The p53–PUMA axis suppresses iPSC generation

Mechanisms underlying the reprogramming process of induced pluripotent stem cells remain poorly defined. Like tumorigenesis, generation of induced pluripotent stem cells was shown to be suppressed by the Trp53 (p53) pathway, at least in part via p21 Cdkn1a (p21)-mediated cell cycle arrest. Here we e...

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Published inNature communications Vol. 4; no. 1; p. 2174
Main Authors Li, Yanxin, Feng, Haizhong, Gu, Haihui, Lewis, Dale W., Yuan, Youzhong, Zhang, Lei, Yu, Hui, Zhang, Peng, Cheng, Haizi, Miao, Weimin, Yuan, Weiping, Cheng, Shi-Yuan, Gollin, Susanne M., Cheng, Tao
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 2013
Nature Publishing Group
Subjects
631/136/532/2064/2158
631/337
631/80/86
Animals
Apoptosis Regulatory Proteins - deficiency
Apoptosis Regulatory Proteins - genetics
Biomarkers - metabolism
Cell Cycle - genetics
Cell Differentiation
Cell Lineage - genetics
Chromosome Aberrations
Cyclin-Dependent Kinase Inhibitor p21 - deficiency
Cyclin-Dependent Kinase Inhibitor p21 - genetics
DNA Damage
Embryo, Mammalian
Female
Fibroblasts - cytology
Fibroblasts - metabolism
Gene Deletion
Gene Expression Regulation, Developmental
Humanities and Social Sciences
Induced Pluripotent Stem Cells - cytology
Induced Pluripotent Stem Cells - metabolism
Male
Mice
Mice, Transgenic
multidisciplinary
Science
Science (multidisciplinary)
Signal Transduction
Tumor Suppressor Protein p53 - deficiency
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Proteins - deficiency
Tumor Suppressor Proteins - genetics
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Abstract Mechanisms underlying the reprogramming process of induced pluripotent stem cells remain poorly defined. Like tumorigenesis, generation of induced pluripotent stem cells was shown to be suppressed by the Trp53 (p53) pathway, at least in part via p21 Cdkn1a (p21)-mediated cell cycle arrest. Here we examine the role of PUMA, a pro-apoptotic mediator of p53, during somatic reprogramming in comparison to p21 in the p53 pathway. Using mouse strains deficient in these molecules, we demonstrate that PUMA is an independent mediator of the negative effect of p53 on induced pluripotent stem cell induction. PUMA deficiency leads to a better survival rate associated with reduced DNA damage and fewer chromosomal aberrations in induced pluripotent stem cells, whereas loss of p21 or p53 results in an opposite outcome. Given these new findings, PUMA may serve as a distinct and more desirable target in the p53 pathway for induced pluripotent stem cell generation, thereby having important implications for potential therapeutic applications of induced pluripotent stem cells. Inhibition of the p53–p21 axis increases reprogramming efficiency of somatic cells into induced pluripotent stem cells (iPSCs). Here the authors show that depletion of the pro-apoptotic factor PUMA, acting downstream of p53, increases reprogramming efficiency, providing new insights into the roles of p53 in reprogramming.
AbstractList Mechanisms underlying the reprogramming process of induced pluripotent stem cells remain poorly defined. Like tumorigenesis, generation of induced pluripotent stem cells was shown to be suppressed by the Trp53 (p53) pathway, at least in part via p21 Cdkn1a (p21)-mediated cell cycle arrest. Here we examine the role of PUMA, a pro-apoptotic mediator of p53, during somatic reprogramming in comparison to p21 in the p53 pathway. Using mouse strains deficient in these molecules, we demonstrate that PUMA is an independent mediator of the negative effect of p53 on induced pluripotent stem cell induction. PUMA deficiency leads to a better survival rate associated with reduced DNA damage and fewer chromosomal aberrations in induced pluripotent stem cells, whereas loss of p21 or p53 results in an opposite outcome. Given these new findings, PUMA may serve as a distinct and more desirable target in the p53 pathway for induced pluripotent stem cell generation, thereby having important implications for potential therapeutic applications of induced pluripotent stem cells.
Mechanisms underlying the reprogramming process of induced pluripotent stem cells remain poorly defined. Like tumorigenesis, generation of induced pluripotent stem cells was shown to be suppressed by the Trp53 (p53) pathway, at least in part via p21 Cdkn1a (p21)-mediated cell cycle arrest. Here we examine the role of PUMA, a pro-apoptotic mediator of p53, during somatic reprogramming in comparison to p21 in the p53 pathway. Using mouse strains deficient in these molecules, we demonstrate that PUMA is an independent mediator of the negative effect of p53 on induced pluripotent stem cell induction. PUMA deficiency leads to a better survival rate associated with reduced DNA damage and fewer chromosomal aberrations in induced pluripotent stem cells, whereas loss of p21 or p53 results in an opposite outcome. Given these new findings, PUMA may serve as a distinct and more desirable target in the p53 pathway for induced pluripotent stem cell generation, thereby having important implications for potential therapeutic applications of induced pluripotent stem cells. Inhibition of the p53–p21 axis increases reprogramming efficiency of somatic cells into induced pluripotent stem cells (iPSCs). Here the authors show that depletion of the pro-apoptotic factor PUMA, acting downstream of p53, increases reprogramming efficiency, providing new insights into the roles of p53 in reprogramming.
