Origin of Ovarian Cancer: Molecular Profiling
This is a review on the transition from our empirical approach to treat ovarian cancer to a specific treatment based on molecular signature. We have reviewed not only the evidence-based medicine focused on the origin and tumor morphology of ovarian cancer but also the molecular signature era based o...
Saved in:
| Published in | Journal of obstetrics and gynaecology of India Vol. 63; no. 3; pp. 152 - 157 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
India
Springer India
01.06.2013
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | This is a review on the transition from our empirical approach to treat ovarian cancer to a specific treatment based on molecular signature. We have reviewed not only the evidence-based medicine focused on the origin and tumor morphology of ovarian cancer but also the molecular signature era based on molecular phenotyping of the tumor and its microenvironment, which influences the direct targeted therapy. Evidence-based medicine has shown that the targeted therapy studies are mainly biomarker driven, more focused, and hence treat only those patients who have the underlying molecular abnormality. This molecular abnormality is the target of the drug, leading to higher rates of response. These findings will carry important implications for screening, detection, and treatment of ovarian cancer in the future. |
|---|---|
| AbstractList | This is a review on the transition from our empirical approach to treat ovarian cancer to a specific treatment based on molecular signature. We have reviewed not only the evidence-based medicine focused on the origin and tumor morphology of ovarian cancer but also the molecular signature era based on molecular phenotyping of the tumor and its microenvironment, which influences the direct targeted therapy. Evidence-based medicine has shown that the targeted therapy studies are mainly biomarker driven, more focused, and hence treat only those patients who have the underlying molecular abnormality. This molecular abnormality is the target of the drug, leading to higher rates of response. These findings will carry important implications for screening, detection, and treatment of ovarian cancer in the future. This is a review on the transition from our empirical approach to treat ovarian cancer to a specific treatment based on molecular signature. We have reviewed not only the evidence-based medicine focused on the origin and tumor morphology of ovarian cancer but also the molecular signature era based on molecular phenotyping of the tumor and its microenvironment, which influences the direct targeted therapy. Evidence-based medicine has shown that the targeted therapy studies are mainly biomarker driven, more focused, and hence treat only those patients who have the underlying molecular abnormality. This molecular abnormality is the target of the drug, leading to higher rates of response. These findings will carry important implications for screening, detection, and treatment of ovarian cancer in the future.This is a review on the transition from our empirical approach to