NT5E upregulation in head and neck squamous cell carcinoma: A novel biomarker on cancer-associated fibroblasts for predicting immunosuppressive tumor microenvironment

• Published in: Frontiers in immunology Vol. 13; p. 975847
• Main Authors: Chen, Xue-min, Liu, Yu-yang, Tao, Bing-yan, Xue, Xin-miao, Zhang, Xin-xin, Wang, Lin-lin, Zhong, Hui, Zhang, Jun, Yang, Shi-ming, Jiang, Qing-qing
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 26.08.2022
• Subjects: cancer-associated fibroblast; extracellular matrix; head and neck squamous cell carcinoma; Immunology; immunotherapy; NT5E; tumor microenvironment

Despite tremendous progress made in the diagnosis and managements, head and neck squamous cell carcinoma (HNSC) remains a global medical dilemma with dismal clinical prognosis and high mortality. Gene NT5E encodes the ecto-5’-nucleotidase (CD73), which facilitates the formation of immunosuppressive...