Translational PET Imaging of Spinal Cord Injury with the Serotonin Transporter Tracer [11C]AFM

• Published in: Molecular imaging and biology Vol. 24; no. 4; pp. 560 - 569
• Main Authors: Fang, Hanyi, Rossano, Samantha, Wang, Xingxing, Nabulsi, Nabeel, Kelley, Brian, Fowles, Krista, Ropchan, Jim, Strittmatter, Stephen M., Carson, Richard E., Huang, Yiyun
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.08.2022; Springer Nature B.V
• Subjects: Animal models; Animals; Binding; Biomarkers; Citalopram; Humans; Imaging; Indicators and Reagents; Innervation; Locomotion; Medical imaging; Medicine; Medicine & Public Health; Neuroimaging; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Radiology; Rats; Research Article; Rodents; Serotonin; Serotonin - metabolism; Serotonin Plasma Membrane Transport Proteins - metabolism; Serotonin transporter; Spinal Cord - diagnostic imaging; Spinal cord injuries; Spinal Cord Injuries - diagnostic imaging; Spinal Cord Injuries - metabolism; Thorax; Tissue Distribution; Tomography; Translation; Serotonin transporter; [; PET imaging; Spinal cord injury; C]AFM; [11C]AFM

Purpose The descending raphespinal serotonin (5-HT) system contributes to neural activities required for locomotion. The presynaptic serotonin transporter (SERT) is a marker of 5-HT innervation. In this study, we explored the use of PET imaging with the SERT radioligand [ 11 C]AFM as a biomarker of...