treat ovarian cancer to a specific treatment based on molecular signature. We have reviewed not only the evidence-based medicine focused on the origin and tumor morphology of ovarian cancer but also the molecular signature era based on molecular phenotyping of the tumor and its microenvironment, which influences the direct targeted therapy. Evidence-based medicine has shown that the targeted therapy studies are mainly biomarker driven, more focused, and hence treat only those patients who have the underlying molecular abnormality. This molecular abnormality is the target of the drug, leading to higher rates of response. These findings will carry important implications for screening, detection, and treatment of ovarian cancer in the future. |
| Author | Dutta, Dilip Kumar Dutta, Indranil |
| Author_xml | – sequence: 1 givenname: Dilip Kumar surname: Dutta fullname: Dutta, Dilip Kumar email: drdilipdutta@yahoo.com organization: Gice Hospital – sequence: 2 givenname: Indranil surname: Dutta fullname: Dutta, Indranil organization: Gice Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24431628$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kUtPwzAQhC1URB_wA7igHLkY_NgkNQckVPGSisoBzpbrOMVVahc7qcq_J6WlAg6cvJLnm1nt9FHHeWcQOqXkghKSX0bKGQNMKMcEqMDrA9QjIk9xBhw6XzPFghHWRf0Y54SkOWFwhLoMgNOMDXsIT4KdWZf4MpmsVLDKJSPltAlXyZOvjG4qFZLn4EtbWTc7RoelqqI52b0D9Hp3-zJ6wOPJ_ePoZow1AKsxgFIFNZpoLUCIHMq0TKGkQlOYCtWOQxhqKJUxhRGpnpJcFZyzIjXZUGnNB-h667tspgtTaOPqoCq5DHahwof0ysrfP86-yZlfSZ6JjHJoDc53BsG_NybWcmGjNlWlnPFNlDQFQomggrTSs59Z-5DvG7UCuhXo4GMMptxLKJGbHuS2B9n2IDc9yHXL5H8YbWtVW79Z11b_kmxLxjbFzUyQc98E1177H-gTRWSdFA |
| CitedBy_id | crossref_primary_10_1007_s13224_014_0575_7 crossref_primary_10_1155_2015_321740 crossref_primary_10_1155_2015_890805 crossref_primary_10_1158_0008_5472_CAN_18_3538 crossref_primary_10_3892_ijo_2016_3678 crossref_primary_10_1007_s13277_014_2434_7 crossref_primary_10_1158_0008_5472_CAN_17_1671 crossref_primary_10_3892_mco_2015_662 |
| Cites_doi | 10.1002/ijc.25835 10.1038/nrc2886 10.1111/j.1440-1827.2006.01960.x 10.1093/jnci/90.13.995 10.1016/S0002-9440(10)62549-7 10.1002/1097-0142(20000601)88:11<2584::AID-CNCR22>3.0.CO;2-5 10.2353/ajpath.2010.100212 10.1158/0008-5472.CAN-04-2067 10.1186/1471-2407-8-17 10.1038/sj.onc.1208298 10.1186/1471-2407-9-433 10.1056/NEJMoa0810699 10.1097/01.pas.0000213335.40358.47 10.1016/j.ijgo.2007.12.012 10.1038/ncponc1178 10.1097/PAS.0b013e3181cf3d79 10.1158/1078-0432.CCR-04-2509 10.1016/j.ygyno.2010.05.012 10.1002/(SICI)1097-0142(20000215)88:4<814::AID-CNCR12>3.0.CO;2-U 10.1093/jnci/92.11.924 |
| ContentType | Journal Article |
| Copyright | Federation of Obstetric & Gynecological Societies of India 2013 |
| Copyright_xml | – notice: Federation of Obstetric & Gynecological Societies of India 2013 |
| DBID | AAYXX CITATION NPM 7X8 5PM |
| DOI | 10.1007/s13224-013-0419-x |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 0975-6434 |
| EndPage | 157 |
| ExternalDocumentID | PMC3696134 24431628 10_1007_s13224_013_0419_x |
| Genre | Journal Article Review |
