Evaluating cholinesterases inhibition by BAC and DDAC biocides: A combined experimental and theoretical approach

• Published in: Biochimica et biophysica acta. Biomembranes Vol. 1868; no. 12; p. 130726
• Main Authors: Mouawad, Lynn, Esque, Jeremy, André, Isabelle, Istamboulie, Georges, Catanante, Gaëlle, Noguer, Thierry
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2024; Elsevier
• Subjects: Acetylcholinesterase - metabolism; Animals; Benzalkonium Compounds - chemistry; Benzalkonium Compounds - pharmacology; Biochemistry, Molecular Biology; Biocides; Butyrylcholinesterase - chemistry; Butyrylcholinesterase - metabolism; Cattle; Cholinesterase Inhibitors - chemistry; Cholinesterase Inhibitors - pharmacology; Cholinesterases; Disinfectants - pharmacology; Drosophila melanogaster - drug effects; Drosophila melanogaster - enzymology; Electrophorus; Enzyme kinetics; Erythrocytes - drug effects; Erythrocytes - enzymology; Horses; Life Sciences; Molecular docking; Molecular Docking Simulation; Quaternary Ammonium Compounds - chemistry; Quaternary Ammonium Compounds - pharmacology; Enzyme kinetics; Biocides; Molecular docking; Cholinesterases; molecular docking; biocides; enzyme kinetics

Disinfectant biocides are chemicals that are heavily used for disinfection purposes in households, hospitals, and agrifood industry. The most common type of biocides are quaternary ammonium compounds (QAs), notably benzalkonium chloride (BAC) and didecyldimethylammonium chloride (DDAC), which have b...