Transformation of amnion epithelium into skin and hair follicles

• Published in: Differentiation (London) Vol. 72; no. 9; pp. 558 - 565
• Main Authors: Fliniaux, Ingrid, Viallet, Jean P., Dhouailly, Danielle, Jahoda, Colin A.B.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Elsevier B.V 01.12.2004; Blackwell Publishing
• Subjects: amnion; Amnion - cytology; Animals; Carrier Proteins; Cell Differentiation; CHO Cells; Cricetinae; Cricetulus; dermis; Dermis - cytology; Dermis - metabolism; Embryonic Induction; epidermis; Epidermis - cytology; Epidermis - metabolism; epithelial stem cells; Epithelium - embryology; Epithelium - metabolism; Female; hair follicle; Hair Follicle - embryology; Hair Follicle - metabolism; Hedgehog Proteins; Immunohistochemistry; Mice; Mice, Nude; mouse; Noggin; plasticity; Pregnancy; Proteins - physiology; Shh; Skin - embryology; Skin - metabolism; skin replacement; somatopleure; Trans-Activators - physiology; Noggin; mouse; Shh; hair follicle; plasticity; skin replacement; somatopleure; epithelial stem cells; amnion; dermis; epidermis

There is increasing interest into the extent to which epithelial differentiation can be altered by mesenchymal influence, and the molecular basis for these changes. In this study, we investigated whether amnion epithelium could be transformed into skin and hair follicles by associating E12.5 to E14....