Single-cell transcriptome analysis of the in vivo response to viral infection in the cave nectar bat Eonycteris spelaea

• Published in: Immunity (Cambridge, Mass.) Vol. 55; no. 11; pp. 2187 - 2205.e5
• Main Authors: Gamage, Akshamal M., Chan, Wharton O.Y., Zhu, Feng, Lim, Yan Ting, Long, Sandy, Ahn, Matae, Tan, Chee Wah, Hiang Foo, Randy Jee, Sia, Wan Rong, Lim, Xiao Fang, He, Haopeng, Zhai, Weiwei, Anderson, Danielle E., Sobota, Radoslaw Mikolaj, Dutertre, Charles-Antoine, Wang, Lin-Fa
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 08.11.2022; Elsevier
• Subjects: Animals; Bats; Chiroptera; Chiroptera - genetics; comparative immunology; disease tolerance; Gene Expression Profiling; Life Sciences; Plant Nectar; respiratory infection; Single-Cell Analysis; single-cell transcriptome sequencing; Transcriptome; viral infection; Virus Diseases; Bats; viral infection; disease tolerance; respiratory infection; single-cell transcriptome sequencing; Chiroptera; comparative immunology

Bats are reservoir hosts of many zoonotic viruses with pandemic potential. We utilized single-cell transcriptome sequencing (scRNA-seq) to analyze the immune response in bat lungs upon in vivo infection with a double-stranded RNA virus, Pteropine orthoreovirus PRV3M. Bat neutrophils were distinguish...