Astrocytes Protect Human Dopaminergic Neurons from α-Synuclein Accumulation and Propagation

• Published in: The Journal of neuroscience Vol. 40; no. 45; pp. 8618 - 8628
• Main Authors: Tsunemi, Taiji, Ishiguro, Yuta, Yoroisaka, Asako, Valdez, Clarissa, Miyamoto, Kengo, Ishikawa, Keiichi, Saiki, Shinji, Akamatsu, Wado, Hattori, Nobutaka, Krainc, Dimitri
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 04.11.2020
• Subjects: Accumulation; Adult; alpha-Synuclein - biosynthesis; alpha-Synuclein - metabolism; Astrocytes; Astrocytes - physiology; Axons; Bioaccumulation; Coculture Techniques; Dopamine receptors; Dopaminergic Neurons - metabolism; Dopaminergic Neurons - physiology; Exosomes - metabolism; Female; Glial cells; Humans; Induced Pluripotent Stem Cells; Lewy bodies; Lysosomes; Lysosomes - enzymology; Lysosomes - metabolism; Male; Movement disorders; Mutation; Neurodegenerative diseases; Neuroglia - metabolism; Neuronal-glial interactions; Neurons; Parkinson's disease; Parkinsonian Disorders - genetics; Parkinsonian Disorders - metabolism; Pathogenesis; Pathology; Pluripotency; Propagation; Proton-Translocating ATPases - deficiency; Proton-Translocating ATPases - genetics; Proton-Translocating ATPases - metabolism; Synuclein; Synucleinopathies - genetics; Synucleinopathies - metabolism; Parkinson's disease; Kufor–Rakeb syndrome; astrocyte; α-synuclein

The pathologic hallmark of Parkinson's disease is the accumulation of α-synuclein-containing Lewy bodies/neurites almost exclusively in neurons, and rarely in glial cells. However, emerging evidence suggests that glia such as astrocytes play an important role in the development of α-synuclein p...