Single-Cell Transcriptomic Analysis of Kaposi Sarcoma

• Published in: PLoS pathogens Vol. 21; no. 4; p. e1012233
• Main Authors: Rauch, Daniel A., Ramos, Paula Valiño, Khanfar, Mariam, Harding, John, Joseph, Ancy, Fahad, Anam, Simonson, Paul, Risch, Isabel, Griffith, Obi, Griffith, Malachi, Ratner, Lee
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2025; Public Library of Science (PLoS)
• Subjects: Aged; Analysis; B cells; Biology and Life Sciences; Causes of; Cell populations; Development and progression; Endothelial Cells - metabolism; Endothelial Cells - pathology; Endothelial Cells - virology; Endothelium; Female; Gene Expression Profiling; Genes; Herpesvirus 8, Human - genetics; Human herpesvirus 8; Humans; Identification and classification; Ipilimumab; Kaposi's sarcoma; Male; Medicine and health sciences; Methods; Middle Aged; Physiological aspects; Research and Analysis Methods; RNA sequencing; Sarcoma, Kaposi - genetics; Sarcoma, Kaposi - metabolism; Sarcoma, Kaposi - pathology; Sarcoma, Kaposi - virology; Single-Cell Analysis - methods; Skin; Transcriptome; United States; Kansas

Kaposi Sarcoma (KS) is a complex tumor caused by KS-associated herpesvirus 8 (KSHV). Histological analysis reveals a mixture of “spindle cells”, vascular-like spaces, extravasated erythrocytes, and immune cells. In order to elucidate the infected and uninfected cell types in KS tumors, we examined t...