| GroupedDBID | --- -EM 06D 0R~ 0VY 1N0 203 29~ 2CU 2KG 2VQ 2WC 30V 4.4 406 408 40D 96X AAAVM AACDK AAHNG AAIAL AAJBT AAJKR AANXM AANZL AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO AAYZH AAZMS ABAKF ABDZT ABECU ABFTV ABJNI ABJOX ABKCH ABMQK ABPLI ABQBU ABSXP ABTEG ABTKH ABTMW ABULA ABXPI ACAOD ACGFS ACHSB ACKNC ACMDZ ACMLO ACOKC ACPIV ACZOJ ADHHG ADHIR ADINQ ADKNI ADKPE ADQRH ADRFC ADTPH ADURQ ADYFF ADYOE ADZKW AEBTG AEFQL AEGNC AEJHL AEJRE AEMSY AEOHA AEPYU AESKC AETCA AEVLU AEXYK AFBBN AFLOW AFQWF AFWTZ AFYQB AFZKB AGAYW AGDGC AGJBK AGMZJ AGQEE AGQMX AGWZB AGYKE AHAVH AHBYD AHSBF AHYZX AIAKS AIGIU AIIXL AILAN AITGF AJBLW AJRNO AJZVZ AKMHD ALFXC ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AMXSW AMYLF AMYQR ANMIH AOCGG ASPBG AVWKF AXYYD AZFZN BGNMA CAG COF CSCUP DDRTE DNIVK DPUIP E3Z EBLON EBS EIOEI EJD EN4 ESBYG F5P FEDTE FERAY FIGPU FINBP FNLPD FRRFC FSGXE FYJPI GGCAI GGRSB GJIRD GQ6 GQ7 H13 HF~ HMJXF HRMNR HVGLF HYE HZ~ I0C IKXTQ IWAJR IXD J-C J0Z JBSCW JZLTJ KOV LLZTM M4Y NPVJJ NQJWS NU0 O9- O93 O9I O9J OK1 P9S PT4 R9I RLLFE ROL RPM RSV S1Z S27 S37 S3B SHX SISQX SJYHP SMD SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SZ9 T13 TR2 TSG U2A U9L UG4 UOJIU UTJUX UZXMN VC2 VFIZW W48 WK8 Z45 ZMTXR ZOVNA ~A9 AAPKM AAYXX ABBRH ABDBE ABFSG ACMFV ACSTC AEZWR AFDZB AFHIU AFOHR AHPBZ AHWEU AIXLP ATHPR AYFIA CITATION ABRTQ NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c442t-44aad1ec0cc949974f5f54f19c14b9a54f848c4faeede95cb07ad332d5e68acc3 |
| IEDL.DBID | U2A |
| ISSN | 0971-9202 |
| IngestDate | Thu Aug 21 13:54:32 EDT 2025 Fri Jul 11 08:41:05 EDT 2025 Mon Jul 21 05:28:54 EDT 2025 Thu Apr 24 22:57:34 EDT 2025 Tue Jul 01 03:37:45 EDT 2025 Fri Feb 21 02:26:26 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | Targeted therapy Molecular profiling Ovarian cancer |
| Language | English |
| License | http://www.springer.com/tdm |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c442t-44aad1ec0cc949974f5f54f19c14b9a54f848c4faeede95cb07ad332d5e68acc3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | https://link.springer.com/content/pdf/10.1007/s13224-013-0419-x.pdf |
| PMID | 24431628 |
| PQID | 1540109190 |
| PQPubID | 23479 |
| PageCount | 6 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3696134 proquest_miscellaneous_1540109190 pubmed_primary_24431628 crossref_primary_10_1007_s13224_013_0419_x crossref_citationtrail_10_1007_s13224_013_0419_x springer_journals_10_1007_s13224_013_0419_x |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 20130600 |
| PublicationDateYYYYMMDD | 2013-06-01 |
| PublicationDate_xml | – month: 6 year: 2013 text: 20130600 |
| PublicationDecade | 2010 |
| PublicationPlace | India |
| PublicationPlace_xml | – name: India |
| PublicationTitle | Journal of obstetrics and gynaecology of India |
| PublicationTitleAbbrev | J Obstet Gynecol India |
| PublicationTitleAlternate | J Obstet Gynaecol India |
| PublicationYear | 2013 |
| Publisher | Springer India |
| Publisher_xml | – name: Springer India |
