The Emergence of Novel Sequence Type Strains Reveals an Evolutionary Process of Intraspecies Clone Shifting in ICU-Spreading Carbapenem-Resistant Klebsiella pneumoniae

• Published in: Frontiers in microbiology Vol. 12; p. 691406
• Main Authors: Zhao, Dongdong, Shi, Qiucheng, Hu, Dandan, Fang, Li, Mao, Yihan, Lan, Peng, Han, Xinhong, Zhang, Ping, Hu, Huangdu, Wang, Yanfei, Quan, Jingjing, Yu, Yunsong, Jiang, Yan
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 30.08.2021
• Subjects: capsule biosynthesis locus; carbapenem-resistant; intraspecies shifting; Microbiology; recombination; virulence

Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an urgent public health problem worldwide, and its rapid evolution in the clinical environment has been a major concern. A total of 99 CRKP isolates spreading in the intensive care unit (ICU) setting were included and subjected to whole-genome seq...