Observations on thermostable subpopulations of the unconventional agents that cause transmissible degenerative encephalopathies

• Published in: Veterinary microbiology Vol. 64; no. 1; pp. 33 - 38
• Main Authors: Taylor, D.M, Fernie, K, McConnell, I, Steele, P.J
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.11.1998; Elsevier Science
• Subjects: Action of physical and chemical agents; AGENT DE LA TREMBLANTE DU MOUTON; AGENTE DE TEMBLADERA DE LOS OVINOS; Animals; Biological and medical sciences; Brain - immunology; Brain - pathology; CALOR; CHALEUR; Cricetinae; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; ENCEFALOPATIA ESPONGIFORME; ENCEPHALOPATHIE SPONGIFORME; Fundamental and applied biological sciences. Psychology; HEAT; Hot Temperature; Medical sciences; Mesocricetus; Microbiology; Neurology; PRION; PRIONES; PRIONS; Prions - chemistry; PrPSc Proteins - chemistry; PrPSc Proteins - immunology; RESISTANCE A LA TEMPERATURE; RESISTENCIA A LA TEMPERATURA; Scrapie - immunology; Scrapie - pathology; SCRAPIE AGENT; SPONGIFORM ENCEPHALOPATHY; TEMPERATURE RESISTANCE; Thermostability; Transmissible degenerative encephalopathies; Virology; Thermostability; Transmissible degenerative encephalopathies; Scrapie agent; Nervous system diseases; Temperature; Central nervous system disease; Environmental factor; Degenerative disease; Prion; Spongiform encephalopathy; Veterinary; Inactivation; Thermal stability; Cerebral disorder

When scrapie agent is exposed to partially inactivating autoclave cycles, the fraction of infectivity that survives remains thermostable during relatively long periods of autoclaving. This resistant subpopulation can also be differentiated from the main population by its prolonged incubation periods...