Simultaneous detection of genomic imbalance in patients receiving preimplantation genetic testing for monogenic diseases (PGT-M)

• Published in: Frontiers in genetics Vol. 13; p. 976131
• Main Authors: Yang, Lin, Xu, Yan, Xia, Jun, Yan, Huijuan, Ding, Chenhui, Shi, Qianyu, Wu, Yujing, Liu, Ping, Pan, Jiafu, Zeng, Yanhong, Zhang, Yanyan, Chen, Fang, Jiang, Hui, Xu, Yanwen, Li, Wei, Zhou, Canquan, Gao, Ya
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 29.09.2022
• Subjects: chromosome abnormality; Genetics; IVF; monogenic disease; PGT-A/M; TAGs-seq

Background: Preimplantation genetic test for monogenic disorders (PGT-M) has been used to select genetic disease-free embryos for implantation during in vitro fertilization (IVF) treatment. However, embryos tested by PGT-M have risks of harboring chromosomal aneuploidy. Hence, a universal method to...