Epigenetic Control of Autophagy Related Genes Transcription in Pulpitis via JMJD3

Autophagy is an intracellular self-cannibalization process delivering cytoplasmic components to lysosomes for digestion. Autophagy has been reported to be involved in pulpitis, but the regulation of autophagy during pulpitis progression is largely unknown. To figure out the epigenetic regulation of...

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Published inFrontiers in cell and developmental biology Vol. 9; p. 654958
Main Authors Yin, Bei, Ma, Qingge, Zhao, Lingyi, Song, Chenghao, Wang, Chenglin, Yu, Fanyuan, Shi, Yu, Ye, Ling
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 09.08.2021
Subjects
autophagy
Cell and Developmental Biology
epigenetics
histone methylation
JMJD3
pulpitis
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Abstract Autophagy is an intracellular self-cannibalization process delivering cytoplasmic components to lysosomes for digestion. Autophagy has been reported to be involved in pulpitis, but the regulation of autophagy during pulpitis progression is largely unknown. To figure out the epigenetic regulation of autophagy during pulpitis, we screened several groups of histone methyltransferases and demethylases in response to TNFα treatment. It was found JMJD3, a histone demethylase reducing di- and tri-methylation of H3K27, regulated the expression of several key autophagy genes via demethylation of H3K27me3 at the gene promoters. Our study highlighted the epigenetic regulation of autophagy genes during pulpitis, which will potentially provide a novel therapeutic strategy.
AbstractList Autophagy is an intracellular self-cannibalization process delivering cytoplasmic components to lysosomes for digestion. Autophagy has been reported to be involved in pulpitis, but the regulation of autophagy during pulpitis progression is largely unknown. To figure out the epigenetic regulation of autophagy during pulpitis, we screened several groups of histone methyltransferases and demethylases in response to TNFα treatment. It was found JMJD3, a histone demethylase reducing di- and tri-methylation of H3K27, regulated the expression of several key autophagy genes via demethylation of H3K27me3 at the gene promoters. Our study highlighted the epigenetic regulation of autophagy genes during pulpitis, which will potentially provide a novel therapeutic strategy.
Author Yu, Fanyuan
Yin, Bei
Ma, Qingge
Zhao, Lingyi
Wang, Chenglin
Song, Chenghao
Ye, Ling
Shi, Yu
AuthorAffiliation 1 State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University , Chengdu , China
2 West China School of Stomatology, Sichuan University , Chengdu , China
AuthorAffiliation_xml – name: 1 State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University , Chengdu , China
– name: 2 West China School of Stomatology, Sichuan University , Chengdu , China
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Edited by: Yujing Li, Emory University, United States
This article was submitted to Epigenomics and Epigenetics, a section of the journal Frontiers in Cell and Developmental Biology
Reviewed by: Sanjay Gupta, Case Western Reserve University, United States; Abhijit Shukla, Memorial Sloan Kettering Cancer Center, United States
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Snippet Autophagy is an intracellular self-cannibalization process delivering cytoplasmic components to lysosomes for digestion. Autophagy has been reported to be...
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StartPage 654958
SubjectTerms autophagy
Cell and Developmental Biology
epigenetics
histone methylation
JMJD3
pulpitis
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Title Epigenetic Control of Autophagy Related Genes Transcription in Pulpitis via JMJD3
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