Clomiphene citrate ‘stair-step’ protocol vs. traditional protocol in patients with polycystic ovary syndrome: a randomized controlled trial

• Published in: Archives of gynecology and obstetrics Vol. 291; no. 1; pp. 179 - 184
• Main Authors: Deveci, Canan Dura, Demir, Berfu, Sengul, Ozlem, Dilbaz, Berna, Goktolga, Umit
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2015; Springer Nature B.V
• Subjects: Adult; Clomiphene - administration & dosage; Clomiphene - adverse effects; Clomiphene - therapeutic use; Endocrinology; Female; Fertility Agents, Female - administration & dosage; Fertility Agents, Female - adverse effects; Fertility Agents, Female - therapeutic use; Gynecologic Endocrinology and Reproductive Medicine; Gynecology; Human Genetics; Humans; Medicine; Medicine & Public Health; Obstetrics/Perinatology/Midwifery; Ovulation; Ovulation Induction - methods; Polycystic ovary syndrome; Polycystic Ovary Syndrome - drug therapy; Pregnancy; Pregnancy Rate; Prospective Studies; Polycystic ovary syndrome; Stair-step protocol; Traditional protocol; Clomiphene citrate

Purpose To evaluate the efficacy of the stair-step protocol using clomiphene citrate (CC) and to assess the uterine and systemic side effects in patients with polycystic ovary syndrome (PCOS). Methods A total of 60 PCOS patients who failed to respond to 50 mg/day for 5 days of CC treatment within th...