Effects of ilaprazole on the steady-state pharmacodynamics of clopidogrel in healthy volunteers: An open-label randomized crossover study

• Published in: Frontiers in pharmacology Vol. 13; p. 952804
• Main Authors: Ye, Zekang, Chen, Pengsheng, Tan, Chuchu, Gong, Xiaoxuan, Li, Ran, Dong, Zhou, Ullah, Inam, Zhou, Chen, Zhou, Sufeng, Xie, Lijun, Hou, Xuemei, Han, Zhihui, Gu, Qian, Ma, Jiazheng, Teng, Jianzhen, Tang, Yingdan, Zhang, Zhuanxia, Hu, Haitang, Zhuang, Quankun, Chen, Juan, Zhu, Bei, Shao, Feng, Li, Chunjian
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 08.09.2022
• Subjects: clopidogrel; drug-drug interaction; ilaprazole; maximal platelet aggregation; Pharmacology; platelet reactivity index

Background: Previous studies have suggested that proton pump inhibitors could impair the antiplatelet effect of clopidogrel. It is uncertain whether ilaprazole affects the antiplatelet effect of clopidogrel. This study aimed to determine the drug-drug interaction between ilaprazole and clopidogrel....