Posterior Parietal Cortex Dysfunction Is Central to Working Memory Storage and Broad Cognitive Deficits in Schizophrenia

• Published in: The Journal of neuroscience Vol. 38; no. 39; pp. 8378 - 8387
• Main Authors: Hahn, Britta, Robinson, Benjamin M., Leonard, Carly J., Luck, Steven J., Gold, James M.
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 26.09.2018
• Subjects: Brain; Brain mapping; Change detection; Cognitive ability; Cortex (parietal); Functional magnetic resonance imaging; Intraparietal sulcus; Medical imaging; Mental disorders; Neuroimaging; Neurology; Partially stabilized zirconia; Schizophrenia; Short term memory; Storage; Storage capacity; Zirconium dioxide; fMRI; schizophrenia; cognition; posterior parietal cortex; working memory

PFC dysfunction is widely believed to underlie working memory (WM) deficits in people with schizophrenia (PSZ), but few studies have focused on measures of WM storage devoid of manipulation. Research in neurotypical individuals has shown that storage capacity is more closely related to posterior par...