Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration

Adult stem cells that are tightly regulated by the specific microenvironment, or the stem cell niche, function to maintain tissue homeostasis and regeneration after damage. This demands the existence of specific niche components that can preserve the stem cell pool in injured tissues and restore the...

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Published inFrontiers in cell and developmental biology Vol. 8; p. 576176
Main Authors Sagaradze, Georgy D., Basalova, Nataliya A., Efimenko, Anastasia Yu, Tkachuk, Vsevolod A.
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 25.09.2020
Subjects
adult stem cells
aging
Cell and Developmental Biology
mesenchymal stromal cells (MSC)
regenerative medicine
stem cell niche
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Abstract Adult stem cells that are tightly regulated by the specific microenvironment, or the stem cell niche, function to maintain tissue homeostasis and regeneration after damage. This demands the existence of specific niche components that can preserve the stem cell pool in injured tissues and restore the microenvironment for their subsequent appropriate functioning. This role may belong to mesenchymal stromal cells (MSCs) due to their resistance to damage signals and potency to be specifically activated in response to tissue injury and promote regeneration by different mechanisms. Increased amount of data indicate that activated MSCs are able to produce factors such as extracellular matrix components, growth factors, extracellular vesicles and organelles, which transiently substitute the regulatory signals from missing niche cells and restrict the injury-induced responses of them. MSCs may recruit functional cells into a niche or differentiate into missing cell components to endow a niche with ability to regulate stem cell fates. They may also promote the dedifferentiation of committed cells to re-establish a pool of functional stem cells after injury. Accumulated evidence indicates the therapeutic promise of MSCs for stimulating tissue regeneration, but the benefits of administered MSCs demonstrated in many injury models are less than expected in clinical studies. This emphasizes the importance of considering the mechanisms of endogenous MSC functioning for the development of effective approaches to their pharmacological activation or mimicking their effects. To achieve this goal, we integrate the current ideas on the contribution of MSCs in restoring the stem cell niches after damage and thereby tissue regeneration.
AbstractList Adult stem cells that are tightly regulated by the specific microenvironment, or the stem cell niche, function to maintain tissue homeostasis and regeneration after damage. This demands the existence of specific niche components that can preserve the stem cell pool in injured tissues and restore the microenvironment for their subsequent appropriate functioning. This role may belong to mesenchymal stromal cells (MSCs) due to their resistance to damage signals and potency to be specifically activated in response to tissue injury and promote regeneration by different mechanisms. Increased amount of data indicate that activated MSCs are able to produce factors such as extracellular matrix components, growth factors, extracellular vesicles and organelles, which transiently substitute the regulatory signals from missing niche cells and restrict the injury-induced responses of them. MSCs may recruit functional cells into a niche or differentiate into missing cell components to endow a niche with ability to regulate stem cell fates. They may also promote the dedifferentiation of committed cells to re-establish a pool of functional stem cells after injury. Accumulated evidence indicates the therapeutic promise of MSCs for stimulating tissue regeneration, but the benefits of administered MSCs demonstrated in many injury models are less than expected in clinical studies. This emphasizes the importance of considering the mechanisms of endogenous MSC functioning for the development of effective approaches to their pharmacological activation or mimicking their effects. To achieve this goal, we integrate the current ideas on the contribution of MSCs in restoring the stem cell niches after damage and thereby tissue regeneration.
Author Tkachuk, Vsevolod A.
Basalova, Nataliya A.
Efimenko, Anastasia Yu
Sagaradze, Georgy D.
AuthorAffiliation 2 Faculty of Medicine, Lomonosov Moscow State University , Moscow , Russia
1 Institute for Regenerative Medicine, Medical Research and Education Center, Lomonosov Moscow State University , Moscow , Russia
AuthorAffiliation_xml – name: 1 Institute for Regenerative Medicine, Medical Research and Education Center, Lomonosov Moscow State University , Moscow , Russia
– name: 2 Faculty of Medicine, Lomonosov Moscow State University , Moscow , Russia
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  givenname: Anastasia Yu
  surname: Efimenko
  fullname: Efimenko, Anastasia Yu
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  givenname: Vsevolod A.
  surname: Tkachuk
  fullname: Tkachuk, Vsevolod A.
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Snippet Adult stem cells that are tightly regulated by the specific microenvironment, or the stem cell niche, function to maintain tissue homeostasis and regeneration...
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SubjectTerms adult stem cells
aging
Cell and Developmental Biology
mesenchymal stromal cells (MSC)
regenerative medicine
stem cell niche
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Title Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration
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