Potential Role of S-Palmitoylation in Cancer Stem Cells of Lung Adenocarcinoma
S-palmitoylation, catalyzed by a family of 23 zinc finger Asp-His-His-Cys (DHHC) domain-containing (ZDHHC) protein acyltransferases localized on the cell membrane. However, stemness genes modulated by ZDHHCs in lung adenocarcinoma (LUAD) remain to be defined. Previously, we have constructed a networ...
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| Published in | Frontiers in cell and developmental biology Vol. 9; p. 734897 |
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| Format | Journal Article |
| Language | English |
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21.09.2021
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| Abstract | S-palmitoylation, catalyzed by a family of 23 zinc finger Asp-His-His-Cys (DHHC) domain-containing (ZDHHC) protein acyltransferases localized on the cell membrane. However, stemness genes modulated by ZDHHCs in lung adenocarcinoma (LUAD) remain to be defined. Previously, we have constructed a network of cancer stem cell genes, including INCENP, based on mRNA stemness indices (mRNAsi) of LUAD. INCENP has the function of a chromosomal passenger complex locating to centromeres, which is performed by the conserved region of its N-terminal domain. INCENP protein with a deletion of the first non-conserved 26 amino acid sequence failed to target centromeres. However, the exact function of the deleted sequence has not been elucidated. To identify novel cancer stem cell-relevant palmitoylated proteins and responsible ZDHHC enzymes in LUAD, we analyzed multi-omics data obtained from the database of The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Clinical Proteomic Tumor Analysis Consortium (CPTAC), and the Human Protein Atlas (HPA). ZDHHC5 is distinguished from the ZDHHC family for being up-regulated in mRNA and protein levels and associated with malignant prognosis. ZDHHC5 was positively associated with INCENP, and the correlation score increased with LUAD stages. CSS-Palm results showed Cys
15
was the S-palmitoylation site of INCENP. Interestingly, Cys
15
locates in the 1–26 aa sequence of INCENP, and is a conserved site across species. As INCENP is a nuclear protein, we predicted that the nuclear localization signal of ZDHHC5 was specific to the importin αβ pathway, and the result of immunofluorescence proves that ZDHHC5 is located in the nucleoplasm, in addition to the plasma membrane. Therefore, our study indicates the S-palmitoylation of INCENP mediated by ZDHHC5 as a potential mechanism of S-palmitoylation to modulate CSCs in LUAD. |
|---|---|
| AbstractList | S-palmitoylation, catalyzed by a family of 23 zinc finger Asp-His-His-Cys (DHHC) domain-containing (ZDHHC) protein acyltransferases localized on the cell membrane. However, stemness genes modulated by ZDHHCs in lung adenocarcinoma (LUAD) remain to be defined. Previously, we have constructed a network of cancer stem cell genes, including INCENP, based on mRNA stemness indices (mRNAsi) of LUAD. INCENP has the function of a chromosomal passenger complex locating to centromeres, which is performed by the conserved region of its N-terminal domain. INCENP protein with a deletion of the first non-conserved 26 amino acid sequence failed to target centromeres. However, the exact function of the deleted sequence has not been elucidated. To identify novel cancer stem cell-relevant palmitoylated proteins and responsible ZDHHC enzymes in LUAD, we analyzed multi-omics data obtained from the database of The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Clinical Proteomic Tumor Analysis Consortium (CPTAC), and the Human Protein Atlas (HPA). ZDHHC5 is distinguished from the ZDHHC family for being up-regulated in mRNA and protein levels and associated with malignant prognosis. ZDHHC5 was positively associated with INCENP, and the correlation score increased with LUAD stages. CSS-Palm results showed Cys
15
was the S-palmitoylation site of INCENP. Interestingly, Cys
15