Mechanisms underlying the reprogramming process of induced pluripotent stem cells remain poorly defined. Like tumorigenesis, generation of induced pluripotent stem cells was shown to be suppressed by the Trp53 (p53) pathway, at least in part via p21Cdkn1a (p21)-mediated cell cycle arrest. Here we examine the role of PUMA, a pro-apoptotic mediator of p53, during somatic reprogramming in comparison to p21 in the p53 pathway. Using mouse strains deficient in these molecules, we demonstrate that PUMA is an independent mediator of the negative effect of p53 on induced pluripotent stem cell induction. PUMA deficiency leads to a better survival rate associated with reduced DNA damage and fewer chromosomal aberrations in induced pluripotent stem cells, whereas loss of p21 or p53 results in an opposite outcome. Given these new findings, PUMA may serve as a distinct and more desirable target in the p53 pathway for induced pluripotent stem cell generation, thereby having important implications for potential therapeutic applications of induced pluripotent stem cells.
ArticleNumber 2174
Author Cheng, Haizi
Yuan, Weiping
Yu, Hui
Zhang, Peng
Gu, Haihui
Gollin, Susanne M.
Li, Yanxin
Zhang, Lei
Yuan, Youzhong
Feng, Haizhong
Cheng, Shi-Yuan
Miao, Weimin
Lewis, Dale W.
Cheng, Tao
AuthorAffiliation 1 State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing Road No. 288, Tianjin 300020, China
6 Department of Neurology, Northwestern Brain Tumor Institute, Center for Genetic Medicine, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 675 North St Clair, Chicago, Illinois 60611, USA
3 Department of Blood Transfusion, Changhai Hospital, Changhai Road No. 168, Shanghai 200433, China
4 Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, 130 De Soto Street, Pittsburgh, Pennsylvania 15261, USA
2 Stem Cell Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Dongfang Road No. 1630, Shanghai 200127, China
5 Department of Radiation Oncology, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute,
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  email: chengt@pumc.edu.cn
  organization: State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Department of Radiation Oncology, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23873265$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1038/35042675
10.1126/science.7871434
10.1038/nature09229
10.1038/onc.2009.45
10.1002/hep.24637
10.1038/emboj.2011.50
10.1038/4601085a
10.1016/j.cell.2008.01.015
10.1016/j.exphem.2011.06.004
10.1038/nature09805
10.1182/blood-2009-10-248872
10.1016/j.stem.2008.10.002
10.1016/j.cell.2009.03.034
10.1038/nature08235
10.1016/S1097-2765(01)00214-3
10.1182/blood-2009-10-248278
10.1101/gad.1940110
10.1038/ng1282
10.1158/1541-7786.MCR-11-0052
10.1038/nrg2700
10.1016/j.stem.2011.07.018
10.1016/j.stem.2010.12.003
10.1038/nprot.2007.418
10.1016/j.stem.2008.03.009
10.1126/science.1090072
10.1002/hep.24516
10.1038/cdd.2008.16
10.1101/sqb.2008.73.041
10.1158/0008-5472.CAN-09-0262
10.1038/nature08592
10.1038/nature08287
10.1038/nature09871
10.1016/j.cell.2006.07.024
10.1016/j.cell.2008.07.041
10.1016/S1097-2765(01)00213-1
10.1126/science.287.5459.1765
10.1038/nbt.1632
10.1038/nature08285
10.1016/S1535-6108(03)00244-7
10.1038/nature08290
10.1007/BF00210293
10.1016/j.stem.2012.03.002
10.1016/j.cell.2009.04.037
10.1007/s00412-004-0284-6
10.1101/gad.1940210
10.1016/j.stem.2012.02.014
10.1126/science.1092472
10.1038/nature08311
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Copyright Springer Nature Limited 2013
Copyright Nature Publishing Group Jul 2013
2013 Macmillan Publishers Limited. All rights reserved. 2013
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References Yamanaka, Blau (CR6) 2010; 465
Yamanaka (CR3) 2009; 137
Michalak (CR30) 2010; 24
