Adipose tissue-derived stem cells from humans and mice differ in proliferative capacity and genome stability in long-term cultures

• Published in: Stem cells and development Vol. 20; no. 4; p. 661
• Main Authors: Danoviz, Maria Elena, Bassaneze, Vinícius, Nakamuta, Juliana Sanajotti, dos Santos-Junior, Gabriel Ribeiro, Saint-Clair, Danilo, Bajgelman, Márcio Chaim, Faé, Kellen Cristhina, Kalil, Jorge, Miyakawa, Ayumi Aurea, Krieger, José Eduardo
• Format: Journal Article
• Language: English
• Published: United States 01.04.2011
• Subjects: Adipocytes - cytology; Adipose Tissue - cytology; Adult; Adult Stem Cells - cytology; Adult Stem Cells - physiology; Animals; Antigens, CD - metabolism; Cell Culture Techniques; Cell Cycle; Cell Differentiation; Cell Nucleus Shape; Cell Proliferation; Cellular Senescence; Flow Cytometry; Genomic Instability; Humans; Mice; Middle Aged; Osteocytes - cytology; Phenotype; Ploidies; Species Specificity; Time Factors

Adipose tissue-derived stem cells (ASCs) are among the more attractive adult stem cell options for potential therapeutic applications. Here, we studied and compared the basic biological characteristics of ASCs isolated from humans (hASCs) and mice (mASCs) and maintained in identical culture conditio...