Association of the Endosomal Sorting Complex ESCRT-II with the Vps20 Subunit of ESCRT-III Generates a Curvature-sensitive Complex Capable of Nucleating ESCRT-III Filaments

• Published in: The Journal of biological chemistry Vol. 286; no. 39; pp. 34262 - 34270
• Main Authors: Fyfe, Ian, Schuh, Amber L., Edwardson, J. Michael, Audhya, Anjon
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 30.09.2011; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Atomic Force Microscopy; Caenorhabditis elegans - chemistry; Caenorhabditis elegans - genetics; Caenorhabditis elegans - metabolism; Caenorhabditis elegans Proteins - chemistry; Caenorhabditis elegans Proteins - genetics; Caenorhabditis elegans Proteins - metabolism; Cell Membrane - chemistry; Cell Membrane - genetics; Cell Membrane - metabolism; Endosomal Sorting Complexes Required for Transport - chemistry; Endosomal Sorting Complexes Required for Transport - genetics; Endosomal Sorting Complexes Required for Transport - metabolism; Endosomes; ESCRT; Lipid Bilayers - chemistry; Liposomes - chemistry; Membrane Biology; Membrane Curvature; Membrane Fusion; Membrane Trafficking; Protein Structure; Membrane Trafficking; Membrane Fusion; ESCRT; Membrane Curvature; Atomic Force Microscopy; Protein Structure; Endosomes

The scission of membranes necessary for vesicle biogenesis and cytokinesis is mediated by cytoplasmic proteins, which include members of the ESCRT (endosomal sorting complex required for transport) machinery. During the formation of intralumenal vesicles that bud into multivesicular endosomes, the E...