Baumgartner, Villunger (CR48) 2011; 54
Marion (CR25) 2009; 460
Shen (CR44) 2011; 39
Jeffers (CR34) 2003; 4
Hoffelder (CR41) 2004; 112
Takahashi, Yamanaka (CR1) 2006; 126
Smith, Nachman, Regev, Meissner (CR8) 2010; 28
Labi (CR29) 2010; 24
Qiu (CR33) 2008; 2
Izpisua Belmonte, Ellis, Hochedlinger, Yamanaka (CR2) 2009; 10
Gore (CR12) 2011; 471
Zhao (CR23) 2008; 3
Kawamura (CR21) 2009; 460
Vogelstein, Lane, Levine (CR17) 2000; 408
Jaenisch, Young (CR5) 2008; 132
Daley (CR42) 2008; 73
Villunger (CR35) 2003; 302
Park (CR4) 2008; 134
Hanna (CR7) 2009; 462
Blasco, Serrano, Fernandez-Capetillo (CR10) 2011; 30
Carr (CR18) 2000; 287
Takahashi, Okita, Nakagawa, Yamanaka (CR36) 2007; 2
Leibowitz (CR38) 2011; 9
Young (CR13) 2012; 10
Hussein (CR11) 2011; 471
Yu (CR31) 2010; 115
Vousden, Prives (CR16) 2009; 137
Ermis (CR40) 1995; 96
Laurent (CR9) 2011; 8
Liu (CR45) 2004; 36
Nakano, Vousden (CR19) 2001; 7
Yu, Zhang (CR28) 2008; 27
Yu, Zhang, Hwang, Kinzler, Vogelstein (CR20) 2001; 7
Krizhanovsky, Lowe (CR24) 2009; 460
Qiu, Carson-Walter, Kuan, Zhang, Yu (CR47) 2009; 69
Quinlan (CR14) 2011; 9
Mekhoubad (CR15) 2012; 10
Hong (CR22) 2009; 460
Utikal (CR26) 2009; 460
Cross (CR39) 1995; 267
Vassilev (CR37) 2004; 303
Qiu (CR43) 2011; 54
Michalak, Villunger, Adams, Strasser (CR46) 2008; 15
Shao (CR32) 2010; 115
Li (CR27) 2009; 460
20436460 - Nat Biotechnol. 2010 May;28(5):521-6
21450905 - Mol Cancer Res. 2011 May;9(5):616-25
19410540 - Cell. 2009 May 1;137(3):413-31
21407252 - EMBO J. 2011 Mar 16;30(6):991-3
21898490 - Hepatology. 2011 Oct;54(4):1121-4
19668186 - Nature. 2009 Aug 27;460(7259):1140-4
19668188 - Nature. 2009 Aug 27;460(7259):1136-9
21211785 - Cell Stem Cell. 2011 Jan 7;8(1):106-18
14500851 - Science. 2003 Nov 7;302(5647):1036-8
14702042 - Nat Genet. 2004 Jan;36(1):63-8
21703985 - Exp Hematol. 2011 Sep;39(9):947-957.e1
21368825 - Nature. 2011 Mar 3;471(7336):63-7
21982236 - Cell Stem Cell. 2011 Oct 4;9(4):366-73
14704432 - Science. 2004 Feb 6;303(5659):844-8
10755928 - Science. 2000 Mar 10;287(5459):1765-6
19641508 - Oncogene. 2008 Dec;27 Suppl 1:S71-83
11099028 - Nature. 2000 Nov 16;408(6810):307-10
19345179 - Cell. 2009 Apr 3;137(1):13-7
19668189 - Nature. 2009 Aug 27;460(7259):1149-53
22542160 - Cell Stem Cell. 2012 May 4;10(5):570-82
22560080 - Cell Stem Cell. 2012 May 4;10(5):595-609
19668191 - Nature. 2009 Aug 27;460(7259):1132-5
20679396 - Genes Dev. 2010 Aug 1;24(15):1608-13
16904174 - Cell. 2006 Aug 25;126(4):663-76
19150965 - Cold Spring Harb Symp Quant Biol. 2008;73:171-4
21368824 - Nature. 2011 Mar 3;471(7336):58-62
18295576 - Cell. 2008 Feb 22;132(4):567-82
18522850 - Cell Stem Cell. 2008 Jun 5;2(6):576-83
19859062 - Nat Rev Genet. 2009 Dec;10(12):878-83
19898493 - Nature. 2009 Dec 3;462(7273):595-601
21725994 - Hepatology. 2011 Oct;54(4):1249-58
7871434 - Science. 1995 Mar 3;267(5202):1353-6
18259198 - Cell Death Differ. 2008 Jun;15(6):1019-29
20535199 - Nature. 2010 Jun 10;465(7299):704-12
19491259 - Cancer Res. 2009 Jun 15;69(12):4999-5006
18691744 - Cell. 2008 Sep 5;134(5):877-86
8522321 - Hum Genet. 1995 Dec;96(6):651-4
18983962 - Cell Stem Cell. 2008 Nov 6;3(5):475-9
11463392 - Mol Cell. 2001 Mar;7(3):683-94
19713919 - Nature. 2009 Aug 27;460(7259):1085-6
20679395 - Genes Dev. 2010 Aug 1;24(15):1602-7
20360471 - Blood. 2010 Jun 10;115(23):4707-14
19668190 - Nature. 2009 Aug 27;460(7259):1145-8
20177048 - Blood. 2010 Apr 29;115(17):3472-80
18079707 - Nat Protoc. 2007;2(12):3081-9
15156327 - Chromosoma. 2004 Jun;112(8):389-97
14585359 - Cancer Cell. 2003 Oct;4(4):321-8
11463391 - Mol Cell. 2001 Mar;7(3):673-82
RM Marion (BFncomms3174_CR25) 2009; 460
H Hong (BFncomms3174_CR22) 2009; 460
AR Quinlan (BFncomms3174_CR14) 2011; 9
GQ Daley (BFncomms3174_CR42) 2008; 73
JC Izpisua Belmonte (BFncomms3174_CR2) 2009; 10
