Reward anticipation changes corticospinal excitability during task preparation depending on response requirements and time pressure

• Published in: Cortex Vol. 120; pp. 159 - 168
• Main Authors: Bundt, Carsten, Bardi, Lara, Verbruggen, Frederick, Boehler, Carsten N., Brass, Marcel, Notebaert, Wim
• Format: Journal Article
• Language: English
• Published: Italy Elsevier Ltd 01.11.2019; Elsevier
• Subjects: Cognitive science; Corticospinal excitability; Neuroscience; Primary motor cortex; Psychology; Response preparation; Reward; Transcranial magnetic stimulation; Primary motor cortex; Corticospinal excitability; Transcranial magnetic stimulation; Reward; Response preparation
• ISSN: 0010-9452; 1973-8102
• DOI: 10.1016/j.cortex.2019.05.020

The preparation of an action is accompanied by transient corticospinal (CS) excitability changes. Motivation can modulate these changes. Specifically, when a cue indicates that a reward can be obtained, CS excitability initially increases, followed by a pronounced decrease. This dynamic could reflect processes related to reward expectancy, processes related to action preparation, or a combination of both. Here we set up two experiments to dissociate these accounts. A rewarded choice reaction time task was used in which individuals were cued at the beginning of each trial whether or not a response would be required at target onset and whether or not a reward could be obtained. We used single-pulse transcranial magnetic stimulation (spTMS) over the left primary motor cortex (M1) early (shortly after cue onset) or late (shortly before target onset) preceding target onset to examine CS excitability during motivated action preparation. Electromyography (EMG) was obtained from the right first dorsal interosseous (FDI) muscle. In the first experiment, we used a lenient response deadline, whereas a strict response time-out procedure was employed in the second experiment. Reward modulated CS excitability differentially only in the second experiment: CS excitability was highest during reward anticipation for the early stimulation epoch and was reduced for the late stimulation epoch when individuals were required to prepare a response, while CS excitability remained unchanged during non-reward anticipation. Our findings suggest that the reward effect on CS excitability is dependent on the actual implementation of effort to attain reward (i.e., the preparation of an actual action), as well as on temporal requirements (i.e., time pressure) invoked by the task.