Delivering stem cells to the healthy heart on biological sutures: effects on regional mechanical function
Current cardiac cell therapies cannot effectively target and retain cells in a specific area of the heart. Cell‐seeded biological sutures were previously developed to overcome this limitation, demonstrating targeted delivery with > 60% cell retention. In this study, both cell‐seeded and non‐seede...
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Published in | Journal of tissue engineering and regenerative medicine Vol. 11; no. 1; pp. 220 - 230 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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England
Hindawi Limited
01.01.2017
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Abstract | Current cardiac cell therapies cannot effectively target and retain cells in a specific area of the heart. Cell‐seeded biological sutures were previously developed to overcome this limitation, demonstrating targeted delivery with > 60% cell retention. In this study, both cell‐seeded and non‐seeded fibrin‐based biological sutures were implanted into normal functioning rat hearts to determine the effects on mechanical function and fibrotic response. Human mesenchymal stem cells (hMSCs) were used based on previous work and established cardioprotective effects. Non‐seeded or hMSC‐seeded sutures were implanted into healthy athymic rat hearts. Before cell seeding, hMSCs were passively loaded with quantum dot nanoparticles. One week after implantation, regional stroke work index and systolic area of contraction (SAC) were evaluated on the epicardial surface above the suture. Cell delivery and retention were confirmed by quantum dot tracking, and the fibrotic tissue area was evaluated. Non‐seeded biological sutures decreased SAC near the suture from 0.20 ± 0.01 measured in sham hearts to 0.08 ± 0.02, whereas hMSC‐seeded biological sutures dampened the decrease in SAC (0.15 ± 0.02). Non‐seeded sutures also displayed a small amount of fibrosis around the sutures (1.0 ± 0.1 mm2). Sutures seeded with hMSCs displayed a significant reduction in fibrosis (0.5 ± 0.1 mm2, p < 0.001), with quantum dot‐labelled hMSCs found along the suture track. These results show that the addition of hMSCs attenuates the fibrotic response observed with non‐seeded sutures, leading to improved regional mechanics of the implantation region. Copyright © 2014 John Wiley & Sons, Ltd. |
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AbstractList | Current cardiac cell therapies cannot effectively target and retain cells in a specific area of the heart. Cell‐seeded biological sutures were previously developed to overcome this limitation, demonstrating targeted delivery with > 60% cell retention. In this study, both cell‐seeded and non‐seeded fibrin‐based biological sutures were implanted into normal functioning rat hearts to determine the effects on mechanical function and fibrotic response. Human mesenchymal stem cells (hMSCs) were used based on previous work and established cardioprotective effects. Non‐seeded or hMSC‐seeded sutures were implanted into healthy athymic rat hearts. Before cell seeding, hMSCs were passively loaded with quantum dot nanoparticles. One week after implantation, regional stroke work index and systolic area of contraction (SAC) were evaluated on the epicardial surface above the suture. Cell delivery and retention were confirmed by quantum dot tracking, and the fibrotic tissue area was evaluated. Non‐seeded biological sutures decreased SAC near the suture from 0.20 ± 0.01 measured in sham hearts to 0.08 ± 0.02, whereas hMSC‐seeded biological sutures dampened the decrease in SAC (0.15 ± 0.02). Non‐seeded sutures also displayed a small amount of fibrosis around the sutures (1.0 ± 0.1 mm2). Sutures seeded with hMSCs displayed a significant reduction in fibrosis (0.5 ± 0.1 mm2, p < 0.001), with quantum dot‐labelled hMSCs found along the suture track. These results show that the addition of hMSCs attenuates the fibrotic response observed with non‐seeded sutures, leading to improved regional mechanics of the implantation region. Copyright © 2014 John Wiley & Sons, Ltd. Current cardiac cell therapies cannot effectively target and retain