Cotranscriptional Association of mRNA Export Factor Yra1 with C-terminal Domain of RNA Polymerase II

• Published in: The Journal of biological chemistry Vol. 286; no. 42; pp. 36385 - 36395
• Main Authors: MacKellar, April L., Greenleaf, Arno L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.10.2011; American Society for Biochemistry and Molecular Biology
• Subjects: Amino Acid Motifs; CTD; CTD Kinase I; Gene Regulation; Hyperphosphorylated; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; PCID; Phospho-CTD Binding; Phosphorylation; Phosphorylation - physiology; Protein Binding; Protein Structure, Tertiary; RNA Polymerase II; RNA Polymerase II - genetics; RNA Polymerase II - metabolism; RNA Transport; RNA, Fungal - biosynthesis; RNA, Fungal - genetics; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; RNA-binding Proteins; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; Transcription; Transcription, Genetic - physiology; Hyperphosphorylated; Phosphorylation; CTD; RNA Transport; Transcription; RNA-binding Proteins; CTD Kinase I; Phospho-CTD Binding; PCID; RNA Polymerase II

The unique C-terminal domain (CTD) of RNA polymerase II, composed of tandem heptad repeats of the consensus sequence YSPTSPS, is subject to differential phosphorylation throughout the transcription cycle. Several RNA processing factors have been shown to bind the phosphorylated CTD and use it to loc...