The Study of the Effect of Thiazoline Ammonium 4-Chlorophenyl-2-Hydroxy-4-Oxo-2-Butenoate on Blood Coagulation upon Intragastric and Subcutaneous Administration

• Published in: Bulletin of experimental biology and medicine Vol. 158; no. 1; pp. 46 - 48
• Main Authors: Starkova, A. V., Sobin, F. V., Syropyatov, B. Ya, Pulina, N. A.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.11.2014; Springer Nature B.V
• Subjects: Acetates - administration & dosage; Acetates - pharmacokinetics; Animals; Animals, Outbred Strains; Anticoagulants - administration & dosage; Anticoagulants - pharmacokinetics; Benzene Derivatives - administration & dosage; Benzene Derivatives - pharmacokinetics; Biomedical and Life Sciences; Biomedicine; Blood Coagulation; Cell Biology; Drug Evaluation, Preclinical; Heparin - administration & dosage; Injections, Subcutaneous; Internal Medicine; Laboratory Medicine; Pathology; Rabbits; Vinyl Compounds - administration & dosage; Vinyl Compounds - pharmacokinetics; Whole Blood Coagulation Time; thiazoline ammonium 4-chlorophenyl-2-hydroxy-4-oxo-2-butenoate; blood clotting; direct anticoagulants
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-014-2688-5

We studied the effects of subcutaneous and intragastrical administration of synthesized compound thiazoline ammonium 4-chlorophenyl-2-hydroxy-4-oxo-2-butenoate (FS 169) on blood clotting in vitro and in vivo in rabbits. Compound FS 169 significantly prolongs clotting time in vitro ; its activity is comparable with that of heparin. When administered subcutaneously, the substance is rapidly absorbed and significantly reduces blood clotting by 102.9% from the initial clotting time within 30 min. After intragastric administration of the substance, maximum activity (133.0% of the baseline clotting time) was observed in 30 min after administration. The drug effect upon subcutaneous and intragastrical administration lasted for 2 h.