TCRβ repertoire of CD4+ and CD8+ T cells is distinct in richness, distribution, and CDR3 amino acid composition

• Published in: Journal of leukocyte biology Vol. 99; no. 3; pp. 505 - 513
• Main Authors: Li, Hoi Ming, Hiroi, Toyoko, Zhang, Yongqing, Shi, Alvin, Chen, Guobing, De, Supriyo, Metter, E. Jeffrey, Wood, William H., Sharov, Alexei, Milner, Joshua D., Becker, Kevin G., Zhan, Ming, Weng, Nan‐ping
• Format: Journal Article
• Language: English
• Published: England Society for Leukocyte Biology 01.03.2016
• Subjects: Adult; Aged; Amino Acids - analysis; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - immunology; Complementarity Determining Regions - analysis; Genes, T-Cell Receptor beta; Human; Humans; Middle Aged; RACE; Receptors, Antigen, T-Cell, alpha-beta - analysis; Receptors, Antigen, T-Cell, alpha-beta - chemistry; RNAseq; supervised learning; Systems Biology & Immunogenetics; TCR diversity; Human; TCR diversity; RNAseq; supervised learning; RACE

Distinct features of TCRβ repertoire present between CD4+ and CD8+ T cells could be used to evaluate the competency of the T cell immunity. The TCR repertoire serves as a reservoir of TCRs for recognizing all potential pathogens. Two major types of T cells, CD4+ and CD8+, that use the same genetic e...