locates in the 1–26 aa sequence of INCENP, and is a conserved site across species. As INCENP is a nuclear protein, we predicted that the nuclear localization signal of ZDHHC5 was specific to the importin αβ pathway, and the result of immunofluorescence proves that ZDHHC5 is located in the nucleoplasm, in addition to the plasma membrane. Therefore, our study indicates the S-palmitoylation of INCENP mediated by ZDHHC5 as a potential mechanism of S-palmitoylation to modulate CSCs in LUAD. S-palmitoylation, catalyzed by a family of 23 zinc finger Asp-His-His-Cys (DHHC) domain-containing (ZDHHC) protein acyltransferases localized on the cell membrane. However, stemness genes modulated by ZDHHCs in lung adenocarcinoma (LUAD) remain to be defined. Previously, we have constructed a network of cancer stem cell genes, including INCENP, based on mRNA stemness indices (mRNAsi) of LUAD. INCENP has the function of a chromosomal passenger complex locating to centromeres, which is performed by the conserved region of its N-terminal domain. INCENP protein with a deletion of the first non-conserved 26 amino acid sequence failed to target centromeres. However, the exact function of the deleted sequence has not been elucidated. To identify novel cancer stem cell-relevant palmitoylated proteins and responsible ZDHHC enzymes in LUAD, we analyzed multi-omics data obtained from the database of The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Clinical Proteomic Tumor Analysis Consortium (CPTAC), and the Human Protein Atlas (HPA). ZDHHC5 is distinguished from the ZDHHC family for being up-regulated in mRNA and protein levels and associated with malignant prognosis. ZDHHC5 was positively associated with INCENP, and the correlation score increased with LUAD stages. CSS-Palm results showed Cys15 was the S-palmitoylation site of INCENP. Interestingly, Cys15 locates in the 1–26 aa sequence of INCENP, and is a conserved site across species. As INCENP is a nuclear protein, we predicted that the nuclear localization signal of ZDHHC5 was specific to the importin αβ pathway, and the result of immunofluorescence proves that ZDHHC5 is located in the nucleoplasm, in addition to the plasma membrane. Therefore, our study indicates the S-palmitoylation of INCENP mediated by ZDHHC5 as a potential mechanism of S-palmitoylation to modulate CSCs in LUAD. S-palmitoylation, catalyzed by a family of 23 zinc finger Asp-His-His-Cys (DHHC) domain-containing (ZDHHC) protein acyltransferases localized on the cell membrane. However, stemness genes modulated by ZDHHCs in lung adenocarcinoma (LUAD) remain to be defined. Previously, we have constructed a network of cancer stem cell genes, including INCENP, based on mRNA stemness indices (mRNAsi) of LUAD. INCENP has the function of a chromosomal passenger complex locating to centromeres, which is performed by the conserved region of its N-terminal domain. INCENP protein with a deletion of the first non-conserved 26 amino acid sequence failed to target centromeres. However, the exact function of the deleted sequence has not been elucidated. To identify novel cancer stem cell-relevant palmitoylated proteins and responsible ZDHHC enzymes in LUAD, we analyzed multi-omics data obtained from the database of The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Clinical Proteomic Tumor Analysis Consortium (CPTAC), and the Human Protein Atlas (HPA). ZDHHC5 is distinguished from the ZDHHC family for being up-regulated in mRNA and protein levels and associated with malignant prognosis. ZDHHC5 was positively associated with INCENP, and the correlation score increased with LUAD stages. CSS-Palm results showed Cys15 was the S-palmitoylation site of INCENP. Interestingly, Cys15 locates in the 1-26 aa sequence of INCENP, and is a conserved site across species. As INCENP is a nuclear protein, we predicted that the nuclear localization signal of ZDHHC5 was specific to the importin αβ pathway, and the result of immunofluorescence proves that ZDHHC5 is located in the nucleoplasm, in addition to the plasma membrane. Therefore, our study indicates the