Construction and evaluation of fibrillar composite hydrogel of collagen/konjac glucomannan for potential biomedical applications
Konjac glucomannan (KGM) is recognized as a safe material for its health-promoting benefits and thus widely used in various fields including pharmaceutical industry. In recent decades, the combination of collagen and KGM attracts more attentions for biomedical purpose, especially the hybrid films of...
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Published in | Regenerative biomaterials Vol. 5; no. 4; pp. 239 - 250 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Oxford University Press
01.08.2018
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Abstract | Konjac glucomannan (KGM) is recognized as a safe material for its health-promoting benefits and thus widely used in various fields including pharmaceutical industry. In recent decades, the combination of collagen and KGM attracts more attentions for biomedical purpose, especially the hybrid films of collagen-KGM or collagen-KGM-polysaccharide. In this study, to further and deeply develop the intrinsic values of both collagen and KGM as biomaterials, a novel kind of composite hydrogel comprising collagen and KGM at a certain ratio was fabricated under mild conditions via fibrillogenesis process of the aqueous blends of collagen and KGM that experienced deacetylation simultaneously. The chemical composition, microcosmic architectures, swelling behavior, biodegradation and dynamic mechanic properties of such resulted composite hydrogels were systematically investigated. Biologic experiments, including cell culture
and hypodermic implantation
, were also conducted on these collagen/KGM composite hydrogels to evaluate their biologic performances. The relevant results prove that, based on collagen self-assembly behavior, this synthesis strategy is efficient to construct a composite hydrogel of collagen/KGM with improved mechanical properties, biodegradability, excellent biocompatibility and bioactivity, which are promising for potential biomedical applications such as tissue engineering and regenerative medicine. |
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AbstractList | Konjac glucomannan (KGM) is recognized as a safe material for its health-promoting benefits and thus widely used in various fields including pharmaceutical industry. In recent decades, the combination of collagen and KGM attracts more attentions for biomedical purpose, especially the hybrid films of collagen–KGM or collagen–KGM–polysaccharide. In this study, to further and deeply develop the intrinsic values of both collagen and KGM as biomaterials, a novel kind of composite hydrogel comprising collagen and KGM at a certain ratio was fabricated under mild conditions via fibrillogenesis process of the aqueous blends of collagen and KGM that experienced deacetylation simultaneously. The chemical composition, microcosmic architectures, swelling behavior, biodegradation and dynamic mechanic properties of such resulted composite hydrogels were systematically investigated. Biologic experiments, including cell culture
in vitro
and hypodermic implantation
in vivo
, were also conducted on these collagen/KGM composite hydrogels to evaluate their biologic performances. The relevant results prove that, based on collagen self-assembly behavior, this synthesis strategy is efficient to construct a composite hydrogel of collagen/KGM with improved mechanical properties, biodegradability, excellent biocompatibility and bioactivity, which are promising for potential biomedical applications such as tissue engineering and regenerative medicine. Konjac glucomannan (KGM) is recognized as a safe material for its health-promoting benefits and thus widely used in various fields including pharmaceutical industry. In recent decades, the combination of collagen and KGM attracts more attentions for biomedical purpose, especially the hybrid films of collagen-KGM or collagen-KGM-polysaccharide. In this study, to further and deeply develop the intrinsic values of both collagen and KGM as biomaterials, a novel kind of composite hydrogel comprising collagen and KGM at a certain ratio was fabricated under mild conditions via fibrillogenesis process of the aqueous blends of collagen and KGM that experienced deacetylation simultaneously. The chemical composition, microcosmic architectures, swelling behavior, biodegradation and dynamic mechanic properties of such resulted composite hydrogels were systematically investigated. Biologic experiments, including cell culture and hypodermic implantation , were also conducted on these collagen/KGM composite hydrogels to evaluate their biologic performances. The relevant results prove that, based on collagen self-assembly behavior, this synthesis strategy is efficient to construct a composite hydrogel of collagen/KGM with improved mechanical properties, biodegradability, excellent biocompatibility and bioactivity, which are promising for potential biomedical applications such as tissue engineering and regenerative medicine. |
Author | Tang, Jiayuan Fan, Hongsong Chen, Jinlin Wei, Qingrong Guo, Jing |
AuthorAffiliation | National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, P.R. China |
AuthorAffiliation_xml | – name: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, P.R. China |
Author_xml | – sequence: 1 givenname: Jiayuan surname: Tang fullname: Tang, Jiayuan organization: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, P.R. China – sequence: 2 givenname: Jinlin surname: Chen fullname: Chen, Jinlin organization: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, P.R. China – sequence: 3 givenname: Jing surname: Guo fullname: Guo, Jing organization: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, P.R. China – sequence: 4 givenname: Qingrong surname: Wei fullname: Wei, Qingrong organization: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, P.R. China – sequence: 5 givenname: Hongsong surname: Fan fullname: Fan, Hongsong organization: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, P.R. China |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30094063$$D View this record in MEDLINE/PubMed |
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Keywords | collagen self-assembly biologic evaluation fibrillogenesis composite hydrogel konjac glucomannan |
Language | English |
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Notes | Jiayuan Tang and Jinlin Chen authors contributed equally to this work. |
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Title | Construction and evaluation of fibrillar composite hydrogel of collagen/konjac glucomannan for potential biomedical applications |
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