A meta-analysis of efficacy and safety of S-1 monotherapy or combination therapy as first-line treatment in metastatic colorectal cancer

• Published in: International journal of colorectal disease Vol. 35; no. 8; pp. 1567 - 1574
• Main Authors: Wang, Zhan, Wang, Miao-Miao, Zhou, Wen-Li, Ye, Chen-Yang, Dai, Wei-Ping, Liu, Xin-Ling, Zhang, Gui-Min, Cheng, Guo-Liang, Zang, Yuan-Sheng
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2020; Springer; Springer Nature B.V
• Subjects: Analysis; Cancer; Chemotherapy; Clinical trials; Colorectal cancer; Colorectal carcinoma; Combination therapy; Disease control; Drug therapy; Gastroenterology; Hepatology; Internal Medicine; Leukopenia; Medicine; Medicine & Public Health; Meta-analysis; Metastases; Metastasis; Original Article; Proctology; Statistical analysis; Surgery; Capecitabine; S-1; Colorectal cancer; 5-Fu; Meta-analysis

Purpose To compare the efficacy and safety profile of S-1-based versus non-S-1-based chemotherapy as first-line treatment in mCRC. Methods Relevant randomized controlled trials (RCTs) were obtained from PubMed, Embase, and Ovid databases and the Cochrane library from database set up in May 2018. The...