S-palmitoylation of INCENP mediated by ZDHHC5 as a potential mechanism of S-palmitoylation to modulate CSCs in LUAD.S-palmitoylation, catalyzed by a family of 23 zinc finger Asp-His-His-Cys (DHHC) domain-containing (ZDHHC) protein acyltransferases localized on the cell membrane. However, stemness genes modulated by ZDHHCs in lung adenocarcinoma (LUAD) remain to be defined. Previously, we have constructed a network of cancer stem cell genes, including INCENP, based on mRNA stemness indices (mRNAsi) of LUAD. INCENP has the function of a chromosomal passenger complex locating to centromeres, which is performed by the conserved region of its N-terminal domain. INCENP protein with a deletion of the first non-conserved 26 amino acid sequence failed to target centromeres. However, the exact function of the deleted sequence has not been elucidated. To identify novel cancer stem cell-relevant palmitoylated proteins and responsible ZDHHC enzymes in LUAD, we analyzed multi-omics data obtained from the database of The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Clinical Proteomic Tumor Analysis Consortium (CPTAC), and the Human Protein Atlas (HPA). ZDHHC5 is distinguished from the ZDHHC family for being up-regulated in mRNA and protein levels and associated with malignant prognosis. ZDHHC5 was positively associated with INCENP, and the correlation score increased with LUAD stages. CSS-Palm results showed Cys15 was the S-palmitoylation site of INCENP. Interestingly, Cys15 locates in the 1-26 aa sequence of INCENP, and is a conserved site across species. As INCENP is a nuclear protein, we predicted that the nuclear localization signal of ZDHHC5 was specific to the importin αβ pathway, and the result of immunofluorescence proves that ZDHHC5 is located in the nucleoplasm, in addition to the plasma membrane. Therefore, our study indicates the S-palmitoylation of INCENP mediated by ZDHHC5 as a potential mechanism of S-palmitoylation to modulate CSCs in LUAD. |
| Author | Li, Fenglan Lien, I-Chia Li, Hui Liu, Xiqing Fu, Kexin Zhang, Yitong |
| AuthorAffiliation | 3 The State Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications , Beijing , China 4 Insight Genomics Inc., National Cheng Kung University , Tainan , Taiwan 1 Department of Biochemistry and Molecular Biology, Harbin Medical University , Harbin , China 2 Department of Gastrointestinal, The First Hospital of Jilin University , Changchun , China |
| AuthorAffiliation_xml | – name: 1 Department of Biochemistry and Molecular Biology, Harbin Medical University , Harbin , China – name: 3 The State Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications , Beijing , China – name: 2 Department of Gastrointestinal, The First Hospital of Jilin University , Changchun , China – name: 4 Insight Genomics Inc., National Cheng Kung University , Tainan , Taiwan |
| Author_xml | – sequence: 1 givenname: Yitong surname: Zhang fullname: Zhang, Yitong – sequence: 2 givenname: Fenglan surname: Li fullname: Li, Fenglan – sequence: 3 givenname: Kexin surname: Fu fullname: Fu, Kexin – sequence: 4 givenname: Xiqing surname: Liu fullname: Liu, Xiqing – sequence: 5 givenname: I-Chia surname: Lien fullname: Lien, I-Chia – sequence: 6 givenname: Hui surname: Li fullname: Li, Hui |
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| CitedBy_id | crossref_primary_10_1007_s11030_023_10633_7 crossref_primary_10_1080_07391102_2024_2306502 crossref_primary_10_1007_s11626_023_00755_5 crossref_primary_10_14336_AD_2023_0121 crossref_primary_10_3390_biom12111655 crossref_primary_10_3389_fendo_2022_992875 crossref_primary_10_1016_j_celrep_2024_113720 crossref_primary_10_1007_s10555_024_10217_3 crossref_primary_10_1111_cas_16085 crossref_primary_10_1038_s41598_025_90858_8 crossref_primary_10_1002_cam4_6345 |
