Intracellular calcium stores and agonist-induced contractions in isolated human myometrium
Objective: We hypothesized that the release of calcium from intracellular stores contributes to the contractions produced by the agonists oxytocin, carbachol, and prostaglandin F 2 α in human myometrium. Study Design: Strips of myometrium were obtained at cesarean section and hysterectomy. The strip...
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Published in | American journal of obstetrics and gynecology Vol. 181; no. 2; pp. 468 - 476 |
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Main Authors | , , |
Format | Journal Article Conference Proceeding |
Language | English |
Published |
Philadelphia, PA
Mosby, Inc
01.08.1999
Elsevier |
Subjects | |
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Abstract | Objective: We hypothesized that the release of calcium from intracellular stores contributes to the contractions produced by the agonists oxytocin, carbachol, and prostaglandin F
2
α in human myometrium.
Study Design: Strips of myometrium were obtained at cesarean section and hysterectomy. The strips were loaded with the calcium-sensitive dye Indo-1 to enable simultaneous measurement of tension and intracellular calcium levels. Agonist-induced responses in the presence and absence of extracellular calcium were studied.
Results: Strips of myometrium were obtained from 48 women not in labor undergoing cesarean section and 6 women not pregnant undergoing hysterectomy. An increase in intracellular calcium level after agonist stimulation invariably preceded an increase in tension. Intracellular calcium level returned to baseline before myometrial relaxation. Oxytocin, carbachol, and prostaglandin F
2
α all gave both force and intracellular calcium responses in the absence of extracellular calcium, although both these responses were only 26% to 40% of the maximal response when extracellular calcium was present.
Conclusions: Release of calcium from internal stores induced by oxytocin, carbachol, and prostaglandin F
2
α may contribute to agonist-induced myometrial force production. (Am J Obstet Gynecol 1999;181:468-76.) |
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AbstractList | Objective: We hypothesized that the release of calcium from intracellular stores contributes to the contractions produced by the agonists oxytocin, carbachol, and prostaglandin F
2
α in human myometrium.
Study Design: Strips of myometrium were obtained at cesarean section and hysterectomy. The strips were loaded with the calcium-sensitive dye Indo-1 to enable simultaneous measurement of tension and intracellular calcium levels. Agonist-induced responses in the presence and absence of extracellular calcium were studied.
Results: Strips of myometrium were obtained from 48 women not in labor undergoing cesarean section and 6 women not pregnant undergoing hysterectomy. An increase in intracellular calcium level after agonist stimulation invariably preceded an increase in tension. Intracellular calcium level returned to baseline before myometrial relaxation. Oxytocin, carbachol, and prostaglandin F
2
α all gave both force and intracellular calcium responses in the absence of extracellular calcium, although both these responses were only 26% to 40% of the maximal response when extracellular calcium was present.
Conclusions: Release of calcium from internal stores induced by oxytocin, carbachol, and prostaglandin F
2
α may contribute to agonist-induced myometrial force production. (Am J Obstet Gynecol 1999;181:468-76.) OBJECTIVEWe hypothesized that the release of calcium from intracellular stores contributes to the contractions produced by the agonists oxytocin, carbachol, and prostaglandin F(2 )(alpha ) in human myometrium.STUDY DESIGNStrips of myometrium were obtained at cesarean section and hysterectomy. The strips were loaded with the calcium-sensitive dye Indo-1 to enable simultaneous measurement of tension and intracellular calcium levels. Agonist-induced responses in the presence and absence of extracellular calcium were studied.RESULTSStrips of myometrium were obtained from 48 women not in labor undergoing cesarean section and 6 women not pregnant undergoing hysterectomy. An increase in intracellular calcium level after agonist stimulation invariably preceded an increase in tension. Intracellular calcium level returned to baseline before myometrial relaxation. Oxytocin, carbachol, and prostaglandin F(2)(alpha) all gave both force and intracellular calcium responses in the absence of extracellular calcium, although both these responses were only 26% to 40% of the maximal response when extracellular calcium was present.CONCLUSIONSRelease of calcium from internal stores induced by oxytocin, carbachol, and prostaglandin F(2)(alpha) may contribute to agonist-induced myometrial force production. We hypothesized that the release of calcium from intracellular stores contributes to the contractions produced by the agonists oxytocin, carbachol, and prostaglandin F(2 )(alpha ) in human myometrium. Strips of myometrium were obtained at cesarean section and hysterectomy. The strips were loaded with the calcium-sensitive dye Indo-1 to enable simultaneous measurement of tension and intracellular calcium levels. Agonist-induced responses in the presence and absence of extracellular calcium were studied. Strips of myometrium were obtained from 48 women not in labor undergoing cesarean section and 6 women not pregnant undergoing hysterectomy. An increase in intracellular calcium level after agonist stimulation invariably preceded an increase in tension. Intracellular calcium level returned to baseline before myometrial relaxation. Oxytocin, carbachol, and prostaglandin F(2)(alpha) all gave both force and intracellular calcium responses in the absence of extracellular calcium, although both these responses were only 26% to 40% of the maximal response when extracellular calcium was present. Release of calcium from internal stores induced by oxytocin, carbachol, and prostaglandin F(2)(alpha) may contribute to agonist-induced myometrial force production. |
Author | Luckas, Murray J.M. Wray, Susan Taggart, Michael J. |
Author_xml | – sequence: 1 givenname: Murray J.M. surname: Luckas fullname: Luckas, Murray J.M. – sequence: 2 givenname: Michael J. surname: Taggart fullname: Taggart, Michael J. – sequence: 3 givenname: Susan surname: Wray fullname: Wray, Susan |
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Keywords | myometrium Agonist calcium sarcoplasmic reticulum Human Myometrium Calcium Arachidonic acid derivatives Oxytocic Inductor In vitro Contraction Prostaglandin F2α Chemotherapy Carbachol Female Influence Oxytocin(drug) Intracellular Release |
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Snippet | Objective: We hypothesized that the release of calcium from intracellular stores contributes to the contractions produced by the agonists oxytocin, carbachol,... We hypothesized that the release of calcium from intracellular stores contributes to the contractions produced by the agonists oxytocin, carbachol, and... OBJECTIVEWe hypothesized that the release of calcium from intracellular stores contributes to the contractions produced by the agonists oxytocin, carbachol,... |
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SubjectTerms | Adult Agonist Biological and medical sciences calcium Calcium - analysis Calcium - metabolism Carbachol - pharmacology Dinoprost - pharmacology Female Genital system. Reproduction Humans Intracellular Fluid - metabolism Medical sciences myometrium Myometrium - drug effects Myometrium - physiology Oxytocin - pharmacology Pharmacology. Drug treatments Potassium - administration & dosage Potassium - pharmacology Pregnancy sarcoplasmic reticulum Uterine Contraction - drug effects |
Title | Intracellular calcium stores and agonist-induced contractions in isolated human myometrium |
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