cells in a specific area of the heart. Cell-seeded biological sutures were previously developed to overcome this limitation, demonstrating targeted delivery with > 60% cell retention. In this study, both cell-seeded and non-seeded fibrin-based biological sutures were implanted into normal functioning rat hearts to determine the effects on mechanical function and fibrotic response. Human mesenchymal stem cells (hMSCs) were used based on previous work and established cardioprotective effects. Non-seeded or hMSC-seeded sutures were implanted into healthy athymic rat hearts. Before cell seeding, hMSCs were passively loaded with quantum dot nanoparticles. One week after implantation, regional stroke work index and systolic area of contraction (SAC) were evaluated on the epicardial surface above the suture. Cell delivery and retention were confirmed by quantum dot tracking, and the fibrotic tissue area was evaluated. Non-seeded biological sutures decreased SAC near the suture from 0.20 plus or minus 0.01 measured in sham hearts to 0.08 plus or minus 0.02, whereas hMSC-seeded biological sutures dampened the decrease in SAC (0.15 plus or minus 0.02). Non-seeded sutures also displayed a small amount of fibrosis around the sutures (1.0 plus or minus 0.1 mm super(2)). Sutures seeded with hMSCs displayed a significant reduction in fibrosis (0.5 plus or minus 0.1 mm super(2), p < 0.001), with quantum dot-labelled hMSCs found along the suture track. These results show that the addition of hMSCs attenuates the fibrotic response observed with non-seeded sutures, leading to improved regional mechanics of the implantation region. Current cardiac cell therapies cannot effectively target and retain cells in a specific area of the heart. Cell-seeded biological sutures were previously developed to overcome this limitation, demonstrating targeted delivery with > 60% cell retention. In this study, both cell-seeded and non-seeded fibrin-based biological sutures were implanted into normal functioning rat hearts to determine the effects on mechanical function and fibrotic response. Human mesenchymal stem cells (hMSCs) were used based on previous work and established cardioprotective effects. Non-seeded or hMSC-seeded sutures were implanted into healthy athymic rat hearts. Before cell seeding, hMSCs were passively loaded with quantum dot nanoparticles. One week after implantation, regional stroke work index and systolic area of contraction (SAC) were evaluated on the epicardial surface above the suture. Cell delivery and retention were confirmed by quantum dot tracking, and the fibrotic tissue area was evaluated. Non-seeded biological sutures decreased SAC near the suture from 0.20 ± 0.01 measured in sham hearts to 0.08 ± 0.02, whereas hMSC-seeded biological sutures dampened the decrease in SAC (0.15 ± 0.02). Non-seeded sutures also displayed a small amount of fibrosis around the sutures (1.0 ± 0.1 mm ). Sutures seeded with hMSCs displayed a significant reduction in fibrosis (0.5 ± 0.1 mm , p < 0.001), with quantum dot-labelled hMSCs found along the suture track. These results show that the addition of hMSCs attenuates the fibrotic response observed with non-seeded sutures, leading to improved regional mechanics of the implantation region. Copyright © 2014 John Wiley & Sons, Ltd. Current cardiac cell therapies cannot effectively target and retain cells in a specific area of the heart. We previously developed cell-seeded biological sutures to overcome this limitation, demonstrating targeted delivery with > 60% cell retention. Herein, we implanted both cell-seeded and non-seeded fibrin based biological sutures into normal functioning rat hearts to determine the effects on mechanical function and fibrotic response. Human mesenchymal stem cells (hMSCs) were used based on our previous work and established cardioprotective effects. Non-seeded or hMSC-seeded sutures were implanted into healthy athymic rat hearts. Prior to cell seeding, hMSCs were passively loaded with quantum dot (QD) nanoparticles. One week after implantation, regional stroke work index and systolic area of contraction (SAC) were evaluated on the epicardial surface above the suture. Cell delivery and retention were confirmed by QD