Cell-Mediated Immunity to Target the Persistent Human Immunodeficiency Virus Reservoir

• Published in: The Journal of infectious diseases Vol. 215; no. suppl_3; pp. S160 - S171
• Main Authors: Riley, James L., Montaner, Luis J.
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 15.03.2017
• Subjects: Clinical Trials as Topic; HIV - immunology; HIV Infections - immunology; HIV Infections - therapy; HIV Infections - virology; Humans; Immunity, Cellular; Immunotherapy - methods; Supplement; IFN-α; Gene therapy; CCR5; CAR; NK

Effective clearance of virally infected cells requires the sequential activity of innate and adaptive immunity effectors. In human immunodeficiency virus (HIV) infection, naturally induced cell-mediated immune responses rarely eradicate infection. However, optimized immune responses could potentiall...