Astrocytes Protect Human Dopaminergic Neurons from α-Synuclein Accumulation and Propagation - Tsunemi, Taiji; Ishiguro, Yuta; Yoroisaka, Asako; Valdez, Clarissa; Miyamoto, Kengo; Ishikawa, Keiichi; Saiki, Shinji; Akamatsu, Wado; Hattori, Nobutaka; Krainc, Dimitri (The Journal of neuroscience, 2020)
Keywords: Accumulation; Adult; alpha-Synuclein - biosynthesis; alpha-Synuclein - metabolism; Astrocytes; Astrocytes - physiology; Axons; Bioaccumulation; Coculture Techniques; Dopamine receptors; Dopaminergic Neurons - metabolism; Dopaminergic Neurons - physiology; Exosomes - metabolism; Female; Glial cells; Humans; Induced Pluripotent Stem Cells; Lewy bodies; Lysosomes; Lysosomes - enzymology; Lysosomes - metabolism; Male; Movement disorders; Mutation; Neurodegenerative diseases; Neuroglia - metabolism; Neuronal-glial interactions; Neurons; Parkinson's disease; Parkinsonian Disorders - genetics; Parkinsonian Disorders - metabolism; Pathogenesis; Pathology; Pluripotency; Propagation; Proton-Translocating ATPases - deficiency; Proton-Translocating ATPases - genetics; Proton-Translocating ATPases - metabolism; Synuclein; Synucleinopathies - genetics; Synucleinopathies - metabolism; Parkinson's disease; Kufor–Rakeb syndrome; astrocyte; α-synuclein