tracking, and the fibrotic tissue area was evaluated. Non-seeded biological sutures decreased SAC near the suture from 0.20±0.01 measured in sham hearts to 0.08 ± 0.02, whereas hMSC-seeded biological sutures dampened the decrease in SAC (0.15 ± 0.02). Non-seeded sutures also displayed a small amount of fibrosis around the sutures (1.0 ± 0.1 mm 2 ). Sutures seeded with hMSCs displayed a significant reduction in fibrosis (0.5 ± 0.1 mm 2 , p<0.001), with QD-labeled hMSCs found along the suture track. These results show that the addition of hMSCs attenuates the fibrotic response observed with non-seeded sutures, leading to improved regional mechanics of the implantation region. |
Author | Hansen, Katrina J. Tao, Ze‐Wei Burford, Evans Guyette, Jacques P. Favreau, John T. Lessard, Jeffrey Pins, George D. Gaudette, Glenn R. |
Author_xml | – sequence: 1 givenname: Ze‐Wei surname: Tao fullname: Tao, Ze‐Wei organization: Worcester Polytechnic Institute – sequence: 2 givenname: John T. surname: Favreau fullname: Favreau, John T. organization: Worcester Polytechnic Institute – sequence: 3 givenname: Jacques P. surname: Guyette fullname: Guyette, Jacques P. organization: Worcester Polytechnic Institute – sequence: 4 givenname: Katrina J. surname: Hansen fullname: Hansen, Katrina J. organization: Worcester Polytechnic Institute – sequence: 5 givenname: Jeffrey surname: Lessard fullname: Lessard, Jeffrey organization: Worcester Polytechnic Institute – sequence: 6 givenname: Evans surname: Burford fullname: Burford, Evans organization: Worcester Polytechnic Institute – sequence: 7 givenname: George D. surname: Pins fullname: Pins, George D. organization: Worcester Polytechnic Institute – sequence: 8 givenname: Glenn R. surname: Gaudette fullname: Gaudette, Glenn R. email: gaudette@wpi.edu organization: Worcester Polytechnic Institute |
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CitedBy_id | crossref_primary_10_1007_s13726_021_00916_x crossref_primary_10_1016_j_pmatsci_2024_101249 crossref_primary_10_3389_fcvm_2018_00052 crossref_primary_10_1038_s41467_021_24921_z crossref_primary_10_1021_acsbiomaterials_6b00547 crossref_primary_10_1002_jbm_a_35683 crossref_primary_10_1002_jbm_a_36658 crossref_primary_10_1002_term_2129 crossref_primary_10_1186_s12951_019_0470_6 crossref_primary_10_1002_jbm_b_35086 crossref_primary_10_1089_biores_2016_0026 |
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Keywords | stem cells tissue regeneration wound healing cardiac biomechanics biological sutures mechanical function |
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References_xml | – volume: 44 start-page: 654 year: 2004b end-page: 660 article-title: Injectable fibrin scaffold improves cell transplant survival, reduces infarct expansion, and induces neovasculature formation in ischemic myocardium publication-title: J Am Coll Cardiol – volume: 13 start-page: 4385 year: 2009 end-page: 4402 article-title: Mesenchymal stem cell‐based therapy: a new paradigm in regenerative medicine publication-title: J Cell Molec Med – volume: 82 start-page: 104 year: 2007 end-page: 112 article-title: Discrete crosslinked fibrin microthread scaffolds for tissue regeneration publication-title: J Biomed Mater Res A – volume: 55 start-page: 240 year: 2008 end-page: 248 article-title: High‐frame rate, full‐view myocardial elastography with automated contour tracking in murine left ventricles publication-title: IEEE TUFFC – volume: 11 start-page: 238 year: 2010 end-page: 248 article-title: Growth factors induce the improved cardiac remodeling in autologous mesenchymal stem cell‐implanted failing rat hearts publication-title: J Zhejiang Univ Sci B – volume: 117 start-page: 1176 year: 2011 end-page: 1183 article-title: Mesenchymal stem cells express serine protease inhibitor to evade the host immune response publication-title: Blood – volume: 108 start-page: 863 year: 2003 end-page: 868 article-title: Systemic delivery of bone marrow‐derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution publication-title: Circulation – volume: 44 start-page: 742 year: 2006 end-page: 748 article-title: Therapeutic effect of transplanting hgf‐treated bone marrow mesenchymal cells into ccl4‐injured rats publication-title: J