K Takahashi (BFncomms3174_CR1) 2006; 126
Y Zhao (BFncomms3174_CR23) 2008; 3
A Ermis (BFncomms3174_CR40) 1995; 96
W Qiu (BFncomms3174_CR43) 2011; 54
W Qiu (BFncomms3174_CR47) 2009; 69
SM Cross (BFncomms3174_CR39) 1995; 267
L Shao (BFncomms3174_CR32) 2010; 115
H Shen (BFncomms3174_CR44) 2011; 39
MA Blasco (BFncomms3174_CR10) 2011; 30
A Villunger (BFncomms3174_CR35) 2003; 302
BJ Leibowitz (BFncomms3174_CR38) 2011; 9
MA Young (BFncomms3174_CR13) 2012; 10
EM Michalak (BFncomms3174_CR30) 2010; 24
A Gore (BFncomms3174_CR12) 2011; 471
T Kawamura (BFncomms3174_CR21) 2009; 460
V Krizhanovsky (BFncomms3174_CR24) 2009; 460
J Utikal (BFncomms3174_CR26) 2009; 460
J Hanna (BFncomms3174_CR7) 2009; 462
SM Hussein (BFncomms3174_CR11) 2011; 471
KH Vousden (BFncomms3174_CR16) 2009; 137
G Liu (BFncomms3174_CR45) 2004; 36
S Yamanaka (BFncomms3174_CR3) 2009; 137
JR Jeffers (BFncomms3174_CR34) 2003; 4
EM Michalak (BFncomms3174_CR46) 2008; 15
H Yu (BFncomms3174_CR31) 2010; 115
DR Hoffelder (BFncomms3174_CR41) 2004; 112
S Mekhoubad (BFncomms3174_CR15) 2012; 10
ZD Smith (BFncomms3174_CR8) 2010; 28
K Nakano (BFncomms3174_CR19) 2001; 7
J Yu (BFncomms3174_CR28) 2008; 27
S Yamanaka (BFncomms3174_CR6) 2010; 465
AM Carr (BFncomms3174_CR18) 2000; 287
LC Laurent (BFncomms3174_CR9) 2011; 8
H Li (BFncomms3174_CR27) 2009; 460
J Yu (BFncomms3174_CR20) 2001; 7
V Labi (BFncomms3174_CR29) 2010; 24
F Baumgartner (BFncomms3174_CR48) 2011; 54
IH Park (BFncomms3174_CR4) 2008; 134
B Vogelstein (BFncomms3174_CR17) 2000; 408
LT Vassilev (BFncomms3174_CR37) 2004; 303
W Qiu (BFncomms3174_CR33) 2008; 2
K Takahashi (BFncomms3174_CR36) 2007; 2
R Jaenisch (BFncomms3174_CR5) 2008; 132
References_xml – volume: 408
  start-page: 307
  year: 2000
  end-page: 310
  ident: CR17
  article-title: Surfing the p53 network
  publication-title: Nature
  doi: 10.1038/35042675
  contributor:
    fullname: Levine
– volume: 267
  start-page: 1353
  year: 1995
  end-page: 1356
  ident: CR39
  article-title: A p53-dependent mouse spindle checkpoint
  publication-title: Science
  doi: 10.1126/science.7871434
  contributor:
    fullname: Cross
– volume: 465
  start-page: 704
  year: 2010
  end-page: 712
  ident: CR6
  article-title: Nuclear reprogramming to a pluripotent state by three approaches
  publication-title: Nature
  doi: 10.1038/nature09229
  contributor:
    fullname: Blau
– volume: 27
  start-page: S71
  year: 2008
  end-page: S83
  ident: CR28
  article-title: PUMA, a potent killer with or without p53
  publication-title: Oncogene
  doi: 10.1038/onc.2009.45
  contributor:
    fullname: Zhang
– volume: 54
  start-page: 1121
  year: 2011
  end-page: 1124
  ident: CR48
  article-title: Apoptosis: a barrier against cancer no more?
  publication-title: Hepatology
  doi: 10.1002/hep.24637
  contributor:
    fullname: Villunger
– volume: 30
  start-page: 991
  year: 2011
  end-page: 993
  ident: CR10
  article-title: Genomic instability in iPS: time for a break
  publication-title: EMBO J.
  doi: 10.1038/emboj.2011.50
  contributor:
    fullname: Fernandez-Capetillo
– volume: 460
  start-page: 1085
  year: 2009
  end-page: 1086
  ident: CR24
  article-title: Stem cells: the promises and perils of p53
  publication-title: Nature
  doi: 10.1038/4601085a
  contributor:
    fullname: Lowe
– volume: 132
  start-page: 567
  year: 2008
  end-page: 582
  ident: CR5
  article-title: Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming
  publication-title: Cell
  doi: 10.1016/j.cell.2008.01.015
  contributor:
    fullname: Young
– volume: 39
  start-page: 947
  year: 2011
  end-page: 957 e941
  ident: CR44
  article-title: Bid is a positive regulator for donor-derived lymphoid cell regeneration in gamma-irradiated recipients
  publication-title: Exp. Hematol.
