Gender Differences in Cardiovascular Drugs

The different responses of women and men to cardiovascular drugs reflect gender –specific variances in pharmacokinetic profiles and drug sensitivities coupled to inherent differences in the underlying physiology of each sex. Thus, many common cardiovascular drugs exhibit gender -specific therapeutic...

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Published in	Cardiovascular drugs and therapy Vol. 29; no. 4; pp. 403 - 410
Main Authors	Stolarz, Amanda J., Rusch, Nancy J.
Format	Journal Article
Language	English
Published	New York Springer US 01.08.2015 Springer Nature B.V
Subjects	Cardiology Cardiovascular Agents - adverse effects Cardiovascular Agents - pharmacokinetics Cardiovascular Agents - pharmacology Cardiovascular Agents - therapeutic use Humans Medicine Medicine & Public Health Original Article Sex Characteristics Drugs Side effects Cardiovascular Therapeutics Medications Gender Pharmacokinetics
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ISSN	0920-3206 1573-7241 1573-7241
DOI	10.1007/s10557-015-6611-8

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Abstract	The different responses of women and men to cardiovascular drugs reflect gender –specific variances in pharmacokinetic profiles and drug sensitivities coupled to inherent differences in the underlying physiology of each sex. Thus, many common cardiovascular drugs exhibit gender -specific therapeutic and adverse effects. For example, the QT interval of the electrocardiogram is longer in women compared to men, and accordingly, drugs that prolong the QT interval are more likely to cause lethal ventricular arrhythmias in female than male patients. As more clinical drug trials include women subjects, our improved knowledge base for assessing the risk/benefit ratio for cardiovascular drugs in women will enable us to consider gender as one factor in prescribing drugs and adjusting drug loading and maintenance dosages. This short review will present evidence for gender- related differences in the responses to common cardiovascular drugs including statins, antiplatelet and antithrombotic agents, β-blockers, digoxin, vasodilator therapies, and drugs associated with the Long QT Syndrome.
AbstractList	The different responses of women and men to cardiovascular drugs reflect gender -specific variances in pharmacokinetic profiles and drug sensitivities coupled to inherent differences in the underlying physiology of each sex. Thus, many common cardiovascular drugs exhibit gender -specific therapeutic and adverse effects. For example, the QT interval of the electrocardiogram is longer in women compared to men, and accordingly, drugs that prolong the QT interval are more likely to cause lethal ventricular arrhythmias in female than male patients. As more clinical drug trials include women subjects, our improved knowledge base for assessing the risk/benefit ratio for cardiovascular drugs in women will enable us to consider gender as one factor in prescribing drugs and adjusting drug loading and maintenance dosages. This short review will present evidence for gender- related differences in the responses to common cardiovascular drugs including statins, antiplatelet and antithrombotic agents, β-blockers, digoxin, vasodilator therapies, and drugs associated with the Long QT Syndrome. Issue Title: Women and Heart Disease The different responses of women and men to cardiovascular drugs reflect gender -specific variances in pharmacokinetic profiles and drug sensitivities coupled to inherent differences in the underlying physiology of each sex. Thus, many common cardiovascular drugs exhibit gender -specific therapeutic and adverse effects. For example, the QT interval of the electrocardiogram is longer in women compared to men, and accordingly, drugs that prolong the QT interval are more likely to cause lethal ventricular arrhythmias in female than male patients. As more clinical drug trials include women subjects, our improved knowledge base for assessing the risk/benefit ratio for cardiovascular drugs in women will enable us to consider gender as one factor in prescribing drugs and adjusting drug loading and maintenance dosages. This short review will present evidence for gender- related differences in the responses to common cardiovascular drugs including statins, antiplatelet and antithrombotic agents, [beta]-blockers, digoxin, vasodilator therapies, and drugs associated with the Long QT Syndrome. The different responses of women and men to cardiovascular drugs reflect gender -specific variances in pharmacokinetic profiles and drug sensitivities coupled to inherent differences in the underlying physiology of each sex. Thus, many common cardiovascular drugs exhibit gender -specific therapeutic and adverse effects. For example, the QT interval of the electrocardiogram is longer in women compared to men, and accordingly, drugs that prolong the QT interval are more likely to cause lethal ventricular arrhythmias in female than male patients. As more clinical drug trials include women subjects, our improved knowledge base for assessing the risk/benefit ratio for cardiovascular drugs in women will enable us to consider gender as one factor in prescribing drugs and adjusting drug loading and maintenance dosages. This short review will present evidence for gender- related differences in the responses to common cardiovascular drugs including statins, antiplatelet and antithrombotic agents, β-blockers, digoxin, vasodilator therapies, and drugs associated with the Long QT Syndrome.The different responses of women and men to cardiovascular drugs reflect gender -specific variances in pharmacokinetic profiles and drug sensitivities coupled to inherent differences in the underlying physiology of each sex. Thus, many common cardiovascular drugs exhibit gender -specific therapeutic and adverse effects. For example, the QT interval of the electrocardiogram is longer in women compared to men, and accordingly, drugs that prolong the QT interval are more likely to cause lethal ventricular arrhythmias in female than male patients. As more clinical drug trials include women subjects, our improved knowledge base for assessing the risk/benefit ratio for cardiovascular drugs in women will enable us to consider gender as one factor in prescribing drugs and adjusting drug loading and maintenance dosages. This short review will present evidence for gender- related differences in the responses to common cardiovascular drugs including statins, antiplatelet and antithrombotic agents, β-blockers, digoxin, vasodilator therapies, and drugs associated with the Long QT Syndrome.
Author	Rusch, Nancy J. Stolarz, Amanda J.
Author_xml	– sequence: 1 givenname: Amanda J. surname: Stolarz fullname: Stolarz, Amanda J. email: astolarz@uams.edu organization: Department of Pharmacology and Toxicology, College of Medicine, and College of Pharmacy, University of Arkansas for Medical Sciences – sequence: 2 givenname: Nancy J. surname: Rusch fullname: Rusch, Nancy J. email: nrusch@uams.edu organization: Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences
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Snippet	The different responses of women and men to cardiovascular drugs reflect gender –specific variances in pharmacokinetic profiles and drug sensitivities coupled... The different responses of women and men to cardiovascular drugs reflect gender -specific variances in pharmacokinetic profiles and drug sensitivities coupled... Issue Title: Women and Heart Disease The different responses of women and men to cardiovascular drugs reflect gender -specific variances in pharmacokinetic...
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SubjectTerms	Cardiology Cardiovascular Agents - adverse effects Cardiovascular Agents - pharmacokinetics Cardiovascular Agents - pharmacology Cardiovascular Agents - therapeutic use Humans Medicine Medicine & Public Health Original Article Sex Characteristics
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Title	Gender Differences in Cardiovascular Drugs
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