Hepatol – volume: 101A start-page: 809 year: 2012 end-page: 818 article-title: A novel suture‐based method for efficient transplantation of stem cells publication-title: J Biomed Mater Res A – volume: 5 start-page: 173ra25 year: 2013 article-title: Safety and efficacy of an injectable extracellular matrix hydrogel for treating myocardial infarction publication-title: Sci Transl Med – volume: 112 start-page: 1128 year: 2005 end-page: 1135 article-title: Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy publication-title: Circulation – volume: 364 start-page: 141 year: 2004 end-page: 148 article-title: Intracoronary autologous bone‐marrow cell transfer after myocardial infarction: the boost randomised controlled clinical trial publication-title: Lancet – volume: 14 start-page: 1025 year: 2008 end-page: 1036 article-title: Enhancing efficacy of stem cell transplantation to the heart with a pegylated fibrin biomatrix publication-title: Tissue Eng A – volume: 297 start-page: H257 year: 2009 end-page: H267 article-title: Clinical assessment of left ventricular rotation and strain: a novel approach for quantification of function in infarcted myocardium and its border zones publication-title: Am J Physiol – volume: 32 start-page: 5558 year: 2011 end-page: 5567 article-title: Enhancement of cell retention and functional benefits in myocardial infarction using human amniotic‐fluid stem‐cell bodies enriched with endogenous ecm publication-title: Biomaterials – volume: 18 start-page: 321 year: 2009 end-page: 9 article-title: Dose‐dependent effects of intravenous allogeneic mesenchymal stem cells in the infarcted porcine heart publication-title: Stem Cell Devel – volume: 53 start-page: 2262 year: 2009 end-page: 2269 article-title: The balance study: clinical benefit and long‐term outcome after intracoronary autologous bone marrow cell transplantation in patients with acute myocardial infarction publication-title: J Am Coll Cardiol – volume: 10 start-page: 403 year: 2004a end-page: 409 article-title: Fibrin glue alone and skeletal myoblasts in a fibrin scaffold preserve cardiac function after myocardial infarction publication-title: Tissue Eng – volume: 112 start-page: I150 year: 2005 end-page: I156 article-title: Radiolabeled cell distribution after intramyocardial, intracoronary, and interstitial retrograde coronary venous delivery: implications for current clinical trials publication-title: Circulation – volume: 25 start-page: 720 year: 2005 end-page: 724 article-title: Randomized, multicenter trial of conventional ventilation versus high‐frequency oscillatory ventilation for the early management of respiratory failure in term or near‐term infants in colombia publication-title: J Perinatol – volume: 11 start-page: 14 year: 2009 end-page: 19 article-title: Novel thermosensitive hydrogel injection inhibits post‐infarct ventricle remodelling publication-title: Eur J Heart Fail – volume: 96 start-page: 301 year: 2011 end-page: 312 article-title: Fibrin microthreads support mesenchymal stem cell growth while maintaining differentiation potential publication-title: J Biomed Mater Res A – volume: 47 start-page: 1672 year: 2006 end-page: 1682 article-title: Grading of myocardial dysfunction by tissue doppler echocardiography: a comparison between velocity, displacement, and strain imaging in acute ischemia publication-title: J Am Coll Cardiol – volume: 102 start-page: 11474 year: 2005 end-page: 11479 article-title: Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction publication-title: Proc Natl Acad Sci U S A – volume: 100 start-page: 8407 year: 2003 end-page: 8411 article-title: Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects publication-title: Proc Natl Acad Sci U S A – volume: 25 start-page: 2128 year: 2007 end-page: 2138 article-title: Finding fluorescent needles in the cardiac haystack: tracking human mesenchymal stem cells labeled with quantum dots for quantitative three‐dimensional fluorescence analysis publication-title: Stem Cells – volume: 303 start-page: H549 year: 2012 end-page: H558 article-title: Layer‐specific strain analysis: investigation of regional deformations in a rat model of acute versus chronic myocardial infarction publication-title: Am J Physiol – volume: 54 start-page: 1619 year: 2009 end-page: 1626 article-title: Noninvasive quantification and optimization of acute cell retention by in vivo positron emission tomography after intramyocardial cardiac‐derived stem cell delivery publication-title: J Am Coll Cardiol – volume: 447 start-page: 880 year: 2007 end-page: 881 article-title: Pluripotency of mesenchymal stem cells derived from adult marrow publication-title: Nature – volume: 280 start-page: H2936 year: 2001 end-page: H2943 article-title: Assessment of the time constant of relaxation: insights from simulations and hemodynamic measurements publication-title: Am J Physiol Heart Circ Physiol – volume: 70 start-page: 121 year: 2006 end-page: 129 article-title: Multipotent mesenchymal stem cells reduce interstitial fibrosis but do not delay progression of chronic kidney disease in collagen4a3‐deficient mice publication-title: Kidney Int – volume: 40 start-page: 893 year: 2007 end-page: 899 article-title: Therapeutic potential of bone marrow‐derived mesenchymal stem cells on experimental liver fibrosis publication-title: Clin Biochem – volume: 112 start-page: 214 year: 2005 end-page: 223 article-title: Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: Short‐ and long‐term effects publication-title: Circulation – year: 2008 – volume: 105 start-page: 1815 year: 2005 end-page: 1822 article-title: Human mesenchymal stem cells modulate allogeneic immune cell responses publication-title: Blood – volume: 52 start-page: 1083 year: 2012 end-page: 1090 article-title: Regional mechanics determine collagen fiber structure in healing myocardial infarcts publication-title: J Mol Cell Cardiol – volume: 106 start-page: 14022 year: 2009 end-page: 14027 article-title: Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity publication-title: Proc Natl Acad Sci U S A – volume: 936 start-page: 355 year: 2001 end-page: 367 article-title: Fibrin and wound healing publication-title: Ann N Y Acad Sci – volume: 18 start-page: 270 year: 2013 end-page: 279 article-title: Intramyocardial injection of heart tissue‐derived extracellular matrix improves postinfarction cardiac function in rats publication-title: J Cardiovasc Pharmacol Ther – volume: 5 start-page: 494 year: 2004 end-page: 498 article-title: Early association of electrocardiogram alteration with infarct size and cardiac function after myocardial infarction publication-title: J Zhejiang Univ Sci – volume: 98 start-page: 10344 year: 2001 end-page: 10349 article-title: Mobilized bone marrow cells repair the infarcted heart, improving function and survival publication-title: Proc Natl Acad Sci U S A – volume: 29 start-page: 154 year: 2007 end-page: 162 article-title: Accuracy and reproducibility of a subpixel extended phase correlation method to determine micron level displacements in the heart publication-title: Med Eng Phys – volume: 355 start-page: 1210 year: 2006 end-page: 1221 article-title: Intracoronary bone marrow‐derived progenitor cells in acute myocardial infarction publication-title: N Engl J Med |
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Snippet | Current cardiac cell therapies cannot effectively target and retain cells in a specific area of the heart. Cell‐seeded biological sutures were previously... Current cardiac cell therapies cannot effectively target and retain cells in a specific area of the heart. Cell-seeded biological sutures were previously... Current cardiac cell therapies cannot effectively target and retain cells in a specific area of the heart. We previously developed cell-seeded biological... |
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SubjectTerms | Animals biological sutures cardiac biomechanics Cell Differentiation Cell Survival Cell Transplantation Fibrin - pharmacology Fibrosis Heart - physiology Humans Male mechanical function Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stem Cells - cytology Quantum Dots Rats Rats, Nude Regenerative medicine stem cells Stress, Mechanical Sutures Tissue Engineering tissue regeneration Tissue Scaffolds wound healing |
Title | Delivering stem cells to the healthy heart on biological sutures: effects on regional mechanical function |
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