Early Intraarticular Injection of Hyaluronic Acid Attenuates Osteoarthritis Progression in Anterior Cruciate Ligament-Transected Rats

• Published in: Connective tissue research Vol. 54; no. 1; pp. 49 - 54
• Main Authors: Tsai, Wei-Yuan, Wu, Jia-Lin, Liu, Chih-Chung, Cherng, Chen-Hwan, Tsai, Ru-Yin, Jean, Yen-Hsuan, Wong, Chih-Shung
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.02.2013; Taylor & Francis
• Subjects: Adjuvants, Immunologic - administration & dosage; Amino Acid Transport System y+ - genetics; Amino Acid Transport System y+ - metabolism; Animals; Anterior Cruciate Ligament - pathology; Anterior Cruciate Ligament Injuries; anterior cruciate ligament transaction; Cartilage, Articular - injuries; Cartilage, Articular - pathology; cystine/glutamate antiporter system; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Gene Expression Regulation; hyaluronic acid; Hyaluronic Acid - administration & dosage; Injections, Intra-Articular; Male; osteoarthritis; Osteoarthritis, Knee - diagnosis; Osteoarthritis, Knee - prevention & control; prophylaxis; Rats; Rats, Wistar; Stifle - injuries; Stifle - pathology; Time Factors

Subject: Hyaluronic acid (HA) is widely used to relieve the symptoms of osteoarthritis (OA). An association of reduction of glutamate content with the synovial fluid of OA rats was reported previously. Design: Anterior cruciate ligament transaction (ACLT) was performed on one knee in male Wistar rat...