  doi: 10.1016/j.exphem.2011.06.004
  contributor:
    fullname: Shen
– volume: 471
  start-page: 63
  year: 2011
  end-page: 67
  ident: CR12
  article-title: Somatic coding mutations in human induced pluripotent stem cells
  publication-title: Nature
  doi: 10.1038/nature09805
  contributor:
    fullname: Gore
– volume: 115
  start-page: 4707
  year: 2010
  end-page: 4714
  ident: CR32
  article-title: Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation
  publication-title: Blood
  doi: 10.1182/blood-2009-10-248872
  contributor:
    fullname: Shao
– volume: 3
  start-page: 475
  year: 2008
  end-page: 479
  ident: CR23
  article-title: Two supporting factors greatly improve the efficiency of human iPSC generation
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2008.10.002
  contributor:
    fullname: Zhao
– volume: 137
  start-page: 13
  year: 2009
  end-page: 17
  ident: CR3
  article-title: A fresh look at iPS cells
  publication-title: Cell
  doi: 10.1016/j.cell.2009.03.034
  contributor:
    fullname: Yamanaka
– volume: 460
  start-page: 1132
  year: 2009
  end-page: 1135
  ident: CR22
  article-title: Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
  publication-title: Nature
  doi: 10.1038/nature08235
  contributor:
    fullname: Hong
– volume: 7
  start-page: 683
  year: 2001
  end-page: 694
  ident: CR19
  article-title: PUMA, a novel proapoptotic gene, is induced by p53
  publication-title: Mol. Cell
  doi: 10.1016/S1097-2765(01)00214-3
  contributor:
    fullname: Vousden
– volume: 115
  start-page: 3472
  year: 2010
  end-page: 3480
  ident: CR31
  article-title: Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation
  publication-title: Blood
  doi: 10.1182/blood-2009-10-248278
  contributor:
    fullname: Yu
– volume: 24
  start-page: 1608
  year: 2010
  end-page: 1613
  ident: CR30
  article-title: Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death
  publication-title: Gene Dev.
  doi: 10.1101/gad.1940110
  contributor:
    fullname: Michalak
– volume: 36
  start-page: 63
  year: 2004
  end-page: 68
  ident: CR45
  article-title: Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice
  publication-title: Nat. Genet.
  doi: 10.1038/ng1282
  contributor:
    fullname: Liu
– volume: 9
  start-page: 616
  year: 2011
  end-page: 625
  ident: CR38
  article-title: Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21
  publication-title: Mol. Cancer Res.
  doi: 10.1158/1541-7786.MCR-11-0052
  contributor:
    fullname: Leibowitz
– volume: 10
  start-page: 878
  year: 2009
  end-page: 883
  ident: CR2
  article-title: Induced pluripotent stem cells and reprogramming: seeing the science through the hype
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg2700
  contributor:
    fullname: Yamanaka
– volume: 9
  start-page: 366
  year: 2011
  end-page: 373
  ident: CR14
  article-title: Genome sequencing of mouse induced pluripotent stem cells reveals retroelement stability and infrequent DNA rearrangement during reprogramming
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2011.07.018
  contributor:
    fullname: Quinlan
– volume: 8
  start-page: 106
  year: 2011
  end-page: 118
  ident: CR9
  article-title: Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2010.12.003
  contributor:
    fullname: Laurent
– volume: 2
  start-page: 3081
  year: 2007
  end-page: 3089
  ident: CR36
  article-title: Induction of pluripotent stem cells from fibroblast cultures
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2007.418
  contributor:
    fullname: Yamanaka
– volume: 2
  start-page: 576
  year: 2008
  end-page: 583
  ident: CR33
  article-title: PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2008.03.009
  contributor:
    fullname: Qiu
– volume: 302
  start-page: 1036
  year: 2003
  end-page: 1038
  ident: CR35
  article-title: p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
  publication-title: Science
  doi: 10.1126/science.1090072
  contributor:
    fullname: Villunger
– volume: 54
  start-page: 1249
  year: 2011
  end-page: 1258
  ident: CR43
  article-title: PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice
  publication-title: Hepatology
  doi: 10.1002/hep.24516
  contributor:
    fullname: Qiu
– volume: 15
  start-page: 1019
  year: 2008
  end-page: 1029
  ident: CR46
  article-title: In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute
  publication-title: Cell Death Differ.
  doi: 10.1038/cdd.2008.16
  contributor:
    fullname: Strasser
– volume: 73
  start-page: 171
  year: 2008
  end-page: 174
  ident: CR42
  article-title: Common themes of dedifferentiation in somatic cell reprogramming and cancer
  publication-title: Cold Spring Harb. Symp. Quant. Biol.
