutralizing antibodies (Nab) against autologous virus was compared to that of human immunodeficiency virus type 1 (HIV-1) subtype C-infected subjects. While high levels of Nab were observed in HIV-1 infection, samples obtained at comparable time points from SM exhibited relatively low titers of autologous Nab. Nevertheless, SM plasma with higher Nab titers also contained elevated peripheral CD4(+) T-cell levels, suggesting a potential immunologic benefit for SMs. These data indicate that AIDS resistance in these primates is not due to high Nab titers and raise the possibility that low levels of Nab might be an inherent feature of natural-host SIV infections.
Simian immunodeficiency virus (SIV) infection of natural-host species, such as sooty mangabeys (SMs), is characterized by a high level of viral replication and a low level of generalized immune activation, despite evidence of an adaptive immune response. Here the ability of SIV-infected SMs to mount neutralizing antibodies (Nab) against autologous virus was compared to that of human immunodeficiency virus type 1 (HIV-1) subtype C-infected subjects. While high levels of Nab were observed in HIV-1 infection, samples obtained at comparable time points from SM exhibited relatively low titers of autologous Nab. Nevertheless, SM plasma with higher Nab titers also contained elevated peripheral CD4 + T-cell levels, suggesting a potential immunologic benefit for SMs. These data indicate that AIDS resistance in these primates is not due to high Nab titers and raise the possibility that low levels of Nab might be an inherent feature of natural-host SIV infections.
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Author David M. Kuhrt
Shari N. Gordon
Joseph Mulenga
Bing Li
James G. Else
Guido Silvestri
Cynthia A. Derdeyn
Susan Allen
Donald L. Sodora
Kelly Stefano-Cole
AuthorAffiliation Department of Pathology and Laboratory Medicine, 1 Yerkes National Primate Research Center, 2 Department of Global Health, Emory University, Atlanta, Georgia, 3 Department of Medicine, Infectious Diseases Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, 4 Zambia Blood Transfusion Service, Lusaka, Zambia, 5 Seattle Biomedical Research Institute, Seattle, Washington, 6 Department of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania 7
AuthorAffiliation_xml – name: Department of Pathology and Laboratory Medicine, 1 Yerkes National Primate Research Center, 2 Department of Global Health, Emory University, Atlanta, Georgia, 3 Department of Medicine, Infectious Diseases Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, 4 Zambia Blood Transfusion Service, Lusaka, Zambia, 5 Seattle Biomedical Research Institute, Seattle, Washington, 6 Department of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania 7
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Simian immunodeficiency virus (SIV) infection of natural-host species, such as sooty mangabeys (SMs), is characterized by a high level of viral replication and...
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SubjectTerms Animals
Antibodies, Neutralizing - immunology
Antibodies, Viral - immunology
Cercocebus atys - immunology
Cercocebus atys - virology
HIV Infections - immunology
HIV Infections - virology
HIV-1 - immunology
HIV-1 - pathogenicity
HIV-1 - physiology
Host-Pathogen Interactions
Human immunodeficiency virus 1
Humans
Pathogenesis and Immunity
Primates
Simian Acquired Immunodeficiency Syndrome - immunology
Simian Acquired Immunodeficiency Syndrome - virology
Simian immunodeficiency virus
Simian Immunodeficiency Virus - immunology
Simian Immunodeficiency Virus - pathogenicity
Simian Immunodeficiency Virus - physiology
Title Nonpathogenic Simian Immunodeficiency Virus Infection of Sooty Mangabeys Is Not Associated with High Levels of Autologous Neutralizing Antibodies
URI http://jvi.asm.org/content/84/12/6248.abstract
https://www.ncbi.nlm.nih.gov/pubmed/20375163
https://www.proquest.com/docview/733335372
https://www.proquest.com/docview/746299912
https://pubmed.ncbi.nlm.nih.gov/PMC2876631
Volume 84
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