| Cites_doi | 10.1016/j.cllc.2019.02.005 10.1126/science.1260419 10.1083/jcb.143.7.1763 10.1126/science.aal3321 10.1042/BST20160233 10.1016/j.semcancer.2018.09.006 10.1091/mbc.e05-12-1133 10.1126/science.aan2507 10.1074/jbc.M111.306183 10.1038/nchembio.2036 10.1201/9780203486283.ch5 10.3390/genes11030257 10.1093/bioinformatics/btz210 10.1074/mcp.M500279-MCP200 10.1038/s41388-018-0588-2 10.15252/emmm.201708313 10.1038/nm.1790 10.1093/protein/gzn039 10.1158/1541-7786 10.1074/mcp.M110.001198 10.1038/nature13385 10.1016/j.apsb.2020.03.008 10.1016/j.lungcan.2014.01.009 10.1016/j.cell.2018.03.034 10.1016/s0005-2760(98)00130-1 10.4161/cc.9.7.11177 10.3390/ijms19123820 10.1016/j.omto.2020.05.007 10.1016/j.path.2019.11.002 10.1097/JTO.0000000000000630 10.1159/000455160 10.7150/thno.40076 10.1074/jbc.M104013200 10.1093/nar/gkx1090 10.1016/j.tibs.2017.04.004 10.1021/acs.chemrev.6b00750 10.1158/0008-5472.CAN-17-1139 10.2147/OTT.S81328 10.1073/pnas.0506580102 10.1038/nn.2671 10.3389/fonc.2020.565414 10.15252/embr.201846666 10.3390/ijms21134569 10.1186/s13046-019-1033-2 10.1142/9789814749411_0037 10.1016/j.immuni.2018.03.023 10.1038/sj.embor.7400562 10.1016/j.pmu.2015.03.007 |
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| References | Ruiz-Cordero (B31) 2020; 13 Uhlén (B40) 2005; 4 Jiang (B14) 2018; 118 Chen (B7); 10 Wadowska (B45) 2020; 21 Kuhn (B17) 2018; 110 Li (B20) 2012; 287 Maccalli (B23) 2018; 53 Xia (B47) 2015; 8 Wilson (B46) 2011; 10 Percherancier (B26) 2001; 276 Zhang (B49) 2020; 11 Shedden (B32) 2008; 14 Tian (B38) 2015; 13 Yuan (B48) 2020; 10 Leão (B19) 2017; 99 Sokolov (B33) 2016; 21 Ko (B16) 2018; 19 Vasaikar (B44) 2018; 46 Ren (B27) 2008; 21 Uhlén (B41) 2015; 347 Subramanian (B35) 2005; 102 Riccio (B29) 2010; 13 Ainsztein (B1) 1998; 143 Dunphy (B12) 1998; 1436 Chen (B9); 17 Fukata (B13) 2006 Klein (B15) 2006; 17 Chen (B10) 2017; 77 Uhlen (B42) 2017; 357 (B5) 2014; 511 Vader (B43) 2006; 7 Miyata (B25) 2015; 4 Thorsson (B36) 2018; 48 Lanyon-Hogg (B18) 2017; 42 Ali (B2) 2018; 10 Chen (B8) 2019; 38 Thul (B37) 2017; 356 Spinelli (B34) 2018; 19 Resh (B28) 2017; 45 Travis (B39) 2015; 10 Chan (B6) 2016; 12 Codony-Servat (B11) 2019; 20 Lortet-Tieulent (B22) 2014; 84 Ru (B30) 2019; 35 Cai (B4) 2019; 38 Malta (B24) 2018; 173 Becker (B3) 2010; 9 Liu (B21) 2020; 10 |
| References_xml | – volume: 20 start-page: 167 year: 2019 ident: B11 article-title: Cancer Stem Cell Biomarkers in EGFR-Mutation-Positive Non-Small-Cell Lung Cancer. publication-title: Clin. Lung Cancer doi: 10.1016/j.cllc.2019.02.005 – volume: 347 start-page: 1260419 year: 2015 ident: B41 article-title: Proteomics. Tissue-based map of the human proteome. publication-title: Science doi: 10.1126/science.1260419 – volume: 143 start-page: 1763 year: 1998 ident: B1 article-title: INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1. publication-title: J. Cell Biol. doi: 10.1083/jcb.143.7.1763 – volume: 356 start-page: eaal3321 year: 2017 ident: B37 article-title: A subcellular map of the human proteome. publication-title: Science doi: 10.1126/science.aal3321 – volume: 45 start-page: 409 year: 2017 ident: B28 article-title: Palmitoylation of proteins in cancer. publication-title: Biochem. Soc. Trans. doi: 10.1042/BST20160233 – volume: 53 start-page: 189 year: 2018 ident: B23 article-title: The role of cancer stem cells in the modulation of anti-tumor immune responses. publication-title: Semin. Cancer Biol. doi: 10.1016/j.semcancer.2018.09.006 – volume: 17 start-page: 2547 year: 2006 ident: B15 article-title: Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP. publication-title: Mol. Biol. Cell doi: 10.1091/mbc.e05-12-1133 – volume: 357 start-page: eaan2507 year: 2017 ident: B42 article-title: A pathology atlas of the human cancer transcriptome. publication-title: Science doi: 10.1126/science.aan2507 – volume: 287 start-page: 523 year: 2012 ident: B20 article-title: DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells. publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.306183 – volume: 12 start-page: 282 year: 2016 ident: B6 article-title: Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway. publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.2036 – start-page: 83 year: 2006 ident: B13 article-title: Protein Palmitoylation by DHHC Protein Family publication-title: