Family 1 glycosyltransferases (GT1, UGTs) are subject to dilution-induced inactivation and low chemo stability toward their own acceptor substrates

• Published in: Frontiers in molecular biosciences Vol. 9; p. 909659
• Main Authors: Teze, David, Bidart, Gonzalo Nahuel, Welner, Ditte Hededam
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 22.07.2022
• Subjects: biotechnology; glycosylation; glycosyltransferases; GT1; Molecular Biosciences; polyphenols; stability

Glycosylation reactions are essential but challenging from a conventional chemistry standpoint. Conversely, they are biotechnologically feasible as glycosyltransferases can transfer sugar to an acceptor with perfect regio- and stereo-selectivity, quantitative yields, in a single reaction and under m...