| References | Marquez, Baggerly, Patterson (CR16) 2005; 11 Meinhold-Heerlein, Bauerschlag, Hilpert (CR15) 2005; 24 CR13 Gotlieb, Friedman, Bar-Sade (CR3) 1998; 90 Kindelberger, Lee, Miron (CR6) 2007; 31 Wong, Tsang, Deavers (CR25) 2010; 177 Rosenblatt, Thomas (CR19) 1996; 5 Signorelli, Fruscio, Lissoni (CR22) 2008; 102 Murphy, Wentzensen (CR17) 2010; 129 Ho, Kurman, Dehari (CR4) 2004; 64 Scully (CR20) 1977; 87 Singer, Kurman, Chang (CR21) 2002; 160 Vicus, Shaw, Finch (CR24) 2010; 118 Moody, Laimins (CR11) 2010; 10 Sugiyama, Kamura, Kigawa (CR23) 2000; 88 Kurman, Shih (CR5) 2008; 27 Kurman, Shih (CR7) 2010; 34 Press, De Luca, Boyd (CR18) 2008; 8 Mok, Wu, Thongprasert (CR10) 2009; 361 Lax, Kendall, Tashiro (CR9) 2000; 88 McAlpine, Wiegand, Vang (CR14) 2009; 9 Mutter, Lin, Fitzgerald (CR12) 2000; 92 Reiss, Walter, lieb (CR1) 2010; 10 Fukumoto, Nakayama (CR2) 2006; 56 Konstantinopoulos, Spentzos, Cannistra (CR8) 2008; 5 KA Rosenblatt (419_CR19) 1996; 5 CA Moody (419_CR11) 2010; 10 RE Scully (419_CR20) 1977; 87 M Signorelli (419_CR22) 2008; 102 T Sugiyama (419_CR23) 2000; 88 KK Wong (419_CR25) 2010; 177 GL Mutter (419_CR12) 2000; 92 SF Lax (419_CR9) 2000; 88 DW Kindelberger (419_CR6) 2007; 31 D Vicus (419_CR24) 2010; 118 G Singer (419_CR21) 2002; 160 MA Murphy (419_CR17) 2010; 129 RT Marquez (419_CR16) 2005; 11 JN McAlpine (419_CR14) 2009; 9 CL Ho (419_CR4) 2004; 64 JZ Press (419_CR18) 2008; 8 M Fukumoto (419_CR2) 2006; 56 I Meinhold-Heerlein (419_CR15) 2005; 24 PA Konstantinopoulos (419_CR8) 2008; 5 TS Mok (419_CR10) 2009; 361 RJ Kurman (419_CR7) 2010; 34 419_CR13 A Reiss (419_CR1) 2010; 10 WH Gotlieb (419_CR3) 1998; 90 RJ Kurman (419_CR5) 2008; 27 18342863 - Int J Gynaecol Obstet. 2008 Jul;102(1):34-8 20592731 - Nat Rev Cancer. 2010 Aug;10(8):550-60 11943707 - Am J Pathol. 2002 Apr;160(4):1223-8 16144910 - Clin Cancer Res. 2005 Sep 1;11(17):6116-26 19692680 - N Engl J Med. 2009 Sep 3;361(10):947-57 10679651 - Cancer. 2000 Feb 15;88(4):814-24 15466181 - Cancer Res. 2004 Oct 1;64(19):6915-8 8922304 - Cancer Epidemiol Biomarkers Prev. 1996 Nov;5(11):933-5 20722102 - Gynecol Oncol. 2010 Sep;118(3):295-8 17255760 - Am J Surg Pathol. 2007 Feb;31(2):161-9 18648354 - Nat Clin Pract Oncol. 2008 Oct;5(10):577-87 16669871 - Pathol Int. 2006 May;56(5):233-9 9665148 - J Natl Cancer Inst. 1998 Jul 1;90(13):995-1000 18317228 - Int J Gynecol Pathol. 2008 Apr;27(2):151-60 15558012 - Oncogene. 2005 Feb 3;24(6):1053-65 194486 - Am J Pathol. 1977 Jun;87(3):686-720 20154587 - Am J Surg Pathol. 2010 Mar;34(3):433-43 20003286 - BMC Cancer. 2009 Dec 10;9:433 18208621 - BMC Cancer. 2008 Jan 22;8:17 20802181 - Am J Pathol. 2010 Oct;177(4):1611-7 21140452 - Int J Cancer. 2011 Oct 15;129(8):1914-22 10861437 - Cancer. 2000 Jun 1;88(11):2584-9 10841828 - J Natl Cancer Inst. 2000 Jun 7;92 (11):924-30 |
| References_xml | – volume: 129 start-page: 1914 issue: 8 year: 2010 end-page: 1922 ident: CR17 article-title: Frequency of mismatch repair deficiency in ovarian cancer: a systematic review publication-title: Int J Cancer. doi: 10.1002/ijc.25835 – volume: 10 start-page: 550 year: 2010 end-page: 560 ident: CR11 article-title: Human papillomavirus oncoproteins: pathways to transformation publication-title: Nat Rev Cancer. doi: 10.1038/nrc2886 – volume: 56 start-page: 233 year: 2006 end-page: 239 ident: CR2 article-title: Ovarian