  doi: 10.1101/sqb.2008.73.041
  contributor:
    fullname: Daley
– volume: 69
  start-page: 4999
  year: 2009
  end-page: 5006
  ident: CR47
  article-title: PUMA suppresses intestinal tumorigenesis in mice
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-09-0262
  contributor:
    fullname: Yu
– volume: 462
  start-page: 595
  year: 2009
  end-page: 601
  ident: CR7
  article-title: Direct cell reprogramming is a stochastic process amenable to acceleration
  publication-title: Nature
  doi: 10.1038/nature08592
  contributor:
    fullname: Hanna
– volume: 460
  start-page: 1149
  year: 2009
  end-page: 1153
  ident: CR25
  article-title: A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
  publication-title: Nature
  doi: 10.1038/nature08287
  contributor:
    fullname: Marion
– volume: 471
  start-page: 58
  year: 2011
  end-page: 62
  ident: CR11
  article-title: Copy number variation and selection during reprogramming to pluripotency
  publication-title: Nature
  doi: 10.1038/nature09871
  contributor:
    fullname: Hussein
– volume: 126
  start-page: 663
  year: 2006
  end-page: 676
  ident: CR1
  article-title: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
  publication-title: Cell
  doi: 10.1016/j.cell.2006.07.024
  contributor:
    fullname: Yamanaka
– volume: 134
  start-page: 877
  year: 2008
  end-page: 886
  ident: CR4
  article-title: Disease-specific induced pluripotent stem cells
  publication-title: Cell
  doi: 10.1016/j.cell.2008.07.041
  contributor:
    fullname: Park
– volume: 7
  start-page: 673
  year: 2001
  end-page: 682
  ident: CR20
  article-title: PUMA induces the rapid apoptosis of colorectal cancer cells
  publication-title: Mol. Cell
  doi: 10.1016/S1097-2765(01)00213-1
  contributor:
    fullname: Vogelstein
– volume: 287
  start-page: 1765
  year: 2000
  end-page: 1766
  ident: CR18
  article-title: Cell cycle. Piecing together the p53 puzzle
  publication-title: Science
  doi: 10.1126/science.287.5459.1765
  contributor:
    fullname: Carr
– volume: 28
  start-page: 521
  year: 2010
  end-page: 526
  ident: CR8
  article-title: Dynamic single-cell imaging of direct reprogramming reveals an early specifying event
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1632
  contributor:
    fullname: Meissner
– volume: 460
  start-page: 1145
  year: 2009
  end-page: 1148
  ident: CR26
  article-title: Immortalization eliminates a roadblock during cellular reprogramming into iPS cells
  publication-title: Nature
  doi: 10.1038/nature08285
  contributor:
    fullname: Utikal
– volume: 4
  start-page: 321
  year: 2003
  end-page: 328
  ident: CR34
  article-title: Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
  publication-title: Cancer Cell
  doi: 10.1016/S1535-6108(03)00244-7
  contributor:
    fullname: Jeffers
– volume: 460
  start-page: 1136
  year: 2009
  end-page: 1139
  ident: CR27
  article-title: The Ink4/Arf locus is a barrier for iPS cell reprogramming
  publication-title: Nature
  doi: 10.1038/nature08290
  contributor:
    fullname: Li
– volume: 96
  start-page: 651
  year: 1995
  end-page: 654
  ident: CR40
  article-title: Proliferation enhancement by spontaneous multiplication of chromosome 7 in rheumatic synovial cells
  publication-title: Hum. Genet.
  doi: 10.1007/BF00210293
  contributor:
    fullname: Ermis
– volume: 10
  start-page: 570
  year: 2012
  end-page: 582
  ident: CR13
  article-title: Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2012.03.002
  contributor:
    fullname: Young
– volume: 137
  start-page: 413
  year: 2009
  end-page: 431
  ident: CR16
  article-title: Blinded by the light: the growing complexity of p53
  publication-title: Cell
  doi: 10.1016/j.cell.2009.04.037
  contributor:
    fullname: Prives
– volume: 112
  start-page: 389
  year: 2004
  end-page: 397
  ident: CR41
  article-title: Resolution of anaphase bridges in cancer cells
  publication-title: Chromosoma
  doi: 10.1007/s00412-004-0284-6
  contributor:
    fullname: Hoffelder
– volume: 24
  start-page: 1602
  year: 2010
  end-page: 1607
  ident: CR29
  article-title: Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation
  publication-title: Gene Dev.
  doi: 10.1101/gad.1940210
  contributor:
    fullname: Labi
– volume: 10
  start-page: 595
  year: 2012
  end-page: 609
  ident: CR15
  article-title: Erosion of dosage compensation impacts human iPSC disease modeling
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2012.02.014
  contributor:
    fullname: Mekhoubad
– volume: 303
  start-page: 844
  year: 2004
  end-page: 848
  ident: CR37
  article-title: activation of the p53 pathway by small-molecule antagonists of MDM2
  publication-title: Science
  doi: 10.1126/science.1092472
  contributor:
    fullname: Vassilev
– volume: 460
  start-page: 1140
  year: 2009
  end-page: 1144
  ident: CR21
  article-title: Linking the p53 tumour suppressor pathway to somatic cell reprogramming
  publication-title: Nature
  doi: 10.1038/nature08311
  contributor:
    fullname: Kawamura
– volume: 126
  start-page: 663
  year: 2006
  ident: BFncomms3174_CR1
  publication-title: Cell
  doi: 10.1016/j.cell.2006.07.024
  contributor:
    fullname: K Takahashi
– volume: 408
  start-page: 307
  year: 2000
  ident: BFncomms3174_CR17
  publication-title: Nature
  doi: 10.1038/35042675
  contributor:
    fullname: B Vogelstein
– volume: 27
  start-page: S71
  year: 2008
  ident: BFncomms3174_CR28
  publication-title: Oncogene
  doi: 10.1038/onc.2009.45
  contributor:
    fullname: J Yu
– volume: 471
  start-page: 58
  year: 2011
  ident: BFncomms3174_CR11
  publication-title: Nature
  doi: 10.1038/nature09871
  contributor:
    fullname: SM Hussein
– volume: 471
  start-page: 63
  year: 2011
  ident: BFncomms3174_CR12
  publication-title: Nature
  doi: 10.1038/nature09805
  contributor:
    fullname: A Gore
– volume: 54
  start-page: 1249
  year: 2011
  ident: BFncomms3174_CR43
  publication-title: Hepatology
  doi: 10.1002/hep.24516
  contributor:
    fullname: W Qiu
– volume: 7
  start-page: 673
  year: 2001
  ident: BFncomms3174_CR20
  publication-title: Mol. Cell
  doi: 10.1016/S1097-2765(01)00213-1
  contributor:
    fullname: J Yu
– volume: 24
  start-page: 1608
  year: 2010
  ident: BFncomms3174_CR30
  publication-title: Gene Dev.
