Polo-like kinase-1 in DNA damage response

Polo-like kinase-1 (Plk1) belongs to a family of serine-threonine kinases and plays a critical role in mitotic progression. Plk1 involves in the initiation of mitosis, centrosome maturation, bipolar spindle formation, and cytokinesis, well-reported as traditional functions of Plk1. In this review, w...

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Published inBMB reports Vol. 47; no. 5; pp. 249 - 255
Main Authors Hyun, Sun-Yi, Hwan, Hyo-In, Jang, Young-Joo
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Society for Biochemistry and Molecular Biology 01.05.2014
생화학분자생물학회
Subjects
Animals
Cell Cycle
Cell Cycle Proteins - metabolism
DNA Damage
DNA Repair
Humans
Mitosis
Polo-Like Kinase 1
Protein Serine-Threonine Kinases - metabolism
Proto-Oncogene Proteins - metabolism
Tumor Suppressor Protein p53 - metabolism
화학
Online AccessGet full text
ISSN1976-6696
1976-670X
DOI10.5483/BMBRep.2014.47.5.061

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Abstract Polo-like kinase-1 (Plk1) belongs to a family of serine-threonine kinases and plays a critical role in mitotic progression. Plk1 involves in the initiation of mitosis, centrosome maturation, bipolar spindle formation, and cytokinesis, well-reported as traditional functions of Plk1. In this review, we discuss the role of Plk1 during DNA damage response beyond the functions in mitotsis. When DNA is damaged in cells under various stress conditions, the checkpoint mechanism is activated to allow cells to have enough time for repair. When damage is repaired, cells progress continuously their division, which is called checkpoint recovery. If damage is too severe to repair, cells undergo apoptotic pathway. If damage is not completely repaired, cells undergo a process called checkpoint adaptation, and resume cell division cycle with damaged DNA. Plk1 targets and regulates many key factors in the process of damage response, and we deal with these subjects in this review.
AbstractList Polo-like kinase-1 (Plk1) belongs to a family of serine-threoninekinases and plays a critical role in mitotic progression. Plk1involves in the initiation of mitosis, centrosome maturation,bipolar spindle formation, and cytokinesis, well-reported astraditional functions of Plk1. In this review, we discuss the roleof Plk1 during DNA damage response beyond the functions inmitotsis. When DNA is damaged in cells under various stressconditions, the checkpoint mechanism is activated to allowcells to have enough time for repair. When damage is repaired,cells progress continuously their division, which is calledcheckpoint recovery. If damage is too severe to repair, cellsundergo apoptotic pathway. If damage is not completelyrepaired, cells undergo a process called checkpoint adaptation,and resume cell division cycle with damaged DNA. Plk1targets and regulates many key factors in the process of damageresponse, and we deal with these subjects in this review. KCI Citation Count: 26
Polo-like kinase-1 (Plk1) belongs to a family of serine-threonine kinases and plays a critical role in mitotic progression. Plk1 involves in the initiation of mitosis, centrosome maturation, bipolar spindle formation, and cytokinesis, well-reported as traditional functions of Plk1. In this review, we discuss the role of Plk1 during DNA damage response beyond the functions in mitotsis. When DNA is damaged in cells under various stress conditions, the checkpoint mechanism is activated to allow cells to have enough time for repair. When damage is repaired, cells progress continuously their division, which is called checkpoint recovery. If damage is too severe to repair, cells undergo apoptotic pathway. If damage is not completely repaired, cells undergo a process called checkpoint adaptation, and resume cell division cycle with damaged DNA. Plk1 targets and regulates many key factors in the process of damage response, and we deal with these subjects in this review.
Polo-like kinase-1 (Plk1) belongs to a family of serine-threonine kinases and plays a critical role in mitotic progression. Plk1 involves in the initiation of mitosis, centrosome maturation, bipolar spindle formation, and cytokinesis, well-reported as traditional functions of Plk1. In this review, we discuss the role of Plk1 during DNA damage response beyond the functions in mitotsis. When DNA is damaged in cells under various stress conditions, the checkpoint mechanism is activated to allow cells to have enough time for repair. When damage is repaired, cells progress continuously their division, which is called checkpoint recovery. If damage is too severe to repair, cells undergo apoptotic pathway. If damage is not completely repaired, cells undergo a process called checkpoint adaptation, and resume cell division cycle with damaged DNA. Plk1 targets and regulates many key factors in the process of damage response, and we deal with these subjects in this review. [BMB Reports 2014; 47(5): 249-255]
Author Jang, Young-Joo
Hwan, Hyo-In
Hyun, Sun-Yi
AuthorAffiliation Department of Nanobiomedical Science & BK21 PLUS Global Research Center for Regenerative Medicine, Dankook University, Cheonan 330-714, Korea
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  surname: Jang
  fullname: Jang, Young-Joo
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Snippet Polo-like kinase-1 (Plk1) belongs to a family of serine-threonine kinases and plays a critical role in mitotic progression. Plk1 involves in the initiation of...
Polo-like kinase-1 (Plk1) belongs to a family of serine-threoninekinases and plays a critical role in mitotic progression. Plk1involves in the initiation of...
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SubjectTerms Animals
Cell Cycle
Cell Cycle Proteins - metabolism
DNA Damage
DNA Repair
Humans
Mitosis
Polo-Like Kinase 1
Protein Serine-Threonine Kinases - metabolism
Proto-Oncogene Proteins - metabolism
Tumor Suppressor Protein p53 - metabolism
화학
Title Polo-like kinase-1 in DNA damage response
URI https://www.ncbi.nlm.nih.gov/pubmed/24667170
https://pubmed.ncbi.nlm.nih.gov/PMC4163859
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