Genotyping serotonin transporter polymorphisms 5-HTTLPR and rs25531 in European- and African-American subjects from the National Institute of Mental Health’s Collaborative Center for Genomic Studies

• Published in: Translational psychiatry Vol. 3; no. 9; p. e307
• Main Authors: Odgerel, Z, Talati, A, Hamilton, S P, Levinson, D F, Weissman, M M
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2013; Nature Publishing Group
• Subjects: 631/208/457/649; 631/92/577; 692/699/476/1414; African Americans - genetics; Behavioral Sciences; Biological Psychology; European Continental Ancestry Group - genetics; Gene Frequency; Genotype; Humans; Medicine; Medicine & Public Health; National Institute of Mental Health (U.S.); Neurosciences; Original; original-article; Pharmacotherapy; Polymorphism, Single Nucleotide; Psychiatry; Serotonin Plasma Membrane Transport Proteins - genetics; United States; United States; rs25531; 5-HTTLPR; African-American; serotonin transporter; major depression

A number of studies have suggested DNA sequence variability in the serotonin transporter gene ( SLC6A4 ) between European-American (EA) and African-American (AA) populations, which could be clinically important, given the central role SLC6A4 has in serotonin transmission. However, these studies have...