  doi: 10.1101/gad.1940110
  contributor:
    fullname: EM Michalak
– volume: 462
  start-page: 595
  year: 2009
  ident: BFncomms3174_CR7
  publication-title: Nature
  doi: 10.1038/nature08592
  contributor:
    fullname: J Hanna
– volume: 267
  start-page: 1353
  year: 1995
  ident: BFncomms3174_CR39
  publication-title: Science
  doi: 10.1126/science.7871434
  contributor:
    fullname: SM Cross
– volume: 460
  start-page: 1136
  year: 2009
  ident: BFncomms3174_CR27
  publication-title: Nature
  doi: 10.1038/nature08290
  contributor:
    fullname: H Li
– volume: 2
  start-page: 576
  year: 2008
  ident: BFncomms3174_CR33
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2008.03.009
  contributor:
    fullname: W Qiu
– volume: 39
  start-page: 947
  year: 2011
  ident: BFncomms3174_CR44
  publication-title: Exp. Hematol.
  doi: 10.1016/j.exphem.2011.06.004
  contributor:
    fullname: H Shen
– volume: 54
  start-page: 1121
  year: 2011
  ident: BFncomms3174_CR48
  publication-title: Hepatology
  doi: 10.1002/hep.24637
  contributor:
    fullname: F Baumgartner
– volume: 10
  start-page: 878
  year: 2009
  ident: BFncomms3174_CR2
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg2700
  contributor:
    fullname: JC Izpisua Belmonte
– volume: 465
  start-page: 704
  year: 2010
  ident: BFncomms3174_CR6
  publication-title: Nature
  doi: 10.1038/nature09229
  contributor:
    fullname: S Yamanaka
– volume: 9
  start-page: 616
  year: 2011
  ident: BFncomms3174_CR38
  publication-title: Mol. Cancer Res.
  doi: 10.1158/1541-7786.MCR-11-0052
  contributor:
    fullname: BJ Leibowitz
– volume: 303
  start-page: 844
  year: 2004
  ident: BFncomms3174_CR37
  publication-title: Science
  doi: 10.1126/science.1092472
  contributor:
    fullname: LT Vassilev
– volume: 9
  start-page: 366
  year: 2011
  ident: BFncomms3174_CR14
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2011.07.018
  contributor:
    fullname: AR Quinlan
– volume: 36
  start-page: 63
  year: 2004
  ident: BFncomms3174_CR45
  publication-title: Nat. Genet.
  doi: 10.1038/ng1282
  contributor:
    fullname: G Liu
– volume: 3
  start-page: 475
  year: 2008
  ident: BFncomms3174_CR23
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2008.10.002
  contributor:
    fullname: Y Zhao
– volume: 287
  start-page: 1765
  year: 2000
  ident: BFncomms3174_CR18
  publication-title: Science
  doi: 10.1126/science.287.5459.1765
  contributor:
    fullname: AM Carr
– volume: 30
  start-page: 991
  year: 2011
  ident: BFncomms3174_CR10
  publication-title: EMBO J.
  doi: 10.1038/emboj.2011.50
  contributor:
    fullname: MA Blasco
– volume: 96
  start-page: 651
  year: 1995
  ident: BFncomms3174_CR40
  publication-title: Hum. Genet.
  doi: 10.1007/BF00210293
  contributor:
    fullname: A Ermis
– volume: 134
  start-page: 877
  year: 2008
  ident: BFncomms3174_CR4
  publication-title: Cell
  doi: 10.1016/j.cell.2008.07.041
  contributor:
    fullname: IH Park
– volume: 15
  start-page: 1019
  year: 2008
  ident: BFncomms3174_CR46
  publication-title: Cell Death Differ.
