Once-Only Sigmoidoscopy in Colorectal Cancer Screening: Follow-up Findings of the Italian Randomized Controlled Trial-SCORE

• Published in: JNCI : Journal of the National Cancer Institute Vol. 103; no. 17; pp. 1310 - 1322
• Main Authors: Segnan, Nereo, Armaroli, Paola, Bonelli, Luigina, Risio, Mauro, Sciallero, Stefania, Zappa, Marco, Andreoni, Bruno, Arrigoni, Arrigo, Bisanti, Luigi, Casella, Claudia, Crosta, Cristiano, Falcini, Fabio, Ferrero, Franco, Giacomin, Adriano, Giuliani, Orietta, Santarelli, Alessandra, Visioli, Carmen Beatriz, Zanetti, Roberto, Atkin, Wendy S., Senore, Carlo
• Format: Journal Article
• Language: English
• Published: Cary, NC Oxford University Press 07.09.2011; Oxford Publishing Limited (England)
• Subjects: Biological and medical sciences; Clinical outcomes; Colorectal cancer; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - mortality; Colorectal Neoplasms - prevention & control; Digestive system. Abdomen; Early Detection of Cancer - methods; Endoscopy; Female; Follow-Up Studies; Humans; Incidence; Investigative techniques, diagnostic techniques (general aspects); Italy - epidemiology; Male; Mass Screening - methods; Medical sciences; Medical screening; Middle Aged; Mortality; Odds Ratio; Patient Compliance; Sigmoidoscopy - standards; Surveys and Questionnaires; Time Factors; Tumors; Italy; Europe; Human; Rectal disease; Sigmoidoscopy; Colorectal cancer; Malignant tumor; Medical screening; Randomized controlled trial; Colonic disease; Cancerology; Follow up study; Digestive diseases; Intestinal disease; Endoscopy; Public health; Cancer

Background A single flexible sigmoidoscopy at around the age of 60 years has been proposed as an effective strategy for colorectal cancer (CRC) screening. Methods We conducted a randomized controlled trial to evaluate the effect of flexible sigmoidoscopy screening on CRC incidence and mortality. A q...