Dual-stimuli-responsive polymer-coated mesoporous silica nanoparticles used for controlled drug delivery

ABSTRACT In this article, a temperature‐ and pH‐responsive delivery system based on block‐copolymer‐capped mesoporous silica nanoparticles (MSNs) is presented. A poly[2‐(diethylamino)ethyl methacrylate)] (PDEAEMA)‐b‐poly(N‐isopropyl acrylamide) (PNIPAM) shell on MSNs was obtained through the surface...

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Published inJournal of applied polymer science Vol. 132; no. 32
Main Authors Yang, Mei-Yan, Tan, Lei, Wu, Hai-Xia, Liu, Chuan-Jun, Zhuo, Ren-Xi
Format Journal Article
LanguageEnglish
Published Hoboken Blackwell Publishing Ltd 20.08.2015
Wiley Subscription Services, Inc
Subjects
biomaterials
drug-delivery systems
Materials science
nanoparticles
nanowires and nanocrystals
Polymers
stimuli-sensitive polymers
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Summary:ABSTRACT In this article, a temperature‐ and pH‐responsive delivery system based on block‐copolymer‐capped mesoporous silica nanoparticles (MSNs) is presented. A poly[2‐(diethylamino)ethyl methacrylate)] (PDEAEMA)‐b‐poly(N‐isopropyl acrylamide) (PNIPAM) shell on MSNs was obtained through the surface‐initiated atom transfer radical polymerization. The block copolymer PDEAEMA‐b‐PNIPAM showed both temperature‐ and pH‐responsive properties. The release of the loaded model molecules from PDEAEMA‐b‐PNIPAM‐coated MSNs could be controlled by changes in the temperature or pH value of the medium. The as‐desired drug‐delivery carrier may be applied to biological systems in the future. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42395.
Bibliography:ArticleID:APP42395
istex:FA6FBE2277896D4DF52B0441F9CCB71D334CD735
National Natural Science Foundation of China - No. 21204070
ark:/67375/WNG-ZM8TC4D2-6
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:0021-8995
1097-4628
DOI:10.1002/app.42395