epithelial tumors of low malignant potential: Are they precursors of ovarian carcinoma? publication-title: Pathol Int. doi: 10.1111/j.1440-1827.2006.01960.x – volume: 90 start-page: 995 year: 1998 end-page: 1000 ident: CR3 article-title: Rates of Jewish ancestral mutations in BRCA1 and BRCA2 in borderline ovarian tumors publication-title: J Natl Cancer Inst. doi: 10.1093/jnci/90.13.995 – volume: 160 start-page: 1223 year: 2002 end-page: 1228 ident: CR21 article-title: Diverse tumorigenic pathways in ovarian serous carcinoma publication-title: Am J Pathol. doi: 10.1016/S0002-9440(10)62549-7 – volume: 88 start-page: 2584 year: 2000 end-page: 2589 ident: CR23 article-title: Clinical characteristics of clear cell carcinoma of the ovary: a distinct histologic type with poor prognosis and resistance to platinum-based chemotherapy publication-title: Cancer. doi: 10.1002/1097-0142(20000601)88:11<2584::AID-CNCR22>3.0.CO;2-5 – volume: 177 start-page: 1611 year: 2010 end-page: 1617 ident: CR25 article-title: BRAF mutation is rare in advanced-stage low-grade ovarian serous carcinomas publication-title: Am J Pathol doi: 10.2353/ajpath.2010.100212 – volume: 64 start-page: 6915 year: 2004 end-page: 6918 ident: CR4 article-title: Mutations of BRAF and KRAS precede the development of ovarian serous borderline tumors publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-04-2067 – volume: 8 start-page: 17 year: 2008 ident: CR18 article-title: Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities publication-title: BMC Cancer. doi: 10.1186/1471-2407-8-17 – volume: 24 start-page: 1053 year: 2005 end-page: 1065 ident: CR15 article-title: Molecular and prognostic distinction between serous ovarian carcinomas of varying grade and malignant potential publication-title: Oncogene. doi: 10.1038/sj.onc.1208298 – volume: 9 start-page: 433 year: 2009 ident: CR14 article-title: HER2 overexpression and amplification is present in a subset of ovarian mucinous carcinomas and can be targeted with trastuzumab therapy publication-title: BMC Cancer. doi: 10.1186/1471-2407-9-433 – volume: 361 start-page: 947 year: 2009 end-page: 957 ident: CR10 article-title: Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma publication-title: N Engl J Med. doi: 10.1056/NEJMoa0810699 – ident: CR13 – volume: 10 start-page: 134 year: 2010 end-page: 144 ident: CR1 article-title: On the original ovarian and endometrial cancer: molecular profiling of gynecologic cancer publication-title: Recent Adv Gyne Oncol. – volume: 27 start-page: 151 year: 2008 end-page: 160 ident: CR5 article-title: Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications publication-title: Int J Gynecol Pathol. – volume: 31 start-page: 161 year: 2007 end-page: 169 ident: CR6 article-title: Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship publication-title: Am J Surg Pathol. doi: 10.1097/01.pas.0000213335.40358.47 – volume: 102 start-page: 34 year: 2008 end-page: 38 ident: CR22 article-title: Synchronous early-stage endometrial and ovarian cancer publication-title: Int J Gynaecol Obstet. doi: 10.1016/j.ijgo.2007.12.012 – volume: 5 start-page: 577 