Sweet but sour: Impaired attention functioning in children with type 1 diabetes mellitus

Children diagnosed with type 1 diabetes mellitus (T1DM) are at risk for neurocognitive sequelae, including impaired attention functioning. The specific nature of the cognitive deficit varies; current literature underscores early age of diabetes diagnosis and increased disease duration as primary ris...

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Published inFrontiers in human neuroscience Vol. 16; p. 895835
Main Authors Lancrei, Hayley M., Yeshayahu, Yonatan, Grossman, Ephraim S., Berger, Itai
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 08.09.2022
Subjects
ADHD
brain development
complications
diabetes mellitus
Neuroscience
pediatrics
type 1
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Abstract Children diagnosed with type 1 diabetes mellitus (T1DM) are at risk for neurocognitive sequelae, including impaired attention functioning. The specific nature of the cognitive deficit varies; current literature underscores early age of diabetes diagnosis and increased disease duration as primary risk factors for this neurocognitive decline. Forty-three children with T1DM were evaluated for Attention Deficit/Hyperactivity Disorder (ADHD) symptomatology using the MOXO continuous performance test (MOXO-CPT) performed during a routine outpatient evaluation. The study cohort demonstrated a significant decline in all four domains of attention functioning. The effect was most pronounced with early age at T1DM diagnosis, a longer disease duration and with poorer glycemic control (represented by higher HbA1c values). With increased disease duration (of 5 plus years), acute hyperglycemia was associated with inattention in the real-time setting. These findings highlight the need for routine screening of neurocognitive function in children with T1DM so that early intervention can be employed during this crucial period of cognitive development.
AbstractList Children diagnosed with type 1 diabetes mellitus (T1DM) are at risk for neurocognitive sequelae, including impaired attention functioning. The specific nature of the cognitive deficit varies; current literature underscores early age of diabetes diagnosis and increased disease duration as primary risk factors for this neurocognitive decline. Forty-three children with T1DM were evaluated for Attention Deficit/Hyperactivity Disorder (ADHD) symptomatology using the MOXO continuous performance test (MOXO-CPT) performed during a routine outpatient evaluation. The study cohort demonstrated a significant decline in all four domains of attention functioning. The effect was most pronounced with early age at T1DM diagnosis, a longer disease duration and with poorer glycemic control (represented by higher HbA1c values). With increased disease duration (of 5 plus years), acute hyperglycemia was associated with inattention in the real-time setting. These findings highlight the need for routine screening of neurocognitive function in children with T1DM so that early intervention can be employed during this crucial period of cognitive development.
Author Yeshayahu, Yonatan
Berger, Itai
Lancrei, Hayley M.
Grossman, Ephraim S.
AuthorAffiliation 5 Pediatric Neurology Clinic, Samson Assuta-Ashdod University Hospital , Ashdod , Israel
4 Department of Education, Ariel University , Ariel , Israel
3 Pediatric Endocrinology Clinic, Samson Assuta-Ashdod University Hospital , Ashdod , Israel
2 Faculty of Health Sciences, Ben-Gurion University of the Negev , Be’er Sheva , Israel
1 Department of Pediatrics, Samson Assuta-Ashdod University Hospital , Ashdod , Israel
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Edited by: Ronny Geva, Bar-Ilan University, Israel
These authors have contributed equally to this work and share first authorship
Reviewed by: Stephen R. Hooper, University of North Carolina at Chapel Hill, United States; Lara Catherine Foland-Ross, Stanford University, United States
This article was submitted to Brain Health and Clinical Neuroscience, a section of the journal Frontiers in Human Neuroscience
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SubjectTerms ADHD
brain development
complications
diabetes mellitus
Neuroscience
pediatrics
type 1
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Title Sweet but sour: Impaired attention functioning in children with type 1 diabetes mellitus
URI https://search.proquest.com/docview/2718642772
https://pubmed.ncbi.nlm.nih.gov/PMC9495930
https://doaj.org/article/2ad345e3e2094a3b988f54028129569d
Volume 16
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