Influenza A(H1N1)pdm09 Virus with Reduced Susceptibility to Baloxavir, Japan, 2024
Influenza A(H1N1)pdm09 virus carrying an I38N substitution was detected in an untreated teenager in Japan. The I38N mutant virus exhibited reduced susceptibility to baloxavir but remained susceptible to neuraminidase inhibitors and showed reduced growth capability. Monitoring antiviral drug suscepti...
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| Published in | Emerging infectious diseases Vol. 31; no. 5; pp. 1019 - 1022 |
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| Main Authors | , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Centers for Disease Control and Prevention
01.05.2025
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| Subjects | |
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| Abstract | Influenza A(H1N1)pdm09 virus carrying an I38N substitution was detected in an untreated teenager in Japan. The I38N mutant virus exhibited reduced susceptibility to baloxavir but remained susceptible to neuraminidase inhibitors and showed reduced growth capability. Monitoring antiviral drug susceptibility of influenza viruses is necessary to aid public health planning and clinical recommendations. |
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| AbstractList | Influenza A(H1N1)pdm09 virus carrying an I38N substitution was detected in an untreated teenager in Japan. The I38N mutant virus exhibited reduced susceptibility to baloxavir but remained susceptible to neuraminidase inhibitors and showed reduced growth capability. Monitoring antiviral drug susceptibility of influenza viruses is necessary to aid public health planning and clinical recommendations. Influenza A(H1N1)pdm09 virus carrying an I38N substitution was detected in an untreated teenager in Japan. The I38N mutant virus exhibited reduced susceptibility to baloxavir but remained susceptible to neuraminidase inhibitors and showed reduced growth capability. Monitoring antiviral drug susceptibility of influenza viruses is necessary to aid public health planning and clinical recommendations.Influenza A(H1N1)pdm09 virus carrying an I38N substitution was detected in an untreated teenager in Japan. The I38N mutant virus exhibited reduced susceptibility to baloxavir but remained susceptible to neuraminidase inhibitors and showed reduced growth capability. Monitoring antiviral drug susceptibility of influenza viruses is necessary to aid public health planning and clinical recommendations. |
| Author | Ogawa, Naomi Takashita, Emi Ito, Sueshi Shirakura, Masayuki Morita, Hiroko Komabayashi, Kenichi Watanabe, Shinji Miura, Hideka Ikeda, Tatsuya Matoba, Yohei Fujisaki, Seiichiro Mizuta, Katsumi Nakamura, Kazuya Sasaki, Mika Nagata, Shiho Kishida, Noriko Takahashi, Tomoko Hasegawa, Hideki |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40180581$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.antiviral.2021.105158 10.1016/j.antiviral.2022.105281 10.1101/cshperspect.a038687 10.1093/infdis/jis337 10.1111/irv.12821 10.1038/s41598-018-27890-4 10.3201/eid2511.190757 10.1038/s41564-019-0609-0 10.2807/1560-7917.ES.2019.24.12.1900170 10.3389/fmicb.2018.03026 10.1128/AAC.04836-14 10.1093/infdis/jiaa164 10.2807/1560-7917.ES.2023.28.39.2300501 |
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| Keywords | influenza viruses polymerase acidic protein Japan I38N substitution respiratory infections baloxavir marboxil antimicrobial resistance influenza virus A(H1N1)pdm09 cap-dependent endonuclease inhibitor drug resistance baloxavir acid |
| Language | English |
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| Title | Influenza A(H1N1)pdm09 Virus with Reduced Susceptibility to Baloxavir, Japan, 2024 |
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