year: 2008 end-page: 587 ident: CR8 article-title: Gene-expression profiling in epithelial ovarian cancer publication-title: Nat Clin Pract Oncol. doi: 10.1038/ncponc1178 – volume: 34 start-page: 433 year: 2010 end-page: 443 ident: CR7 article-title: The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory publication-title: Am J Surg Pathol. doi: 10.1097/PAS.0b013e3181cf3d79 – volume: 87 start-page: 686 year: 1977 end-page: 720 ident: CR20 article-title: Ovarian tumors. A review publication-title: .Am J Pathol. – volume: 11 start-page: 6116 year: 2005 end-page: 6126 ident: CR16 article-title: Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon publication-title: Clin Cancer Res. doi: 10.1158/1078-0432.CCR-04-2509 – volume: 5 start-page: 933 year: 1996 end-page: 935 ident: CR19 article-title: Reduced risk of ovarian cancer in women with a tubal ligation or hysterectomy. The World Health Organization Collaborative Study of Neoplasia and Steroid Contraceptives publication-title: Cancer Epidemiol Biomarkers Prev. – volume: 118 start-page: 295 year: 2010 end-page: 298 ident: CR24 article-title: Risk factors for non-invasive lesions of the fallopian tube in BRCA mutation carriers publication-title: Gynecol Oncol. doi: 10.1016/j.ygyno.2010.05.012 – volume: 88 start-page: 814 year: 2000 end-page: 824 ident: CR9 article-title: The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: evidence of distinct molecular genetic pathways publication-title: Cancer. doi: 10.1002/(SICI)1097-0142(20000215)88:4<814::AID-CNCR12>3.0.CO;2-U – volume: 92 start-page: 924 year: 2000 end-page: 930 ident: CR12 article-title: Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers publication-title: J Natl Cancer Inst. doi: 10.1093/jnci/92.11.924 – volume: 88 start-page: 814 year: 2000 ident: 419_CR9 publication-title: Cancer. doi: 10.1002/(SICI)1097-0142(20000215)88:4<814::AID-CNCR12>3.0.CO;2-U – volume: 9 start-page: 433 year: 2009 ident: 419_CR14 publication-title: BMC Cancer. doi: 10.1186/1471-2407-9-433 – volume: 56 start-page: 233 year: 2006 ident: 419_CR2 publication-title: Pathol Int. doi: 10.1111/j.1440-1827.2006.01960.x – volume: 27 start-page: 151 year: 2008 ident: 419_CR5 publication-title: Int J Gynecol Pathol. – ident: 419_CR13 – volume: 177 start-page: 1611 year: 2010 ident: 419_CR25 publication-title: Am J Pathol doi: 10.2353/ajpath.2010.100212 – volume: 160 start-page: 1223 year: 2002 ident: 419_CR21 publication-title: Am J Pathol. doi: 10.1016/S0002-9440(10)62549-7 – volume: 118 start-page: 295 year: 2010 ident: 419_CR24 publication-title: Gynecol Oncol. doi: 10.1016/j.ygyno.2010.05.012 – volume: 102 start-page: 34 year: 2008 ident: 419_CR22 publication-title: Int J Gynaecol Obstet. doi: 10.1016/j.ijgo.2007.12.012 – volume: 11 start-page: 6116 year: 2005 ident: 419_CR16 publication-title: Clin Cancer Res. doi: 10.1158/1078-0432.CCR-04-2509 – volume: 10 start-page: 134 year: 2010 ident: 419_CR1 publication-title: Recent Adv Gyne Oncol. – volume: 5 start-page: 577 year: 2008 ident: 419_CR8 publication-title: Nat Clin Pract Oncol. doi: 10.1038/ncponc1178 – volume: 24 start-page: 1053 year: 