Aquaporin-8 transports hydrogen peroxide to regulate granulosa cell autophagy

• Published in: Frontiers in cell and developmental biology Vol. 10; p. 897666
• Main Authors: Huang, Binbin, Jin, Lingling, Zhang, Luodan, Cui, Xiaolin, Zhang, Zhen, Lu, Yongqi, Yu, Lujia, Ma, Tonghui, Zhang, He
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 23.08.2022
• Subjects: AQP8; autophagy; Cell and Developmental Biology; follicular atresia; granulosa cell; hydrogen peroxide

Aquaporin-8 (AQP8), a member of the aquaporin family, is strongly expressed in follicular granulosa cells, which could affect the hormone secretion level in females. AQP8, as a membrane protein, could mediate H 2 O 2 into cells, thereby triggering various biological events. The deficiency of Aqp8 in...