Dual-stimuli-responsive polymer-coated mesoporous silica nanoparticles used for controlled drug delivery
ABSTRACT In this article, a temperature‐ and pH‐responsive delivery system based on block‐copolymer‐capped mesoporous silica nanoparticles (MSNs) is presented. A poly[2‐(diethylamino)ethyl methacrylate)] (PDEAEMA)‐b‐poly(N‐isopropyl acrylamide) (PNIPAM) shell on MSNs was obtained through the surface...
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| Published in | Journal of applied polymer science Vol. 132; no. 32 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken
Blackwell Publishing Ltd
20.08.2015
Wiley Subscription Services, Inc |
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| Abstract | ABSTRACT
In this article, a temperature‐ and pH‐responsive delivery system based on block‐copolymer‐capped mesoporous silica nanoparticles (MSNs) is presented. A poly[2‐(diethylamino)ethyl methacrylate)] (PDEAEMA)‐b‐poly(N‐isopropyl acrylamide) (PNIPAM) shell on MSNs was obtained through the surface‐initiated atom transfer radical polymerization. The block copolymer PDEAEMA‐b‐PNIPAM showed both temperature‐ and pH‐responsive properties. The release of the loaded model molecules from PDEAEMA‐b‐PNIPAM‐coated MSNs could be controlled by changes in the temperature or pH value of the medium. The as‐desired drug‐delivery carrier may be applied to biological systems in the future. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42395. |
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| AbstractList | ABSTRACT
In this article, a temperature‐ and pH‐responsive delivery system based on block‐copolymer‐capped mesoporous silica nanoparticles (MSNs) is presented. A poly[2‐(diethylamino)ethyl methacrylate)] (PDEAEMA)‐b‐poly(N‐isopropyl acrylamide) (PNIPAM) shell on MSNs was obtained through the surface‐initiated atom transfer radical polymerization. The block copolymer PDEAEMA‐b‐PNIPAM showed both temperature‐ and pH‐responsive properties. The release of the loaded model molecules from PDEAEMA‐b‐PNIPAM‐coated MSNs could be controlled by changes in the temperature or pH value of the medium. The as‐desired drug‐delivery carrier may be applied to biological systems in the future. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42395. In this article, a temperature- and pH-responsive delivery system based on block-copolymer-capped mesoporous silica nanoparticles (MSNs) is presented. A poly[2-(diethylamino)ethyl methacrylate)] (PDEAEMA)-b-poly(N-isopropyl acrylamide) (PNIPAM) shell on MSNs was obtained through the surface-initiated atom transfer radical polymerization. The block copolymer PDEAEMA-b-PNIPAM showed both temperature- and pH-responsive properties. The release of the loaded model molecules from PDEAEMA-b-PNIPAM-coated MSNs could be controlled by changes in the temperature or pH value of the medium. The as-desired drug-delivery carrier may be applied to biological systems in the future. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42395. In this article, a temperature‐ and pH‐responsive delivery system based on block‐copolymer‐capped mesoporous silica nanoparticles (MSNs) is presented. A poly[2‐(diethylamino)ethyl methacrylate)] (PDEAEMA)‐ b ‐poly( N ‐isopropyl acrylamide) (PNIPAM) shell on MSNs was obtained through the surface‐initiated atom transfer radical polymerization. The block copolymer PDEAEMA‐ b ‐PNIPAM showed both temperature‐ and pH‐responsive properties. The release of the loaded model molecules from PDEAEMA‐ b ‐PNIPAM‐coated MSNs could be controlled by changes in the temperature or pH value of the medium. The as‐desired drug‐delivery carrier may be applied to biological systems in the future. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42395. |
| Author | Yang, Mei-Yan Tan, Lei Zhuo, Ren-Xi Liu, Chuan-Jun Wu, Hai-Xia |
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In this article, a temperature‐ and pH‐responsive delivery system based on block‐copolymer‐capped mesoporous silica nanoparticles (MSNs) is presented.... In this article, a temperature‐ and pH‐responsive delivery system based on block‐copolymer‐capped mesoporous silica nanoparticles (MSNs) is presented. A... In this article, a temperature- and pH-responsive delivery system based on block-copolymer-capped mesoporous silica nanoparticles (MSNs) is presented. A... |
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| SubjectTerms | biomaterials drug-delivery systems Materials science nanoparticles nanowires and nanocrystals Polymers stimuli-sensitive polymers |
| Title | Dual-stimuli-responsive polymer-coated mesoporous silica nanoparticles used for controlled drug delivery |
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