2005 ident: 419_CR15 publication-title: Oncogene. doi: 10.1038/sj.onc.1208298 – volume: 10 start-page: 550 year: 2010 ident: 419_CR11 publication-title: Nat Rev Cancer. doi: 10.1038/nrc2886 – volume: 90 start-page: 995 year: 1998 ident: 419_CR3 publication-title: J Natl Cancer Inst. doi: 10.1093/jnci/90.13.995 – volume: 361 start-page: 947 year: 2009 ident: 419_CR10 publication-title: N Engl J Med. doi: 10.1056/NEJMoa0810699 – volume: 5 start-page: 933 year: 1996 ident: 419_CR19 publication-title: Cancer Epidemiol Biomarkers Prev. – volume: 129 start-page: 1914 issue: 8 year: 2010 ident: 419_CR17 publication-title: Int J Cancer. doi: 10.1002/ijc.25835 – volume: 88 start-page: 2584 year: 2000 ident: 419_CR23 publication-title: Cancer. doi: 10.1002/1097-0142(20000601)88:11<2584::AID-CNCR22>3.0.CO;2-5 – volume: 34 start-page: 433 year: 2010 ident: 419_CR7 publication-title: Am J Surg Pathol. doi: 10.1097/PAS.0b013e3181cf3d79 – volume: 64 start-page: 6915 year: 2004 ident: 419_CR4 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-04-2067 – volume: 92 start-page: 924 year: 2000 ident: 419_CR12 publication-title: J Natl Cancer Inst. doi: 10.1093/jnci/92.11.924 – volume: 31 start-page: 161 year: 2007 ident: 419_CR6 publication-title: Am J Surg Pathol. doi: 10.1097/01.pas.0000213335.40358.47 – volume: 8 start-page: 17 year: 2008 ident: 419_CR18 publication-title: BMC Cancer. doi: 10.1186/1471-2407-8-17 – volume: 87 start-page: 686 year: 1977 ident: 419_CR20 publication-title: .Am J Pathol. – reference: 18317228 - Int J Gynecol Pathol. 2008 Apr;27(2):151-60 – reference: 20802181 - Am J Pathol. 2010 Oct;177(4):1611-7 – reference: 18208621 - BMC Cancer. 2008 Jan 22;8:17 – reference: 18648354 - Nat Clin Pract Oncol. 2008 Oct;5(10):577-87 – reference: 15466181 - Cancer Res. 2004 Oct 1;64(19):6915-8 – reference: 21140452 - Int J Cancer. 2011 Oct 15;129(8):1914-22 – reference: 20003286 - BMC Cancer. 2009 Dec 10;9:433 – reference: 20592731 - Nat Rev Cancer. 2010 Aug;10(8):550-60 – reference: 194486 - Am J Pathol. 1977 Jun;87(3):686-720 – reference: 17255760 - Am J Surg Pathol. 2007 Feb;31(2):161-9 – reference: 9665148 - J Natl Cancer Inst. 1998 Jul 1;90(13):995-1000 – reference: 8922304 - Cancer Epidemiol Biomarkers Prev. 1996 Nov;5(11):933-5 – reference: 20722102 - Gynecol Oncol. 2010 Sep;118(3):295-8 – reference: 15558012 - Oncogene. 2005 Feb 3;24(6):1053-65 – reference: 16669871 - Pathol Int. 2006 May;56(5):233-9 – reference: 20154587 - Am J Surg Pathol. 2010 Mar;34(3):433-43 – reference: 10841828 - J Natl Cancer Inst. 2000 Jun 7;92 (11):924-30 – reference: 10679651 - Cancer. 2000 Feb 15;88(4):814-24 – reference: 19692680 - N Engl J Med. 2009 Sep 3;361(10):947-57 – reference: 11943707 - Am J Pathol. 2002 Apr;160(4):1223-8 – reference: 10861437 - Cancer. 2000 Jun 1;88(11):2584-9 – reference: 16144910 - Clin Cancer Res. 2005 Sep 1;11(17):6116-26 – reference: 18342863 - Int J Gynaecol Obstet. 2008 Jul;102(1):34-8 |
| SSID | ssj0057024 |
| Score | 1.9221957 |
| SecondaryResourceType | review_article |
| Snippet | This is a review on the transition from our empirical approach to treat ovarian cancer to a specific treatment based on molecular signature. We have reviewed... |
