Quantification of P-glycoprotein function at the human blood-brain barrier using [18F]MC225 and PET

• Published in: European journal of nuclear medicine and molecular imaging Vol. 50; no. 13; pp. 3917 - 3927
• Main Authors: Mossel, Pascalle, Arif, Wejdan M., De Souza, Giordana Salvi, Varela, Lara Garcia, van der Weijden, Chris W. J., Boersma, Hendrikus H., Willemsen, Antoon T. M., Boellaard, Ronald, Elsinga, Philip H., Borra, Ronald J. H., Dierckx, Rudi A. J. O., Lammertsma, Adriaan A., Bartels, Anna L., Luurtsema, Gert
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2023; Springer Nature B.V
• Subjects: Aged; Alzheimer's disease; ATP Binding Cassette Transporter, Subfamily B - metabolism; ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism; Blood; Blood volume; Blood-brain barrier; Blood-Brain Barrier - diagnostic imaging; Blood-Brain Barrier - metabolism; Brain - diagnostic imaging; Brain - metabolism; Cardiology; Disease resistance; Drug resistance; Efflux; Female; Females; Glycoproteins; Homeostasis; Humans; Imaging; In vivo methods and tests; Male; Males; Mathematical models; Medicine; Medicine & Public Health; Mental disorders; Metabolites; Middle Aged; Movement disorders; Neurodegenerative diseases; Nuclear Medicine; Oncology; Original; Original Article; Orthopedics; P-Glycoprotein; Parameters; Parkinson's disease; Pharmacokinetics; Positron emission; Positron-Emission Tomography; Radiology; Radiopharmaceuticals - pharmacokinetics; Rate constants; Reproducibility of Results; Substantia grisea; Substrates; Variability; Verapamil; P-glycoprotein; Test-retest; ABC-transporter; Pharmacokinetic modelling; Neuro-imaging

Introduction P-glycoprotein (P-gp) is one of the most studied efflux transporters at the blood-brain barrier. It plays an important role in brain homeostasis by protecting the brain from a variety of endogenous and exogeneous substances. Changes in P-gp function are associated both with the onset of...