  doi: 10.1038/cdd.2008.16
  contributor:
    fullname: EM Michalak
– volume: 7
  start-page: 683
  year: 2001
  ident: BFncomms3174_CR19
  publication-title: Mol. Cell
  doi: 10.1016/S1097-2765(01)00214-3
  contributor:
    fullname: K Nakano
– volume: 2
  start-page: 3081
  year: 2007
  ident: BFncomms3174_CR36
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2007.418
  contributor:
    fullname: K Takahashi
– volume: 137
  start-page: 413
  year: 2009
  ident: BFncomms3174_CR16
  publication-title: Cell
  doi: 10.1016/j.cell.2009.04.037
  contributor:
    fullname: KH Vousden
– volume: 460
  start-page: 1085
  year: 2009
  ident: BFncomms3174_CR24
  publication-title: Nature
  doi: 10.1038/4601085a
  contributor:
    fullname: V Krizhanovsky
– volume: 115
  start-page: 3472
  year: 2010
  ident: BFncomms3174_CR31
  publication-title: Blood
  doi: 10.1182/blood-2009-10-248278
  contributor:
    fullname: H Yu
– volume: 10
  start-page: 570
  year: 2012
  ident: BFncomms3174_CR13
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2012.03.002
  contributor:
    fullname: MA Young
– volume: 460
  start-page: 1132
  year: 2009
  ident: BFncomms3174_CR22
  publication-title: Nature
  doi: 10.1038/nature08235
  contributor:
    fullname: H Hong
– volume: 115
  start-page: 4707
  year: 2010
  ident: BFncomms3174_CR32
  publication-title: Blood
  doi: 10.1182/blood-2009-10-248872
  contributor:
    fullname: L Shao
– volume: 112
  start-page: 389
  year: 2004
  ident: BFncomms3174_CR41
  publication-title: Chromosoma
  doi: 10.1007/s00412-004-0284-6
  contributor:
    fullname: DR Hoffelder
– volume: 460
  start-page: 1149
  year: 2009
  ident: BFncomms3174_CR25
  publication-title: Nature
  doi: 10.1038/nature08287
  contributor:
    fullname: RM Marion
– volume: 302
  start-page: 1036
  year: 2003
  ident: BFncomms3174_CR35
  publication-title: Science
  doi: 10.1126/science.1090072
  contributor:
    fullname: A Villunger
– volume: 460
  start-page: 1145
  year: 2009
  ident: BFncomms3174_CR26
  publication-title: Nature
  doi: 10.1038/nature08285
  contributor:
    fullname: J Utikal
– volume: 4
  start-page: 321
  year: 2003
  ident: BFncomms3174_CR34
  publication-title: Cancer Cell
  doi: 10.1016/S1535-6108(03)00244-7
  contributor:
    fullname: JR Jeffers
– volume: 132
  start-page: 567
  year: 2008
  ident: BFncomms3174_CR5
  publication-title: Cell
  doi: 10.1016/j.cell.2008.01.015
  contributor:
    fullname: R Jaenisch
– volume: 137
  start-page: 13
  year: 2009
  ident: BFncomms3174_CR3
  publication-title: Cell
  doi: 10.1016/j.cell.2009.03.034
  contributor:
    fullname: S Yamanaka
– volume: 8
  start-page: 106
  year: 2011
  ident: BFncomms3174_CR9
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2010.12.003
  contributor:
    fullname: LC Laurent
– volume: 10
  start-page: 595
  year: 2012
  ident: BFncomms3174_CR15
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2012.02.014
  contributor:
    fullname: S Mekhoubad
– volume: 24
  start-page: 1602
  year: 2010
  ident: BFncomms3174_CR29
  publication-title: Gene Dev.
  doi: 10.1101/gad.1940210
  contributor:
    fullname: V Labi
– volume: 69
  start-page: 4999
  year: 2009
  ident: BFncomms3174_CR47
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-09-0262
  contributor:
    fullname: W Qiu
– volume: 460
  start-page: 1140
  year: 2009
  ident: BFncomms3174_CR21
  publication-title: Nature
  doi: 10.1038/nature08311
  contributor:
    fullname: T Kawamura
– volume: 28
  start-page: 521
  year: 2010
  ident: BFncomms3174_CR8
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1632
  contributor:
    fullname: ZD Smith
– volume: 73
  start-page: 171
  year: 2008
  ident: BFncomms3174_CR42
  publication-title: Cold Spring Harb. Symp. Quant. Biol.
  doi: 10.1101/sqb.2008.73.041
  contributor:
    fullname: GQ Daley
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Snippet Mechanisms underlying the reprogramming process of induced pluripotent stem cells remain poorly defined. Like tumorigenesis, generation of induced pluripotent...
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StartPage 2174
SubjectTerms 631/136/532/2064/2158
631/337
631/80/86
Animals
Apoptosis Regulatory Proteins - deficiency
Apoptosis Regulatory Proteins - genetics
Biomarkers - metabolism
Cell Cycle - genetics
Cell Differentiation
Cell Lineage - genetics
Chromosome Aberrations
Cyclin-Dependent Kinase Inhibitor p21 - deficiency
Cyclin-Dependent Kinase Inhibitor p21 - genetics
DNA Damage
Embryo, Mammalian
Female
Fibroblasts - cytology
Fibroblasts - metabolism
Gene Deletion
Gene Expression Regulation, Developmental
Humanities and Social Sciences
Induced Pluripotent Stem Cells - cytology
Induced Pluripotent Stem Cells - metabolism
Male
Mice
Mice, Transgenic
multidisciplinary
Science
Science (multidisciplinary)
Signal Transduction
Tumor Suppressor Protein p53 - deficiency
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Proteins - deficiency
Tumor Suppressor Proteins - genetics
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Title The p53–PUMA axis suppresses iPSC generation
URI https://link.springer.com/article/10.1038/ncomms3174
https://www.ncbi.nlm.nih.gov/pubmed/23873265
https://www.proquest.com/docview/1406196109
https://pubmed.ncbi.nlm.nih.gov/PMC4394110
Volume 4
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