The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology doi: 10.1201/9780203486283.ch5 – volume: 11 start-page: 257 year: 2020 ident: B49 article-title: mRNAsi Index: machine Learning in Mining Lung Adenocarcinoma Stem Cell Biomarkers. publication-title: Genes doi: 10.3390/genes11030257 – volume: 35 start-page: 4200 year: 2019 ident: B30 article-title: TISIDB: an integrated repository portal for tumor-immune system interactions. publication-title: Bioinformatics doi: 10.1093/bioinformatics/btz210 – volume: 4 start-page: 1920 year: 2005 ident: B40 article-title: A human protein atlas for normal and cancer tissues based on antibody proteomics. publication-title: Mol. Cell Proteomics doi: 10.1074/mcp.M500279-MCP200 – volume: 38 start-page: 2551 year: 2019 ident: B4 article-title: LCE: an open web portal to explore gene expression and clinical associations in lung cancer. publication-title: Oncogene doi: 10.1038/s41388-018-0588-2 – volume: 10 start-page: e8313 year: 2018 ident: B2 article-title: Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer. publication-title: EMBO Mol. Med. doi: 10.15252/emmm.201708313 – volume: 14 start-page: 822 year: 2008 ident: B32 article-title: Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study. publication-title: Nat. Med. doi: 10.1038/nm.1790 – volume: 21 start-page: 639 year: 2008 ident: B27 article-title: CSS-Palm 2.0: an updated software for palmitoylation sites prediction. publication-title: Protein Eng. Des. Sel. doi: 10.1093/protein/gzn039 – volume: 13 start-page: 784 year: 2015 ident: B38 article-title: Systematic siRNA Screen Unmasks NSCLC Growth Dependence by Palmitoyltransferase DHHC5. publication-title: Mol. Cancer Res. doi: 10.1158/1541-7786 – volume: 10 start-page: M110.001198 year: 2011 ident: B46 article-title: Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants. publication-title: Mol. Cell Proteomics doi: 10.1074/mcp.M110.001198 – volume: 511 start-page: 543 year: 2014 ident: B5 article-title: Comprehensive molecular profiling of lung adenocarcinoma. publication-title: Nature doi: 10.1038/nature13385 – volume: 10 start-page: 1426 year: 2020 ident: B48 article-title: ZDHHC12-mediated claudin-3 S-palmitoylation determines ovarian cancer progression. publication-title: Acta Pharm. Sin. B. doi: 10.1016/j.apsb.2020.03.008 – volume: 84 start-page: 13 year: 2014 ident: B22 article-title: International trends in lung cancer incidence by histological subtype: adenocarcinoma stabilizing in men but still increasing in women. publication-title: Lung Cancer doi: 10.1016/j.lungcan.2014.01.009 – volume: 173 start-page: 338 year: 2018 ident: B24 article-title: Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation. publication-title: Cell doi: 10.1016/j.cell.2018.03.034 – volume: 1436 start-page: 245 year: 1998 ident: B12 article-title: Signalling functions of protein palmitoylation. publication-title: Biochim. Biophys. Acta doi: 10.1016/s0005-2760(98)00130-1 – volume: 9 start-page: 1360 year: 2010 ident: B3 article-title: Centromere localization of INCENP-Aurora B is sufficient to support spindle checkpoint function. publication-title: Cell Cycle doi: 10.4161/cc.9.7.11177 – volume: 19 start-page: 3820 year: 2018 ident: B34 article-title: Nutrient-Dependent Changes of Protein Palmitoylation: impact on Nuclear Enzymes and Regulation of Gene Expression. publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms19123820 – volume: 17 start-page: 518 ident: B9 article-title: Protein Palmitoylation Regulates Cell Survival by Modulating XBP1 Activity in Glioblastoma Multiforme. publication-title: Mol. Ther. Oncolytics doi: 10.1016/j.omto.2020.05.007 – volume: 13 start-page: 17 year: 2020 ident: B31 article-title: Targeted Therapy and Checkpoint Immunotherapy in Lung Cancer. publication-title: Surg. Pathol. Clin. doi: 10.1016/j.path.2019.11.002 – volume: 10 start-page: 1243 year: 2015 ident: B39 article-title: The 2015 World Health Organization Classification of Lung Tumors: impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification. publication-title: