Characterisation of canine CD34+/CD45 diminished cells by colony-forming unit assay and transcriptome analysis

• Published in: Frontiers in veterinary science Vol. 9; p. 936623
• Main Authors: Ayabe, Taro, Hisasue, Masaharu, Yamada, Yoko, Nitta, Suguru, Kikuchi, Kaoruko, Neo, Sakurako, Matsumoto, Yuki, Horie, Ryo, Kawamoto, Kosuke
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 12.09.2022
• Subjects: bone marrow; CD34; dog; stem cell; surface antigen; Veterinary Science

Haematopoietic stem and progenitor cells (HSPCs) are used for transplantation to reconstruct the haematopoietic pathways in humans receiving severe chemotherapy. However, the characteristics of canine HSPCs, such as specific surface antigens and gene expression profiles, are still unclear. This stud...