| SourceID | pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 152 |
| SubjectTerms | Gynecology Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Review Review Article |
| Title | Origin of Ovarian Cancer: Molecular Profiling |
| URI | https://link.springer.com/article/10.1007/s13224-013-0419-x https://www.ncbi.nlm.nih.gov/pubmed/24431628 https://www.proquest.com/docview/1540109190 https://pubmed.ncbi.nlm.nih.gov/PMC3696134 |
| Volume | 63 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3dS8MwEA-ygfgifjs_RgWflECbXJrWtzE2hzLng4P5VNIsQUE62Yf453vp2o05FXwrNA3h7pr8wt39foRcoktT62RSBTBJcZcMqQJpKIQ6UpGVoQxdv3P3Iez04W4gBkUf96Ssdi9TkvlOvWx2w9hzFROc-hDEFIFjVbirOwZxnzXK7VdIP1eyddxINGY-K1OZP02xehitIcz1Qslv2dL8EGrvkO0CPXqNubt3yYbJ9shmt8iP7xPay3WuvJH1eh94C1aZ13RuHd943VIH13vMZbpx_gPSb7eemh1aCCJQDcCmFECpYWC0r7XjlJFghRVgg1gHkMYKHyOINFiFB5-JhU59qYacs6EwYaS05oekko0yc0w8EIExqR2GXDHQkUgjzfFuxX3LtbRpVCN-aZlEF2zhTrTiLVnyHDtjJmjMxBkz-ayRq8Un73OqjL8GX5TmTjCgXZZCZWY0mySI6Vy6DoFKjRzNzb-YDrEID0KGq5MrjlkMcGTZq2-y15ecNNvpFgYcauS6dGFS_K2T31d58q_Rp2SLzcUyMMTOSGU6nplzhCzTtE6qjdvn-1Y9D9UvTPDkSg |
| linkProvider | Springer Nature |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LS8QwEA6ioF7Et-uzgicl0CaTJvUmi7I-Vj244C2k2QQF6cruKv58J912l_UF3gpNQ5iZJl-Yme8j5AhdmvsgkyqASYq7ZEoNSEchtcooL1OZhn7n9m3a6sDVo3is-rgHdbV7nZIsd-pJsxvGXqiY4DSGJKMIHOcQC6hQx9VhZ_X2K2RcKtkGbiSasZjVqcyfppg-jL4hzO-Fkl-ypeUhdLFMlir0GJ2N3L1CZlyxSubbVX58jdC7Uucq6vno7h1vwaaImsGt_dOoXevgRvelTDfOv046F-cPzRatBBGoBWBDCmBMN3E2tjZwykjwwgvwSWYTyDODjwqUBW_w4HOZsHksTZdz1hUuVcZavkFmi17htkgEInEu992UGwZWiVxZjncrHntupc9Vg8S1ZbSt2MKDaMWLnvAcB2NqNKYOxtQfDXI8_uR1RJXx1-DD2twaAzpkKUzhem8DjZgupOsQqDTI5sj84-kQi_AkZbg6OeWY8YBAlj39pnh-Kkmzg25hwqFBTmoX6upvHfy-yu1_jT4gC62H9o2-uby93iGLbCScgeG2S2aH_Te3h_BlmO-X4foJCtPlqQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LS8QwEA6isHgR367PCp6UYJtMmtabrC6-Vj244C2kaYKCdMVdxZ_vpI-V9QXeCk3SMDNNvjCT7yNkD12aOS-TKoBJiqtkTDVISyE2iU6cjGXs7zv3ruOzPlzci_ta53TYVLs3KcnqToNnaSpGh8-5O_y8-IZx6KsnOA0hSimCyBn8TuTDus-Om6VYyLBUtfU8STRlIWvSmj8NMbkxfUOb34smv2ROyw2pO0_maiQZHFeuXyBTtlgkrV6dK18i9KbUvAoGLrh5wxOxLoKOd_HLUdBrNHGD21KyG8dfJv3u6V3njNbiCNQAsBEF0DqPrAmN8fwyEpxwAlyUmgiyVONjAokBp3ETtKkwWSh1zjnLhY0TbQxfIdPFoLBrJAARWZu5POaagUlElhiO5yweOm6ky5I2CRvLKFMzh3sBiyf1yXnsjanQmMobU723yf64y3NFm_FX493G3AqD22csdGEHr0OF-M6n7hC0tMlqZf7xcIhLeBQznJ2ccMy4gSfOnnxTPD6UBNpewzDi0CYHjQtV_ecOf5_l-r9a75DW7UlXXZ1fX26QWVZpaGC0bZLp0cur3UIkM8q2y2j9AEjy6eU |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Origin+of+Ovarian+Cancer%3A+Molecular+Profiling&rft.jtitle=Journal+of+obstetrics+and+gynaecology+of+India&rft.au=Dutta%2C+Dilip+Kumar&rft.au=Dutta%2C+Indranil&rft.date=2013-06-01&rft.pub=Springer+India&rft.issn=0971-9202&rft.eissn=0975-6434&rft.volume=63&rft.issue=3&rft.spage=152&rft.epage=157&rft_id=info:doi/10.1007%2Fs13224-013-0419-x&rft.externalDocID=10_1007_s13224_013_0419_x |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0971-9202&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0971-9202&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0971-9202&client=summon |