Molecular mechanisms for tumour resistance to chemotherapy

• Published in: Clinical and experimental pharmacology & physiology Vol. 43; no. 8; pp. 723 - 737
• Main Authors: Pan, Shu-Ting, Li, Zhi-Ling, He, Zhi-Xu, Qiu, Jia-Xuan, Zhou, Shu-Feng
• Format: Journal Article
• Language: English
• Published: Australia Blackwell Publishing Ltd 01.08.2016; Wiley Subscription Services, Inc
• Subjects: Antineoplastic Agents - administration & dosage; Antineoplastic Agents - metabolism; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - metabolism; Apoptosis; ATP Binding Cassette Transporter, Sub-Family B - genetics; ATP Binding Cassette Transporter, Sub-Family B - metabolism; ATP-Binding Cassette, Sub-Family B, Member 1 - genetics; ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism; Autophagy; Cancer; Chemotherapy; Deregulation; Drug Resistance, Neoplasm - drug effects; Drug Resistance, Neoplasm - physiology; Drugs; Humans; Inactivation; Multidrug Resistance-Associated Proteins - genetics; Multidrug Resistance-Associated Proteins - metabolism; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - metabolism; P-gp; Signal Transduction - drug effects; Signal Transduction - physiology; Tumors; tumour resistance; apoptosis; cancer; P-gp; autophagy; chemotherapy; tumour resistance

Summary Chemotherapy is one of the prevailing methods used to treat malignant tumours, but the outcome and prognosis of tumour patients are not optimistic. Cancer cells gradually generate resistance to almost all chemotherapeutic drugs via a variety of distinct mechanisms and pathways. Chemotherapeu...