J. Thorac. Oncol. doi: 10.1097/JTO.0000000000000630 – volume: 99 start-page: 125 year: 2017 ident: B19 article-title: Cancer Stem Cells in Prostate Cancer: implications for Targeted Therapy. publication-title: Urol. Int. doi: 10.1159/000455160 – volume: 10 start-page: 998 ident: B7 article-title: Activation of JNK and p38 MAPK Mediated by ZDHHC17 Drives Glioblastoma Multiforme Development and Malignant Progression. publication-title: Theranostics doi: 10.7150/thno.40076 – volume: 276 start-page: 31936 year: 2001 ident: B26 article-title: Palmitoylation-dependent control of degradation, life span, and membrane expression of the CCR5 receptor. publication-title: J. Biol. Chem. doi: 10.1074/jbc.M104013200 – volume: 46 start-page: D956 year: 2018 ident: B44 article-title: LinkedOmics: analyzing multi-omics data within and across 32 cancer types. publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkx1090 – volume: 42 start-page: 566 year: 2017 ident: B18 article-title: Dynamic protein acylation: new substrates, mechanisms, and drug targets. publication-title: Trends Biochem. Sci. doi: 10.1016/j.tibs.2017.04.004 – volume: 118 start-page: 919 year: 2018 ident: B14 article-title: Protein lipidation: occurrence, mechanisms, biological functions, and enabling technologies. publication-title: Chem. Rev. doi: 10.1021/acs.chemrev.6b00750 – volume: 77 start-page: 4998 year: 2017 ident: B10 article-title: EZH2 Palmitoylation Mediated by ZDHHC5 in p53-Mutant Glioma Drives Malignant Development and Progression. publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-17-1139 – volume: 8 start-page: 721 year: 2015 ident: B47 article-title: A chromosomal passenger complex protein signature model predicts poor prognosis for non-small-cell lung cancer. publication-title: Onco Targets Ther. doi: 10.2147/OTT.S81328 – volume: 102 start-page: 15545 year: 2005 ident: B35 article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0506580102 – volume: 13 start-page: 1330 year: 2010 ident: B29 article-title: Dynamic epigenetic regulation in neurons: enzymes, stimuli and signaling pathways. publication-title: Nat. Neurosci. doi: 10.1038/nn.2671 – volume: 10 start-page: 565414 year: 2020 ident: B21 article-title: Bioinformatics Analysis of the Prognostic and Biological Significance of ZDHHC-Protein Acyltransferases in Kidney Renal Clear Cell Carcinoma. publication-title: Front. Oncol. doi: 10.3389/fonc.2020.565414 – volume: 19 start-page: e46666 year: 2018 ident: B16 article-title: Protein palmitoylation and cancer. publication-title: EMBO Rep. doi: 10.15252/embr.201846666 – volume: 21 start-page: 4569 year: 2020 ident: B45 article-title: Genetic Markers in Lung Cancer Diagnosis: a Review. publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms21134569 – volume: 38 start-page: 25 year: 2019 ident: B8 article-title: DHHC protein family targets different subsets of glioma stem cells in specific niches. publication-title: J. Exp. Clin. Cancer Res. doi: 10.1186/s13046-019-1033-2 – volume: 110 start-page: 5 year: 2018 ident: B17 article-title: Adenocarcinoma classification: patterns and prognosis. publication-title: Pathologica – volume: 21 start-page: 405 year: 2016 ident: B33 article-title: ONE-CLASS DETECTION OF CELL STATES IN TUMOR SUBTYPES. publication-title: Pac. Symp. Biocomput. doi: 10.1142/9789814749411_0037 – volume: 48 start-page: 812 year: 2018 ident: B36 article-title: The Immune Landscape of Cancer. publication-title: Immunity doi: 10.1016/j.immuni.2018.03.023 – volume: 7 start-page: 85 year: 2006 ident: B43 article-title: Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. publication-title: EMBO Rep. doi: 10.1038/sj.embor.7400562 – volume: 4 start-page: 40 year: 2015 ident: B25 article-title: Cancer stem cell markers in lung cancer. publication-title: Pers. Med. Univ. doi: 10.1016/j.pmu.2015.03.007 |
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| Title | Potential Role of S-Palmitoylation in Cancer Stem Cells of Lung Adenocarcinoma |
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