Variation in innate immunity genes and risk of multiple myeloma

• Published in: Hematological oncology Vol. 29; no. 1; pp. 42 - 46
• Main Authors: Purdue, Mark P., Lan, Qing, Menashe, Idan, Zheng, Tongzhang, Zhang, Yawei, Yeager, Meredith, Hosgood III, H. Dean, Zahm, Shelia H., Chanock, Stephen J., Rothman, Nathaniel, Baris, Dalsu
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.03.2011
• Subjects: Adult; Aged; Aged, 80 and over; CC chemokine receptors; CCR7 protein; epidemiology; Female; genetics; Hepatocyte Growth Factor - genetics; Humans; Immunity; Immunity, Innate - genetics; Lymphocytes B; Lymphoma; Malignancy; Middle Aged; Multiple myeloma; Multiple Myeloma - etiology; Multiple Myeloma - genetics; Multiple Myeloma - immunology; myeloma; Plasminogen Activator Inhibitor 1 - genetics; Polymorphism, Single Nucleotide; Receptors, CCR7 - genetics; Risk Factors; Single-nucleotide polymorphism

Multiple myeloma (MM) is a B‐cell lymphoid malignancy suspected to be associated with immunologic factors. Given recent findings associating single‐nucleotide polymorphisms (SNPs) in innate immunity genes with non‐Hodgkin lymphoma, we conducted an investigation of innate immune gene variants using s...