Quantification of P-glycoprotein function at the human blood-brain barrier using [18F]MC225 and PET - Mossel, Pascalle; Arif, Wejdan M.; De Souza, Giordana Salvi; Varela, Lara Garcia; van der Weijden, Chris W. J.; Boersma, Hendrikus H.; Willemsen, Antoon T. M.; Boellaard, Ronald; Elsinga, Philip H.; Borra, Ronald J. H.; Dierckx, Rudi A. J. O.; Lammertsma, Adriaan A.; et al. (European journal of nuclear medicine and molecular imaging, 2023)
Keywords: Aged; Alzheimer's disease; ATP Binding Cassette Transporter, Subfamily B - metabolism; ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism; Blood; Blood volume; Blood-brain barrier; Blood-Brain Barrier - diagnostic imaging; Blood-Brain Barrier - metabolism; Brain - diagnostic imaging; Brain - metabolism; Cardiology; Disease resistance; Drug resistance; Efflux; Female; Females; Glycoproteins; Homeostasis; Humans; Imaging; In vivo methods and tests; Male; Males; Mathematical models; Medicine; Medicine & Public Health; Mental disorders; Metabolites; Middle Aged; Movement disorders; Neurodegenerative diseases; Nuclear Medicine; Oncology; Original; Original Article; Orthopedics; P-Glycoprotein; Parameters; Parkinson's disease; Pharmacokinetics; Positron emission; Positron-Emission Tomography; Radiology; Radiopharmaceuticals - pharmacokinetics; Rate constants; Reproducibility of Results; Substantia grisea; Substrates; Variability; Verapamil; P-glycoprotein; Test-retest; ABC-transporter; Pharmacokinetic modelling; Neuro-imaging