Function and dysfunction of leucine-rich repeat kinase 2 (LRRK2): Parkinson's disease and beyond

• Published in: BMB reports Vol. 48; no. 5; pp. 243 - 248
• Main Authors: Bae, Jae Ryul, Lee, Byoung Dae
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Society for Biochemistry and Molecular Biology 01.05.2015; 생화학분자생물학회
• Subjects: Alzheimer Disease - physiopathology; Humans; Inflammatory Bowel Diseases - physiopathology; Invited Mini Review; Leprosy - physiopathology; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Neoplasms - physiopathology; Parkinson Disease - physiopathology; Protein-Serine-Threonine Kinases - physiology; 화학

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease (PD). As such, functions and dysfunctions of LRRK2 in PD have been the subject of extensive investigation. In addition to PD, increasing evidence is suggesting that LRRK2 is associated wi...