Circadian Rhythm Disruption Aggravates DSS-Induced Colitis in Mice with Fecal Calprotectin as a Marker of Colitis Severity

• Published in: Digestive diseases and sciences Vol. 64; no. 11; pp. 3122 - 3133
• Main Authors: Amara, Joseph, Saliba, Youakim, Hajal, Joelle, Smayra, Viviane, Bakhos, Jules-Joel, Sayegh, Raymond, Fares, Nassim
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.11.2019; Springer; Springer Nature B.V
• Subjects: Animals; Biochemistry; Biomarkers - chemistry; Biomarkers - metabolism; Circadian rhythm; Circadian Rhythm - physiology; Colitis; Colitis - chemically induced; Colitis - metabolism; Colitis - pathology; Colon; Cytokines; Dextran; Dextran Sulfate - toxicity; Ethylenediaminetetraacetic acid; Feces; Feces - chemistry; Gastroenterology; Gastrointestinal diseases; Hepatology; Inflammation; Inflammatory bowel disease; Leukocyte L1 Antigen Complex - analysis; Leukocyte L1 Antigen Complex - metabolism; Male; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Mice; Mice, Inbred C57BL; Oncology; Original Article; Permeability; Risk factors; Severity of Illness Index; Sulfates; Transplant Surgery; Fecal calprotectin; DSS-induced colitis; Inflammation; Circadian rhythm

Background Inflammatory bowel disease (IBD) is a chronic immunologically mediated pathology that remains a major health burden. Circadian rhythm disruption leads to a deregulation in the immune system which is a major risk factor for IBD. Aims Since fecal calprotectin (FC) has been a useful tool for...